Protein Alignment Hsl and AADACL3

DIOPT Version :9

• Sequence 1: NP_611463.1
• Gene: Hsl / 37289
• FlyBaseID: FBgn0034491
• Length: 881
• Species: Drosophila melanogaster
• Sequence 2: NP_001096640.2
• Gene: AADACL3 / 126767
• HGNCID: 32037
• Length: 407
• Species: Homo sapiens
• Alignment Length: 540
• Identity: 100/540 - (18%)
• Similarity: 156/540 - (28%)
• Gaps: 237/540 - (43%)

  Fly   347 VEIPVPTAHLGPGLPVSVRLLSARRRS----GMLGE-------GRYRGWHKPIPP---------- 390
            |.||....|     ||.:|:|....:.    ||:.|       .::..:.:.:||
Human    31 VHIPAAVGH-----PVKLRVLHCIFQLLLTWGMIFEKLRICSMPQFFCFMQDLPPLKYDPDVVVT 90

  Fly   391 ---------------------SPSILFHCHGGGFVAQSSKSHELYLRDWAVALDCPILSVDYSLA 434
                                 .|.|::: ||||.|..|.|:|...........|..:|:|.|...
Human    91 DFRFGTIPVKLYQPKASTCTLKPGIVYY-HGGGGVMGSLKTHHGICSRLCKESDSVVLAVGYRKL 154

  Fly   435 PEAPFPRALQEVYYAYCWLLNNTELLGTTAERVVCAGDSAGANLSIGVALKCIEQGVRVPDGLFL 499
            |:..||..:::...|....|.:.:..|....|||..|||.|..::   |:.| :|.|..||
Human   155 PKHKFPVPVRDCLVATIHFLKSLDAYGVDPARVVVCGDSFGGAIA---AVVC-QQLVDRPD---- 211

  Fly   500 AYCPTLVSFVPSPARLLCLMDPLLPFGFMMRCLRAYAAPAQETLQQNAKQVEDAAQIRNVPKSNV 564
              .|.:      .|::|                 .||     .||....|.....|.:|:|...
Human   212 --LPRI------RAQIL-----------------IYA-----ILQALDLQTPSFQQRKNIPLLT- 245

  Fly   565 GSLNSSRRTSMARSPLSPLEASMNPDDESSDTFASASASYHSQTVERTDLPHTEGDNSSCVSFED 629
                                             .|....:..|.::                |..
Human   246 ---------------------------------WSFICYFFFQNLD----------------FSS 261

  Fly   630 DSQPIV----HYPIEISADPPKDTASAAYIDNFLDKYLIDTATMEVTEETAPEAVQAQANGHAKI 690
            ..|.::    |.|.|:                 .:||
Human   262 SWQEVIMKGAHLPAEV-----------------WEKY---------------------------- 281

  Fly   691 SSDDDILVETGRDLVAIDTLQGRLQEAVNNITNTLTRCTQSYEIHGSNVMAQQDVRNMDALIARS 755
                       |..:..:.:..|.:|             :.|:                 |....
Human   282 -----------RKWLGPENIPERFKE-------------RGYQ-----------------LKPHE 305

  Fly   756 PSEEFAF---DVPKDPFLSPYWASDEWLSQLPETKILTLNMDPCLDDCVMFAKKLKRLGRQVDLE 817
            |..|.|:   .|..|...||..|.|:.:||||||.|::...|...|:.:::.|:|:.||..|...
Human   306 PMNEAAYLEVSVVLDVMCSPLIAEDDIVSQLPETCIVSCEYDALRDNSLLYKKRLEDLGVPVTWH 370

  Fly   818 ILEGLPHG--------FLNF 829
            .:|...||        ||:|
Human   371 HMEDGFHGVLRTIDMSFLHF 390

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsl	NP_611463.1	HSL_N	51..376	CDD:283906	9/32 (28%)
		Aes	350..>537	CDD:223730	48/228 (21%)
		Abhydrolase	395..>539	CDD:304388	36/143 (25%)
		Abhydrolase	<767..827	CDD:304388	22/67 (33%)
AADACL3	NP_001096640.2	Abhydrolase_3	115..378	CDD:311692	81/437 (19%)
		Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole. /evidence=ECO:0000250|UniProtKB:Q5NUF3	119..121		1/1 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0657
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263520at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820