DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hsl and LIPE

DIOPT Version :10

Sequence 1:NP_611463.1 Gene:Hsl / 37289 FlyBaseID:FBgn0034491 Length:881 Species:Drosophila melanogaster
Sequence 2:NP_005348.2 Gene:LIPE / 3991 HGNCID:6621 Length:1076 Species:Homo sapiens


Alignment Length:884 Identity:282/884 - (31%)
Similarity:421/884 - (47%) Gaps:162/884 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 GHEDDGPQAVNGKDTHQHVP---------ADLEATYGTLYAACQDHAAFF-ARDHTEFGQRLHAA 79
            |:....|........|:|..         .||.....:|....:|:.||| ::...|..|||...
Human   273 GYSGTSPHEKTSARNHRHYQDTASRLIHNMDLRTMTQSLVTLAEDNIAFFSSQGPGETAQRLSGV 337

  Fly    80 HIAWQDFIVLANRLVQQIDAFAHEYDFDEQTPGNGYRSFIYVTNACIAHGISICQQLTATRSTIF 144
            ....::..:.....:.::...||.:|.|.:||.|||||.::....|:||.:...:.:.:.|.:||
Human   338 FAGVREQALGLEPALGRLLGVAHLFDLDPETPANGYRSLVHTARCCLAHLLHKSRYVASNRRSIF 402

  Fly   145 FRKKFYMKEVEACSQLLSSLCTCLQY---LLILRQWSASTGDLFACGNH--TAEQLFELGDTINQ 204
            ||....:.|:||....|:.|...:.|   ||:..:    .|.||..|:.  ||:.|.|. .|:::
Human   403 FRTSHNLAELEAYLAALTQLRALVYYAQRLLVTNR----PGVLFFEGDEGLTADFLREY-VTLHK 462

  Fly   205 YCFYGRCLGFQYGDSIRGVLRFLGISMASYSESYYSQEGDGPIVKTTRSLWTSGKYLMNPELRAR 269
            .||||||||||:..:||..|:.:.|.:.|:.|.|...|....:..:  ||:|||::.::||||..
Human   463 GCFYGRCLGFQFTPAIRPFLQTISIGLVSFGEHYKRNETGLSVAAS--SLFTSGRFAIDPELRGA 525

  Fly   270 RIVNISQNAKIDFCKSFWFLAESEMMHKLPSIVGSSIKVNRLIELPAEPLKLPRRKNFKASDNLS 334
            ....|:||..:.|.|:||.:.|.|::..|.::..::::|:||:.||.|..::|          |:
Human   526 EFERITQNLDVHFWKAFWNITEMEVLSSLANMASATVRVSRLLSLPPEAFEMP----------LT 580

  Fly   335 SDVNQNQGDGDFVEIPVPTAHLGPGLPVSVRLLSARRRSGM-----------LGEGRYRGWHKP- 387
            :|....      |.|..|.||.||| ||.|||:|...|.|.           .|:.....|.:| 
Human   581 ADPTLT------VTISPPLAHTGPG-PVLVRLISYDLREGQDSEELSSLIKSNGQRSLELWPRPQ 638

  Fly   388 -IPPSPSILFHCHGGGFVAQSSKSHELYLRDWAVALDCPILSVDYSLAPEAPFPRALQEVYYAYC 451
             .|.|.|::.|.||||||||:|:|||.||:.||..|..||:|:||||||||||||||:|.::|||
Human   639 QAPRSRSLIVHFHGGGFVAQTSRSHEPYLKSWAQELGAPIISIDYSLAPEAPFPRALEECFFAYC 703

  Fly   452 WLLNNTELLGTTAERVVCAGDSAGANLSIGVALKCIEQGVRVPDGLFLAYCPTLVSFVPSPARLL 516
            |.:.:..|||:|.||:..||||||.||...|||:....|||||||:..||..|::....||:|||
Human   704 WAIKHCALLGSTGERICLAGDSAGGNLCFTVALRAAAYGVRVPDGIMAAYPATMLQPAASPSRLL 768

  Fly   517 CLMDPLLPFGFMMRCLRAYAAPAQETLQQNAKQVEDAAQIRNVPKSNVGSLNSSRRTSMARSPLS 581
            .|||||||...:.:|:.|||          ..:.||.:   |..:..:|.:...||.:       
Human   769 SLMDPLLPLSVLSKCVSAYA----------GAKTEDHS---NSDQKALGMMGLVRRDT------- 813

  Fly   582 PLEASMNPDDESSDTFASASASYHSQTVERTDLPHTEGDNSSCVSFEDDSQPIVHYPIEISADPP 646
               |.:..|      |...::|:.:..:|      ..|..|     :..|:||        |:|.
Human   814 ---ALLLRD------FRLGASSWLNSFLE------LSGRKS-----QKMSEPI--------AEPM 850

  Fly   647 KDTASAAYIDNFLDKYLIDTATMEVTEETAPEAVQAQANGHAKISSDDDILVETGRDLVAIDTLQ 711
            :.:.|                          ||..||..|..   ..|.:...|.|||    :|:
Human   851 RRSVS--------------------------EAALAQPQGPL---GTDSLKNLTLRDL----SLR 882

  Fly   712 GRLQEA-----VNNITNTLTRCTQS-------YEIHGSNVMAQQDVRNMD---ALIARSP----- 756
            |..:.:     ::....||:..|.|       .|..|....|:.::..||   .:.|..|     
Human   883 GNSETSSDTPEMSLSAETLSPSTPSDVNFLLPPEDAGEEAEAKNELSPMDRGLGVRAAFPEGFHP 947

  Fly   757 --SEEFAFDVP-------KDPFLSPYWASDEWLSQLPETKILTLNMDPCLDDCVMFAKKLKRLGR 812
              |.:.|..:|       |:||:||..|.|..|..||...|:...:||.|||.||.|::|:.||:
Human   948 RRSSQGATQMPLYSSPIVKNPFMSPLLAPDSMLKSLPPVHIVACALDPMLDDSVMLARRLRNLGQ 1012

  Fly   813 QVDLEILEGLPHGFLNFTMLSNEAMEGSKKCIKSLQTLL 851
            .|.|.::|.||||||....|..|..:.::.|::.::.:|
Human  1013 PVTLRVVEDLPHGFLTLAALCRETRQAAELCVERIRLVL 1051

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HslNP_611463.1 HSL_N 51..376 CDD:461882 107/341 (31%)
alpha/beta hydrolases 395..>539 CDD:473884 83/143 (58%)
Aes <767..838 CDD:440422 32/70 (46%)
LIPENP_005348.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..198
PRK10263 <4..>115 CDD:236669
tolA 48..>276 CDD:236545 1/2 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 229..250
HSL_N 307..615 CDD:461882 107/331 (32%)
alpha/beta hydrolases 647..>795 CDD:473884 84/157 (54%)
Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole. /evidence=ECO:0000250|UniProtKB:Q5NUF3 651..653 1/1 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 838..930 26/137 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1055..1076
Blue background indicates that the domain is not in the aligned region.

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