Protein Alignment Hsl and AADACL2

DIOPT Version :9

• Sequence 1: NP_611463.1
• Gene: Hsl / 37289
• FlyBaseID: FBgn0034491
• Length: 881
• Species: Drosophila melanogaster
• Sequence 2: NP_997248.2
• Gene: AADACL2 / 344752
• HGNCID: 24427
• Length: 401
• Species: Homo sapiens
• Alignment Length: 502
• Identity: 103/502 - (20%)
• Similarity: 158/502 - (31%)
• Gaps: 223/502 - (44%)

  Fly   343 DGDFVEIPVPTAHLGPGLPVSVRLLSARRRSGMLGEGRYRGWHKPIPPSPSILFHCHGGGFVAQS 407
            |..||:||             |||...:|:|    |.|.|.           :.:.|||||...|
Human    83 DTTFVDIP-------------VRLYLPKRKS----ETRRRA-----------VIYFHGGGFCFGS 119

  Fly   408 SKSHEL-YLRDW-AVALDCPILSVDYSLAPEAPFPRALQEVYYAYCWLLNNTEL--LGTTAERVV 468
            ||.... :|..| |..||..::.|||.|||:..||...::...|..:.|....|  .|....|:.
Human   120 SKQRAFDFLNRWTANTLDAVVVGVDYRLAPQHHFPAQFEDGLAAVKFFLLEKILTKYGVDPTRIC 184

  Fly   469 CAGDSAGANLSIGVALKCIEQGVRVPDGLFLAYCPTLVSFVPSPARLLCLMDPLLPFGFMMRCLR 533
            .||||:|.||:..|
Human   185 IAGDSSGGNLATAV--------------------------------------------------- 198

  Fly   534 AYAAPAQETLQQNAKQVEDAAQIRNVPKSNVGSLNSSRRTSMARSPLSPLEASMNPDDESSDTFA 598
                         .:||::.|:|::..|                     ::..:.|..:.:|::
Human   199 -------------TQQVQNDAEIKHKIK---------------------MQVLLYPGLQITDSY- 228

  Fly   599 SASASYHSQTVERTDLP-HTEGDNSSCVSFEDDSQPIVHYPIEISADPPKDTASAAYIDNFLDKY 662
                           || |.|.::...::                    :|.|
Human   229 ---------------LPSHRENEHGIVLT--------------------RDVA------------ 246

  Fly   663 LIDTATMEVT-EETAPEAVQAQANGHAKISS-------DDDILV--ETGRDLVAIDTLQGRLQEA 717
             |...::..| :|..|.|:  :.|.|..:.|       :..||:  :..:|.|..:.:.|.|
Human   247 -IKLVSLYFTKDEALPWAM--RRNQHMPLESRHLFKFVNWSILLPEKYRKDYVYTEPILGGL--- 305

  Fly   718 VNNITNTLTRCTQSYEIHGSNVMAQQDVRNMDALIARSPSEEFAFDVPKDPFLSPYWASDEWLSQ 782
                         ||.:.|..     |.|.:                       |..|:|..|..
Human   306 -------------SYSLPGLT-----DSRAL-----------------------PLLANDSQLQN 329

  Fly   783 LPETKILTLNMDPCLDDCVMFAKKLKRLGRQVDLEILEGLPHGFLNF 829
            ||.|.|||...|...||.:|:..:|:.:|.||..|.:|...||.|:|
Human   330 LPLTYILTCQHDLLRDDGLMYVTRLRNVGVQVVHEHIEDGIHGALSF 376

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsl	NP_611463.1	HSL_N	51..376	CDD:283906	10/32 (31%)
		Aes	350..>537	CDD:223730	43/190 (23%)
		Abhydrolase	395..>539	CDD:304388	34/147 (23%)
		Abhydrolase	<767..827	CDD:304388	22/59 (37%)
AADACL2	NP_997248.2	Aes	77..372	CDD:223730	99/496 (20%)
		Abhydrolase_3	107..372	CDD:285143	86/444 (19%)
		Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole. /evidence=ECO:0000250|UniProtKB:Q5NUF3	111..113		1/1 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0657
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263520at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820