Protein Alignment Hsl and Aadacl4fm1

DIOPT Version :10

• Sequence 1: NP_611463.1
• Gene: Hsl / 37289
• FlyBaseID: FBgn0034491
• Length: 881
• Species: Drosophila melanogaster
• Sequence 2: NP_941064.2
• Gene: Aadacl4fm1 / 381572
• MGIID: 2685880
• Length: 407
• Species: Mus musculus
• Alignment Length: 508
• Identity: 96/508 - (18%)
• Similarity: 143/508 - (28%)
• Gaps: 219/508 - (43%)

  Fly   331 DNLSSDVNQNQG----DGDFVEIPVPTAHLGPGLPVSVRLLSARRRSGMLGEGRYRGWHKPIPPS 391
            |:|||  .:|.|    |..|..||             |||...:..|.              .|.
Mouse    77 DSLSS--KENHGVFVKDLRFGTIP-------------VRLFRPKAASS--------------KPR 112

  Fly   392 PSILFHCHGGGFVAQSSKSHELYLRDWAVALDCPILSVDYSLAPEAPFPRALQEVYYAYCWLLNN 456
            ..|||. ||||.:..|..||.......|...|..::||.|...|....|....:...|....|.:
Mouse   113 RGILFF-HGGGAMIGSLDSHHNLCTFLARETDSVLVSVGYRKLPYYHHPSLYHDCINASIHFLKS 176

  Fly   457 TELLGTTAERVVCAGDSAGANLSIGVALKCIEQGVRVPD--GLFLAYCPTLVSF-VPSPARLLCL 518
            .:..|....|||..|:|.|...:: |..:.:.....:|.  ...|.| |.|.:| ..||:.|:..
Mouse   177 LKAYGIDPSRVVICGESIGGAAAV-VVTQTLLSRTDIPKIRAQVLIY-PILQAFYFQSPSHLMHK 239

  Fly   519 MDPLLPFGFMMRCLRAYAAPAQETLQQNAKQVEDAAQIRNVPKSNVGSLNSSRRTSMARSP-LSP 582
            ..|.|...||:.|:..|.|                             ::.|.:.:|.... :||
Mouse   240 NIPFLTKDFMITCICKYLA-----------------------------IDFSWKDAMLTGACISP 275

  Fly   583 -----LEASMNPDDESSDTFASASASYHSQTVERTDLPHTEGDNSSCVSFEDDSQPIVHYPIEIS 642
                 .|..::||                      ::|.         .|....||
Mouse   276 SAWKKYEKWLSPD----------------------NIPK---------RFRTTYQP--------- 300

  Fly   643 ADPPKDTASAAYIDNFLDKYLIDTATMEVTEETAPEAVQAQANGHAKISSDDDILVETGRDLVAI 707
            .:.|.....|||::                            ..||
Mouse   301 PESPAPFNEAAYLE----------------------------TKHA------------------- 318

  Fly   708 DTLQGRLQEAVNNITNTLTRCTQSYEIHGSNVMAQQDVRNMDALIARSPSEEFAFDVPKDPFLSP 772
                                                  .|:|                    :||
Mouse   319 --------------------------------------MNID--------------------ISP 325

  Fly   773 YWASDEWLSQLPETKILTLNMDPCLDDCVMFAKKLKRLGRQVDLEILEGLPHG 825
            ..|.|:.::||||..:::|:.|...||.:::.|:|:..|..|....:|...||
Mouse   326 LVADDKIIAQLPEAFLVSLHWDIIRDDVLLYKKRLEDQGVPVTWHHVEDGFHG 378

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsl	NP_611463.1	HSL_N	51..376	CDD:461882	14/48 (29%)
		alpha/beta hydrolases	395..>539	CDD:473884	42/146 (29%)
		Aes	<767..838	CDD:440422	19/59 (32%)
Aadacl4fm1	NP_941064.2	alpha/beta hydrolases	115..380	CDD:473884	81/441 (18%)
		Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole. /evidence=ECO:0000250|UniProtKB:Q5NUF3	119..121		1/1 (100%)