DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Hsl and Lipe

DIOPT Version :10

Sequence 1:NP_611463.1 Gene:Hsl / 37289 FlyBaseID:FBgn0034491 Length:881 Species:Drosophila melanogaster
Sequence 2:NP_036991.1 Gene:Lipe / 25330 RGDID:3010 Length:1068 Species:Rattus norvegicus


Alignment Length:877 Identity:286/877 - (32%)
Similarity:421/877 - (48%) Gaps:139/877 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 KLGHEDDGPQAVNGKDTHQHVPA-------DLEATYGTLYAACQDHAAFF-ARDHTEFGQRLHAA 79
            ||.|   |.:.:..|..|....|       ||.....:|.|..:|:.||| ::...|..:||...
  Rat   275 KLPH---GKKGILQKHKHYWDTASAFSHSMDLRTMTQSLVALAEDNMAFFSSQGPGETARRLSNV 336

  Fly    80 HIAWQDFIVLANRLVQQIDAFAHEYDFDEQTPGNGYRSFIYVTNACIAHGISICQQLTATRSTIF 144
            ....::..:.....:.|:...||.:|.|.:||.|||||.::....|:||.:...:.:.:.|.:||
  Rat   337 FAGVREQALGLEPTLGQLLGVAHHFDLDTETPANGYRSLVHTARCCLAHLLHKSRYVASNRRSIF 401

  Fly   145 FRKKFYMKEVEACSQLLSSLCTCLQY---LLILRQWSASTGDLFACGNHTAEQLFELGD--TINQ 204
            ||....:.|:||....|:.|.....|   ||.:.:    .|.||..|:......| |.|  |:::
  Rat   402 FRASHNLAELEAYLAALTQLRALAYYAQRLLTINR----PGVLFFEGDEGLSADF-LQDYVTLHK 461

  Fly   205 YCFYGRCLGFQYGDSIRGVLRFLGISMASYSESYYSQEGDGPIVKTTRSLWTSGKYLMNPELRAR 269
            .||||||||||:..:||..|:.|.|.:.|:.|.|  :..:..:..|..||:|.|::.::||||..
  Rat   462 GCFYGRCLGFQFTPAIRPFLQTLSIGLVSFGEHY--KRNETGLSVTASSLFTGGRFAIDPELRGA 524

  Fly   270 RIVNISQNAKIDFCKSFWFLAESEMMHKLPSIVGSSIKVNRLIELPAEPLKLPRRKNFKASDNLS 334
            ....|.||..:.|.|:||.:.|.|::..|.::..::::|:||:.||.|..::|          |:
  Rat   525 EFERIIQNLDVHFWKAFWNITEIEVLSSLANMASTTVRVSRLLSLPPEAFEMP----------LT 579

  Fly   335 SDVNQNQGDGDFVEIPVPTAHLGPGLPVSVRLLSARRRSG----ML-----GEG---RYRGWHKP 387
            ||....      |.|..|.||.||| ||..||:|...|.|    ||     .||   ..|...:.
  Rat   580 SDPKLT------VTISPPLAHTGPG-PVLARLISYDLREGQDSKMLNSLAKSEGPRLELRPRPQQ 637

  Fly   388 IPPSPSILFHCHGGGFVAQSSKSHELYLRDWAVALDCPILSVDYSLAPEAPFPRALQEVYYAYCW 452
            .|.|.:::.|.||||||||:|||||.||::||..|..||:|:||||||||||||||:|.::||||
  Rat   638 APRSRALVVHIHGGGFVAQTSKSHEPYLKNWAQELGVPIISIDYSLAPEAPFPRALEECFFAYCW 702

  Fly   453 LLNNTELLGTTAERVVCAGDSAGANLSIGVALKCIEQGVRVPDGLFLAYCPTLVSFVPSPARLLC 517
            .:.:.||||:|.||:..||||||.||.|.|:|:....|||||||:..||..|.:....||:|||.
  Rat   703 AVKHCELLGSTGERICLAGDSAGGNLCITVSLRAAAYGVRVPDGIMAAYPVTTLQSSASPSRLLS 767

  Fly   518 LMDPLLPFGFMMRCLRAYAAPAQE---TLQQNAKQVEDAAQ------IRNVPKSNVGSLNSSRRT 573
            |||||||...:.:|:.||:....|   ...|.|..|....|      :|::.......|||....
  Rat   768 LMDPLLPLSVLSKCVSAYSGTETEDHFDSDQKALGVMGLVQRDTSLFLRDLRLGASSWLNSFLEL 832

  Fly   574 SMARSPLSPLEA--SMNPDDESSDTFASASASYHSQTVERTDLPHTEG----DN-----SSCVSF 627
            |..:...:||.|  ::.|.|....|.:.      .::|....|...||    |:     ...:||
  Rat   833 SGRKPHKTPLPATETLRPTDSGRLTESM------RRSVSEAALAQPEGLLGTDSLKKLTIKDLSF 891

  Fly   628 EDDSQPIVHYPIEISADPPKDTASAAYIDNFLDKYLIDTATMEVTEETAPEAVQ---AQANGHAK 689
            :.:|:|         :|.|:.:.|                 ||....:.|..|.   ...|...:
  Rat   892 KGNSEP---------SDSPEMSQS-----------------METLGPSTPSDVNFFLRSGNSQEE 930

  Fly   690 ISSDDDILVETGRDLVAIDTLQGRLQEAVNNITNTLTRCTQSYEIHGSNVMAQQDVRNMDALIAR 754
            ..:.|||                   ..::.|..........:....|:    |.|.:|.  :..
  Rat   931 AETRDDI-------------------SPMDGIPRVRAAFPDGFHPRRSS----QGVLHMP--LYS 970

  Fly   755 SPSEEFAFDVPKDPFLSPYWASDEWLSQLPETKILTLNMDPCLDDCVMFAKKLKRLGRQVDLEIL 819
            ||       :.|:||:||..|.|..|..||...::...:||.|||.||||::||.||:.|.|:::
  Rat   971 SP-------IVKNPFMSPLLAPDVMLKTLPPVHLVACALDPMLDDSVMFARRLKDLGQPVTLKVV 1028

  Fly   820 EGLPHGFLNFTMLSNEAMEGSKKCIKSLQTLL 851
            |.||||||:...|..|..:.::.|::.::.:|
  Rat  1029 EDLPHGFLSLAALCRETRQAAELCVQRIRLIL 1060

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HslNP_611463.1 HSL_N 51..376 CDD:461882 107/334 (32%)
alpha/beta hydrolases 395..>539 CDD:473884 84/143 (59%)
Aes <767..838 CDD:440422 33/70 (47%)
LipeNP_036991.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..76
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 91..195
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 236..278 2/2 (100%)
HSL_N 306..614 CDD:461882 107/331 (32%)
Aes 634..>764 CDD:440422 73/129 (57%)
Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole. /evidence=ECO:0000250|UniProtKB:Q5NUF3 649..651 1/1 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 836..862 6/31 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 890..913 9/48 (19%)
Blue background indicates that the domain is not in the aligned region.

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