Protein Alignment Hsl and AADAC

DIOPT Version :10

• Sequence 1: NP_611463.1
• Gene: Hsl / 37289
• FlyBaseID: FBgn0034491
• Length: 881
• Species: Drosophila melanogaster
• Sequence 2: NP_001077.2
• Gene: AADAC / 13
• HGNCID: 17
• Length: 399
• Species: Homo sapiens
• Alignment Length: 522
• Identity: 103/522 - (19%)
• Similarity: 165/522 - (31%)
• Gaps: 213/522 - (40%)

  Fly   344 GDFVEIPVPTAHLGPGLP------VSVRLLSARRRSGMLGEGRYRGWHKPIPPSPSILFHCHGGG 402
            |.|.|:| ||:.....:.      :.||:...:|:|..|..|               ||:.||||
Human    66 GSFDEVP-PTSDENVTVTETKFNNILVRVYVPKRKSEALRRG---------------LFYIHGGG 114

  Fly   403 FVAQSS--KSHELYLRDWAVALDCPILSVDYSLAPEAPFPRALQEVYYAYCWLLNNTEL--LGTT 463
            :...|:  ..::|..|..|..||..::|.:|.|||:..||...::||.|..|.|....|  .|..
Human   115 WCVGSAALSGYDLLSRWTADRLDAVVVSTNYRLAPKYHFPIQFEDVYNALRWFLRKKVLAKYGVN 179

  Fly   464 AERVVCAGDSAGANLSIGVALKCIEQGVRVPDGLFLAYCPTLVSFVPSPARLLCLMDPLLPFGFM 528
            .||:..:|||||.||:..|..:.::.    ||             |....::..|:.|
Human   180 PERIGISGDSAGGNLAAAVTQQLLDD----PD-------------VKIKLKIQSLIYP------- 220

  Fly   529 MRCLRAYAAPAQETLQQNAKQVEDAAQIRNVPKSNVGSLNSSRRTSMARSPLSPLEASMNPDDES 593
                                                              .|.||:
Human   221 --------------------------------------------------ALQPLD--------- 226

  Fly   594 SDTFASASASYHSQTVERTDLPHTEGDNSSCVSFEDDSQPIVHYPIEISADPPKDTASAAYIDNF 658
                              .|||          |::::|..:                       |
Human   227 ------------------VDLP----------SYQENSNFL-----------------------F 240

  Fly   659 LDKYLIDTATME--VTEETAPEAVQAQANGHAKISSDDDILVETGRDLVAIDTLQGRLQEAVNNI 721
            |.|.|:.....|  .|:.:..:|:.::.  |..:.|...........|:....::|.:....|
Human   241 LSKSLMVRFWSEYFTTDRSLEKAMLSRQ--HVPVESSHLFKFVNWSSLLPERFIKGHVYNNPN-- 301

  Fly   722 TNTLTRCTQSYEIHGSNVMAQQ-----DVRNMDALIARSPSEEFAFDVPKDPFLSPYWASDEWLS 781
                         :||:.:|::     |||                       .:|..|.|..|.
Human   302 -------------YGSSELAKKYPGFLDVR-----------------------AAPLLADDNKLR 330

  Fly   782 QLPETKILTLNMDPCLDDCVMFAKKLKRLGRQVDLEILEGLPHGFLNFT------MLSNEAMEGS 840
            .||.|.::|...|...||.:|:..:|:..|.||....:|...||..:|.      .|.|:.:|..
Human   331 GLPLTYVITCQYDLLRDDGLMYVTRLRNTGVQVTHNHVEDGFHGAFSFLGLKISHRLINQYIEWL 395

  Fly   841 KK 842
            |:
Human   396 KE 397

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsl	NP_611463.1	HSL_N	51..376	CDD:461882	10/37 (27%)
		alpha/beta hydrolases	395..>539	CDD:473884	41/147 (28%)
		Aes	<767..838	CDD:440422	22/76 (29%)
AADAC	NP_001077.2	Abhydrolase_3	107..374	CDD:400284	84/440 (19%)
		Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole. /evidence=ECO:0000250|UniProtKB:Q5NUF3	111..113		1/1 (100%)