DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsl and Lipe

DIOPT Version :9

Sequence 1:	NP_611463.1	Gene:	Hsl / 37289	FlyBaseID:	FBgn0034491	Length:	881	Species:	Drosophila melanogaster
Sequence 2:	XP_006539633.2	Gene:	Lipe / 16890	MGIID:	96790	Length:	1057	Species:	Mus musculus

Alignment Length:	901	Identity:	282/901 - (31%)
Similarity:	425/901 - (47%)	Gaps:	156/901 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DAASAERASPQFIALFNDNLKLGHEDDGPQAVNGKDT----HQHV---------PADLEATYGTL 54
            :.|...:..|:|..|.....||.|         ||.|    |:|.         ..||.....:|
Mouse   253 EMALLSKKKPEFEKLSGYGGKLPH---------GKKTSIQKHKHYWDTASAFSHSMDLRTMTQSL 308

  Fly    55 YAACQDHAAFF-ARDHTEFGQRLHAAHIAWQDFIVLANRLVQQIDAFAHEYDFDEQTPGNGYRSF 118
            ....:|:.||| ::...|..:||.......::..:.....:.|:...||.:|.|.:||.|||||.
Mouse   309 VTLAEDNMAFFSSQGPGETARRLSNVFAGVREQALGLEPTLGQLLGVAHHFDLDTETPANGYRSL 373

  Fly   119 IYVTNACIAHGISICQQLTATRSTIFFRKKFYMKEVEACSQLLSSLCTCLQY---LLILRQWSAS 180
            ::....|:||.:...:.:.:.|.:||||....:.|:||....|:.|.....|   ||.:.:
Mouse   374 VHTARCCLAHLLHKSRYVASNRKSIFFRASHNLAELEAYLAALTQLRAMAYYAQRLLTINR---- 434

  Fly   181 TGDLFACGNH--TAEQLFELGDTINQYCFYGRCLGFQYGDSIRGVLRFLGISMASYSESYYSQEG 243
            .|.||..|:.  ||:.|.|. .|:::.||||||||||:..:||..|:.|.|.:.|:.|.|  :..
Mouse   435 PGVLFFEGDEGLTADFLQEY-VTLHKGCFYGRCLGFQFTPAIRPFLQTLSIGLVSFGEHY--KRN 496

  Fly   244 DGPIVKTTRSLWTSGKYLMNPELRARRIVNISQNAKIDFCKSFWFLAESEMMHKLPSIVGSSIKV 308
            :..:..|..||:|.|::.::||||......|.||..:.|.|:||.:.|.|::..|.::..::::|
Mouse   497 ETGLSVTASSLFTGGRFAIDPELRGAEFERIIQNLDVHFWKAFWNITEIEVLSSLANMASTTVRV 561

  Fly   309 NRLIELPAEPLKLPRRKNFKASDNLSSDVNQNQGDGDFVEIPVPTAHLGPGLPVSVRLLSARRRS 373
            :||:.||.|..::|          |:||....      |.|..|.||.||. ||..||:|...|.
Mouse   562 SRLLSLPPEAFEMP----------LTSDPRLT------VTISPPLAHTGPA-PVLARLISYDLRE 609

  Fly   374 GM---------LGEG---RYRGWHKPIPPSPSILFHCHGGGFVAQSSKSHELYLRDWAVALDCPI 426
            |.         ..||   ..|......|.|.:::.|.||||||||:|||||.||::||..|..||
Mouse   610 GQDSKVLNSLAKSEGPRLELRPRPHQAPRSRALVVHIHGGGFVAQTSKSHEPYLKNWAQELGVPI 674

  Fly   427 LSVDYSLAPEAPFPRALQEVYYAYCWLLNNTELLGTTAERVVCAGDSAGANLSIGVALKCIEQGV 491
            .|:||||||||||||||:|.::||||.:.:.:|||:|.||:..||||||.||.|.|:|:....||
Mouse   675 FSIDYSLAPEAPFPRALEECFFAYCWAVKHCDLLGSTGERICLAGDSAGGNLCITVSLRAAAYGV 739

