DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Hsl and AADAC

DIOPT Version :9

Sequence 1:NP_611463.1 Gene:Hsl / 37289 FlyBaseID:FBgn0034491 Length:881 Species:Drosophila melanogaster
Sequence 2:NP_001077.2 Gene:AADAC / 13 HGNCID:17 Length:399 Species:Homo sapiens


Alignment Length:522 Identity:103/522 - (19%)
Similarity:165/522 - (31%) Gaps:213/522 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly   344 GDFVEIPVPTAHLGPGLP------VSVRLLSARRRSGMLGEGRYRGWHKPIPPSPSILFHCHGGG 402
            |.|.|:| ||:.....:.      :.||:...:|:|..|..|               ||:.||||
Human    66 GSFDEVP-PTSDENVTVTETKFNNILVRVYVPKRKSEALRRG---------------LFYIHGGG 114

  Fly   403 FVAQSS--KSHELYLRDWAVALDCPILSVDYSLAPEAPFPRALQEVYYAYCWLLNNTEL--LGTT 463
            :...|:  ..::|..|..|..||..::|.:|.|||:..||...::||.|..|.|....|  .|..
Human   115 WCVGSAALSGYDLLSRWTADRLDAVVVSTNYRLAPKYHFPIQFEDVYNALRWFLRKKVLAKYGVN 179

  Fly   464 AERVVCAGDSAGANLSIGVALKCIEQGVRVPDGLFLAYCPTLVSFVPSPARLLCLMDPLLPFGFM 528
            .||:..:|||||.||:..|..:.::.    ||             |....::..|:.|       
Human   180 PERIGISGDSAGGNLAAAVTQQLLDD----PD-------------VKIKLKIQSLIYP------- 220

  Fly   529 MRCLRAYAAPAQETLQQNAKQVEDAAQIRNVPKSNVGSLNSSRRTSMARSPLSPLEASMNPDDES 593
                                                              .|.||:         
Human   221 --------------------------------------------------ALQPLD--------- 226

  Fly   594 SDTFASASASYHSQTVERTDLPHTEGDNSSCVSFEDDSQPIVHYPIEISADPPKDTASAAYIDNF 658
                              .|||          |::::|..:                       |
Human   227 ------------------VDLP----------SYQENSNFL-----------------------F 240

  Fly   659 LDKYLIDTATME--VTEETAPEAVQAQANGHAKISSDDDILVETGRDLVAIDTLQGRLQEAVNNI 721
            |.|.|:.....|  .|:.:..:|:.::.  |..:.|...........|:....::|.:....|  
Human   241 LSKSLMVRFWSEYFTTDRSLEKAMLSRQ--HVPVESSHLFKFVNWSSLLPERFIKGHVYNNPN-- 301

  Fly   722 TNTLTRCTQSYEIHGSNVMAQQ-----DVRNMDALIARSPSEEFAFDVPKDPFLSPYWASDEWLS 781
                         :||:.:|::     |||                       .:|..|.|..|.
Human   302 -------------YGSSELAKKYPGFLDVR-----------------------AAPLLADDNKLR 330

  Fly   782 QLPETKILTLNMDPCLDDCVMFAKKLKRLGRQVDLEILEGLPHGFLNFT------MLSNEAMEGS 840
            .||.|.::|...|...||.:|:..:|:..|.||....:|...||..:|.      .|.|:.:|..
Human   331 GLPLTYVITCQYDLLRDDGLMYVTRLRNTGVQVTHNHVEDGFHGAFSFLGLKISHRLINQYIEWL 395

  Fly   841 KK 842
            |:
Human   396 KE 397

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HslNP_611463.1 HSL_N 51..376 CDD:283906 10/37 (27%)
Aes 350..>537 CDD:223730 50/196 (26%)
Abhydrolase 395..>539 CDD:304388 41/147 (28%)
Abhydrolase <767..827 CDD:304388 19/59 (32%)
AADACNP_001077.2 Aes 33..399 CDD:223730 103/522 (20%)
Abhydrolase_3 107..377 CDD:285143 86/443 (19%)
Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole. /evidence=ECO:0000250|UniProtKB:Q5NUF3 111..113 1/1 (100%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0657
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1263520at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.820

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