Protein Alignment Hsl and Nceh1

DIOPT Version :9

• Sequence 1: NP_611463.1
• Gene: Hsl / 37289
• FlyBaseID: FBgn0034491
• Length: 881
• Species: Drosophila melanogaster
• Sequence 2: NP_001120996.1
• Gene: Nceh1 / 294930
• RGDID: 1311104
• Length: 408
• Species: Rattus norvegicus
• Alignment Length: 553
• Identity: 109/553 - (19%)
• Similarity: 164/553 - (29%)
• Gaps: 229/553 - (41%)

  Fly   292 SEMMHKLPSIVGSSIKVNRLIELPAEPLKLPRRKNF------KASDNLSSDVNQNQGDGDFVEIP 350
            |.::|.|    |.|   :.||.|           ||      |.|...|..|.....|.|.||:.
  Rat    47 SNLIHSL----GLS---HHLITL-----------NFIIISFGKKSARSSPRVKVTDTDFDGVEVR 93

  Fly   351 VPTAHLGPGLPVSVRLLSARRRSGMLGEGRYRGWHKPIPPSPSILFHCHGGGFVAQSSK--SHEL 413
            |                             :.|..||..|....:.:.||||:...|:|  .::.
  Rat    94 V-----------------------------FEGPPKPDEPLRRSVVYIHGGGWALASAKISYYDQ 129

  Fly   414 YLRDWAVALDCPILSVDYSLAPEAPFPRALQEVYYAYCWLLNNTELLG---TTAERVVCAGDSAG 475
            .....|..|:..|:|::|.|.|:..||..:.:|..|..:.| ..|:|.   ....||..:|||||
  Rat   130 LCTAMAEELNAVIVSIEYRLVPQVYFPEQIHDVIRATKYFL-QPEVLDKYKVDPGRVGVSGDSAG 193

  Fly   476 ANLSIGVALKCIEQGVRVPDGLFLAYCPTLVSFVPSPARLLCLMDPLLPFGFMMRCLRAYAAPAQ 540
            .||:..:..:.                 |.|..:.:..:|..|:.|:|
  Rat   194 GNLAAALGQQF-----------------TYVESLKNKLKLQALIYPVL----------------- 224

  Fly   541 ETLQQNAKQVEDAAQIRNVPKSNVGSLNSSRRTSMARSPLSPLEASMNPDDESSDTFASASASYH 605
                    |..|.    |.|.                     .:.|||
  Rat   225 --------QALDF----NTPS---------------------YQQSMN----------------- 239

  Fly   606 SQTVERTDLPHTEGDNSSCVSFEDDSQPIVHYPIEISADPPKDTASAAYIDNFLDKYLIDTATME 670
                                      .||:          |:......::|.|...|
  Rat   240 --------------------------TPIL----------PRHVMVRYWVDYFKGNY-------- 260

  Fly   671 VTEETAPEAVQAQ-ANGHAKISSDDDILVETGRDLVAIDTLQGRLQEAVNNITNTLTRCTQSYEI 734
                   :.|:|. .|.|            |..|:.....|:.||.
  Rat   261 -------DFVEAMIVNNH------------TSLDVERAAALRARLD------------------- 287

  Fly   735 HGSNVMAQQDVRNMDALIARSPSEEFAFDVPK--DPFLSPYWASDEWLSQLPETKILTLNMDPCL 797
             .::::.....:|...::..........::|:  |...||..|..|.|..||:|.|||...|...
  Rat   288 -WTSLLPSSIKKNYKPVLQTIGDARIVKEIPQLLDAAASPLIAEQEVLQALPKTYILTCEHDVLR 351

  Fly   798 DDCVMFAKKLKRLGRQVDLEILEGLPHGFLNFT 830
            ||.:|:||:|:..|..|.|:..|...||.:.||
  Rat   352 DDGIMYAKRLESAGVNVTLDHFEDGFHGCMIFT 384

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsl	NP_611463.1	HSL_N	51..376	CDD:283906	19/89 (21%)
		Aes	350..>537	CDD:223730	40/191 (21%)
		Abhydrolase	395..>539	CDD:304388	35/148 (24%)
		Abhydrolase	<767..827	CDD:304388	25/59 (42%)
Nceh1	NP_001120996.1	Aes	70..385	CDD:223730	99/512 (19%)
		Abhydrolase_3	109..382	CDD:285143	84/440 (19%)
		Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole. /evidence=ECO:0000250|UniProtKB:Q5NUF3	113..115		1/1 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0657
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263520at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820