DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsl and AADACL4

DIOPT Version :9

Sequence 1:	NP_611463.1	Gene:	Hsl / 37289	FlyBaseID:	FBgn0034491	Length:	881	Species:	Drosophila melanogaster
Sequence 2:	NP_001013652.1	Gene:	AADACL4 / 343066	HGNCID:	32038	Length:	407	Species:	Homo sapiens

Alignment Length:	188	Identity:	46/188 - (24%)
Similarity:	65/188 - (34%)	Gaps:	38/188 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   362 VSVRLLSARRRSGMLGEGRYRGWHKPIPPSPSILFHCHGGGFVAQSSKSHELYLRDWAVALDCPI 426
            :.|||...:..|..              |...|:|: |||..|..|...:.......|...:..:
Human    97 IPVRLFQPKAASSR--------------PRRGIIFY-HGGATVFGSLDCYHGLCNYLARETESVL 146

  Fly   427 LSVDYSLAPEAPFPRALQEVYYAYCWLLNNTELLGTTAERVVCAGDSAGANLSIGVALKCIEQGV 491
            |.:.|...|:...|...|:...|....|...|..|....|||..|:|.|     |.|:..|.|.:
Human   147 LMIGYRKLPDHHSPALFQDCMNASIHFLKALETYGVDPSRVVVCGESVG-----GAAVAAITQAL 206

  Fly   492 -------RVPDGLFL-----AYCPTLVSFVPSPARLLCLMDPLLPFGFMMRCLRAYAA 537
                   |:...:.:     |:|..|.||..:.      ..|||...||:..|..|.|
Human   207 VGRSDLPRIRAQVLIYPVVQAFCLQLPSFQQNQ------NVPLLSRKFMVTSLCNYLA 258

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsl	NP_611463.1	HSL_N	51..376	CDD:283906	4/13 (31%)
		Aes	350..>537	CDD:223730	45/186 (24%)
		Abhydrolase	395..>539	CDD:304388	40/155 (26%)
		Abhydrolase	<767..827	CDD:304388
AADACL4	NP_001013652.1	Aes	85..378	CDD:223730	46/188 (24%)
		Abhydrolase	115..378	CDD:304388	41/156 (26%)
		Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole. /evidence=ECO:0000250\|UniProtKB:Q5NUF3	119..121		1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0657
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263520at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820