  Fly   492 RVPDGLFLAYCPTLVSFVPSPARLLCLMDPLLPFGFMMRCLRAYA-APAQETLQQNAK------- 548
            |||||:..||..|.:....||:|||.|||||||...:.:|:.||: ..|::....:.|
Mouse   740 RVPDGIMAAYPVTTLQSSASPSRLLSLMDPLLPLSVLSKCVSAYSGTEAEDHFDSDQKALGVMGL 804

  Fly   549 -QVEDAAQIRNVPKSNVGSLNSSRRTSMARSP---LSPLEASMNPDDESSDTFASASASYHSQTV 609
             |.:.:..:|::.......|||....| .|.|   .||...|:.|.:..            .::|
Mouse   805 VQRDTSLFLRDLRLGASSWLNSFLELS-GRKPQKTTSPTAESVRPTESM------------RRSV 856

  Fly   610 ERTDLPHTEG----DNSSCVSFED--DSQPIVHYPIEISADPPKDTASAAYIDNFLDKYLIDTAT 668
            ....|...||    |....::.:|  :|:|         :|.|:.:.|
Mouse   857 SEAALAQPEGLLGTDTLKKLTIKDLSNSEP---------SDSPEMSQS----------------- 895

  Fly   669 MEVTEETAPEAVQ---AQANGHAKISSDDDILVETGRDLVAIDTLQGRLQEAVNNITNTLTRCTQ 730
            ||....:.|..|.   ...|...:..:.|::     |.:..:..::....|.
Mouse   896 METLGPSTPSDVNFFLRPGNSQEEAEAKDEV-----RPMDGVPRVRAAFPEG------------- 942

  Fly   731 SYEIHGSNVMAQQDVRNMDALIARSPSEEFAFDVPKDPFLSPYWASDEWLSQLPETKILTLNMDP 795
               .|...  :.|.|.:|.  :..||       :.|:||:||..|.|..|..||...::...:||
Mouse   943 ---FHPRR--SSQGVLHMP--LYTSP-------IVKNPFMSPLLAPDSMLKTLPPVHLVACALDP 993

  Fly   796 CLDDCVMFAKKLKRLGRQVDLEILEGLPHGFLNFTMLSNEAMEGSKKCIKSLQTLL 851
            .|||.||||::|:.||:.|.|:::|.||||||:...|..|..:.::.|::.::.:|
Mouse   994 MLDDSVMFARRLRDLGQPVTLKVVEDLPHGFLSLAALCRETRQATEFCVQRIRLIL 1049

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsl	NP_611463.1	HSL_N	51..376	CDD:283906	106/339 (31%)
		Aes	350..>537	CDD:223730	100/199 (50%)
		Abhydrolase	395..>539	CDD:304388	83/144 (58%)
		Abhydrolase	<767..827	CDD:304388	28/59 (47%)
Lipe	XP_006539633.2	HSL_N	304..612	CDD:368853	106/331 (32%)
Lipe	XP_006539633.2	Abhydrolase	643..>791	CDD:389770	84/147 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850260
Domainoid	1	1.000	179	1.000	Domainoid score	I3517
eggNOG	1	0.900	-	-		E1_COG0657
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	401	1.000	Inparanoid score	I1921
Isobase	1	0.950	-	0.946395	Normalized mean entropy	S6559
OMA	1	1.010	-	-		QHG48026
OrthoDB	1	1.010	-	-		D1263520at2759
OrthoFinder	1	1.000	-	-		FOG0006107
OrthoInspector	1	1.000	-	-		oto95184
orthoMCL	1	0.900	-	-		OOG6_105723
Panther	1	1.100	-	-	LDO	PTHR23025
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4227
SonicParanoid	1	1.000	-	-		X4404
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.750