DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ate1 and Ate1

DIOPT Version :9

Sequence 1:	NP_001261101.1	Gene:	Ate1 / 37288	FlyBaseID:	FBgn0025720	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	XP_038963481.1	Gene:	Ate1 / 293526	RGDID:	1309335	Length:	520	Species:	Rattus norvegicus

Alignment Length:	527	Identity:	213/527 - (40%)
Similarity:	297/527 - (56%)	Gaps:	64/527 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SLSIVSYYGSQQS-KCGYCAGANCSLSHGMHAYQLDCRDYQDLIDRGWRRCGYYCYKLRNQETCC 65
            |.|:|.|:..|.| :||||.....|.||||.|:.:..:||||||||||||.|.|.||....:|||
  Rat     8 SPSLVEYFEGQTSFQCGYCKSNFGSRSHGMWAHSMTVQDYQDLIDRGWRRSGKYVYKPVMNQTCC 72

  Fly    66 PCYTIKCNGLEFKLSKSNKRILRRINRFLRDGK-----RESKPEAGDGDGEADADYAI------- 118
            |.|||:|:.|:|:.|||:|::|:::.:||..|:     .|.:|.....:...|.|:|:
  Rat    73 PQYTIRCHPLQFQPSKSHKKVLKKMLKFLAKGEISKGNCEDEPMDSTMEDAVDGDFALMNKLDIK 137

  Fly   119 -----VAPEVTAS-EPQPQLPDKSPPVINVEQVASLATAQRKPTKQATAAAVEAPTLGSNKSSLL 177
                 ::.::..| |.:.:..:||   :..|....|...|          |:| ..|||.:.|..
  Rat   138 CDLKTLSSDLKVSIESEEKEKEKS---LKKEGSKDLIHPQ----------AIE-EKLGSGEPSHS 188

  Fly   178 -------SSSAAAPISNKPCKKAKQMRLDRRLAKL---------------GDSASYSTKSLT-QE 219
                   .....|.:|..||:|||:||.:|:..||               |...|...|:.: |.
  Rat   189 IKVHVGPKPGKGADLSKPPCRKAKEMRKERKRLKLMQQSSAGAFEGFQAQGQPVSLLPKAKSNQP 253

  Fly   220 KTLRDFL-NTDSETNKHRLKIVLVASSDTE---RTCADAVIALYRKYQITVHNDNPARLTLASMQ 280
            |:|.|.: .:..|...|:|::.:|.||...   :........:|::||:.:|.|.|.:.|::...
  Rat   254 KSLEDLIFESLPEDASHKLEVRVVRSSPPSPQFKATFQESYQVYKRYQMIIHKDPPDKPTVSQFT 318

  Fly   281 RFLVKSPLKNEKPWDGPEMGYGSFHQQYWLDDKLIAVGVIDILPGCVSSVYFFYDPDYSFLSLGT 345
            |||..|||:.|.|.:|||.||||||||||||.|:||||||||||.||||||.:|||||||||||.
  Rat   319 RFLCNSPLEAEHPANGPECGYGSFHQQYWLDGKIIAVGVIDILPYCVSSVYLYYDPDYSFLSLGV 383

  Fly   346 YGSLREIELVQSLAEKVPSLKYYYMGFYIHSCPKMRYKGKLSPSYLLCPETYEWLPLTDVIRAKL 410
            |.:||||...:.|.||...|.||||||||||||||||||:..||.|||||||.|:|:...: ..|
  Rat   384 YSALREIAFTRQLHEKTSQLSYYYMGFYIHSCPKMRYKGQYRPSDLLCPETYVWVPIEQCL-PSL 447

  Fly   411 DEHKYQRLNEDPAARDVNEFLMEHLDEVKLLLGGRTRTDYKHFRQLRGTVSDDDIIIEYSKLVGK 475
            |..||.|.|:||.|.|  |...:.||.:: :...|:...|..::..:...|::.:::||:.|||:
  Rat   448 DNSKYCRFNQDPQAED--EGRSKELDRLR-VFHRRSAMPYGVYKNHQEDPSEEAVVLEYANLVGQ 509

  Fly   476 ECARRML 482
            :|:..||
  Rat   510 KCSETML 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ate1	NP_001261101.1	ATE_N	14..85	CDD:282259	40/71 (56%)
Ate1	NP_001261101.1	ATE_C	256..395	CDD:282260	90/138 (65%)
Ate1	XP_038963481.1	ATE_N	23..92	CDD:398189	39/68 (57%)
Ate1	XP_038963481.1	ATE_C	292..431	CDD:398190	94/138 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	190	1.000	Domainoid score	I3188
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31420
Inparanoid	1	1.050	349	1.000	Inparanoid score	I2222
OMA	1	1.010	-	-		QHG55132
OrthoDB	1	1.010	-	-		D1446907at2759
OrthoFinder	1	1.000	-	-		FOG0004464
OrthoInspector	1	1.000	-	-		oto98523
orthoMCL	1	0.900	-	-		OOG6_103364
Panther	1	1.100	-	-	LDO	PTHR21367
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3164
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.980