Protein Alignment Hsl and Aadacl3

DIOPT Version :9

• Sequence 1: NP_611463.1
• Gene: Hsl / 37289
• FlyBaseID: FBgn0034491
• Length: 881
• Species: Drosophila melanogaster
• Sequence 2: NP_001078972.1
• Gene: Aadacl3 / 230883
• MGIID: 2685281
• Length: 408
• Species: Mus musculus
• Alignment Length: 521
• Identity: 97/521 - (18%)
• Similarity: 151/521 - (28%)
• Gaps: 226/521 - (43%)

  Fly   336 DVNQNQGDGDFVEIPVPTAHLGPGLPVSVRLLSARRRSGMLGEGRYRGWHKPIPPSP----SILF 396
            |:...:.|.|.|   |...|.|. :||.:                    :||..||.    .|:|
Mouse    78 DLKPLKRDPDVV---VKDLHFGT-IPVKL--------------------YKPKKPSSIPRLGIIF 118

  Fly   397 HCHGGGFVAQSSKSHELYLRDWAVALDCPILSVDYSLAPEAPFPRALQEVYYAYCWLLNNTELLG 461
            . ||||.:..|.::|.......:...|..::||.|..:|...:|....:...|....|.:.::.|
Mouse   119 F-HGGGTIIGSLRTHNSICLRLSKECDSVVVSVGYRKSPMYKYPVMKDDCVVATTHFLESLDVYG 182

  Fly   462 TTAERVVCAGDSAGANLSIGVALKCIEQGVRVPDGLFLAYCPTLVSFVPSPARLLCLMDPLLPFG 526
            ....|||..|||.|     |.|.....|        .|.:.|.|...     :...|:.|||.
Mouse   183 VDPARVVTCGDSVG-----GTAATVTSQ--------MLVHRPDLPRI-----KAQILIYPLLQ-- 227

  Fly   527 FMMRCLRAYAAPAQETLQQNAKQVEDAAQIRNVPKSNVGSLNSSRRTSMARSPLSPLEASMNPDD 591
                 |..:.:|   :.|||          ||:|
Mouse   228 -----LIDFGSP---SYQQN----------RNIP------------------------------- 243

  Fly   592 ESSDTFASASASYHSQTVERTDLPHTEGDNSSC--------VSFEDDSQPIVHYPIEISADPPKD 648
                 ..|...:::                  |        :|::...:..:|.|.::
Mouse   244 -----LLSWDLAFY------------------CFCCHLDVNISWKSVVKNGMHLPPDV------- 278

  Fly   649 TASAAYIDNFLDKYLIDTATMEVTEETAPEAVQAQANGHAKI---SSDDDILVETGRDLVAIDTL 710
                      .:||     ...:..|..||  :.:..|:..|   ..::|...|..|.|
Mouse   279 ----------WEKY-----RKWLGAENIPE--RFKNRGYKSIPWGPVNNDAYQEIKRSL------ 320

  Fly   711 QGRLQEAVNNITNTLTRCTQSYEIHGSNVMAQQDVRNMDALIARSPSEEFAFDVPKDPFLSPYWA 775
                     |.|     |                                          ||..:
Mouse   321 ---------NYT-----C------------------------------------------SPLIS 329

  Fly   776 SDEWLSQLPETKILTLNMDPCLDDCVMFAKKLKRLGRQVDLE--------ILEGLPHGFLNFTML 832
            .|..:||||||.|::...|...|..:::.|:|:.||..|...        :|..|.:|.|:|...
Mouse   330 EDSIVSQLPETCIVSCEYDLLRDHSLLYKKRLEDLGVPVTWHHMEDGFHGVLSALDYGLLSFPCA 394

  Fly   833 S 833
            |
Mouse   395 S 395

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsl	NP_611463.1	HSL_N	51..376	CDD:283906	9/39 (23%)
		Aes	350..>537	CDD:223730	44/190 (23%)
		Abhydrolase	395..>539	CDD:304388	34/143 (24%)
		Abhydrolase	<767..827	CDD:304388	20/67 (30%)
Aadacl3	NP_001078972.1	Aes	68..408	CDD:223730	97/521 (19%)
		Abhydrolase_3	116..379	CDD:285143	78/441 (18%)
		Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole. /evidence=ECO:0000250|UniProtKB:Q5NUF3	120..122		1/1 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0657
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263520at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820