DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9864 and SLC17A6

DIOPT Version :9

Sequence 1:	NP_001261100.1	Gene:	CG9864 / 37287	FlyBaseID:	FBgn0034490	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	NP_065079.1	Gene:	SLC17A6 / 57084	HGNCID:	16703	Length:	582	Species:	Homo sapiens

Alignment Length:	459	Identity:	149/459 - (32%)
Similarity:	258/459 - (56%)	Gaps:	13/459 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 CFYVPKRINLAIMLFMACLLSYMMRVNLSINIIAMVEDTSSHENGTEVEALPDYGPRYNWTQSDQ 70
            ||.:|:|..:|||..:...:|:.:|.||.:.|:.||.:::.|..|..::.    ..::||.....
Human    64 CFGLPRRYIIAIMSGLGFCISFGIRCNLGVAIVDMVNNSTIHRGGKVIKE----KAKFNWDPETV 124

  Fly    71 ALLLGAYFYGYMITSLPAGTLAEMLGARNVAGYSCLVAGILTALTPAAAAWDKYAVFAVRFLIGF 135
            .::.|::|:||:||.:|.|.:|..|.|..|.|.:.|:...|..|.|:||......|..||.|.|.
Human   125 GMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIPSAARVHYGCVIFVRILQGL 189

  Fly   136 LNGVVYPCCHSLVSKWSPPDEKGKFVASLMGGTF-GTVITWPISGVIIENLGWDWAFYIVGIFVL 199
            :.||.||.||.:.|||:||.|:.:...:...|:: |.||..|::|::::..||...||:.|.|.:
Human   190 VEGVTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFGM 254

  Fly   200 VVVAIWFYLVADTPAQHSTISLKEREYIESSLGDT---LSNKKKW-PPYKELVLSLPFWSLMMLH 260
            |....|..:..::||:|.||:.:||.|||.|:|::   |...:|: .|:::...|:|.:::::.:
Human   255 VWYMFWLLVSYESPAKHPTITDEERRYIEESIGESANLLGAMEKFKTPWRKFFTSMPVYAIIVAN 319

  Fly   261 YGSMWGLFFLITATPKFLSEVLGFNLSSAGFLSSLPH-VARLLCAFGFGAVADWIRRRGWLSVTR 324
            :...|..:.|:.:.|.:..||.||.:|..|.||::|| |..::...| |.:||::|.:..||.|.
Human   320 FCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAVPHLVMTIIVPIG-GQIADFLRSKQILSTTT 383

  Fly   325 MRKAFCLPSHILPGVMLIILAYFGRDPYVCVAIMTISLGFNGAATASNLANSQDLAPNYAGTLYG 389
            :||........:...:|:::.| .....|.::.:.:::||:|.|.:....|..|:||.||..|.|
Human   384 VRKIMNCGGFGMEATLLLVVGY-SHTRGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMG 447

  Fly   390 IINCVGTTPGIFSPLIVAAFTKNENTIDQWHWVFIIGAAAYILPALFFWVFGSGKIQKWNEVQTT 454
            |.|.|||..|:..|:||.|.|||::. ::|.:||:|.|..:....:|:.:|.||:.|.|.:.:.|
Human   448 ISNGVGTLSGMVCPIIVGAMTKNKSR-EEWQYVFLIAALVHYGGVIFYAIFASGEKQPWADPEET 511

  Fly   455 ESRE 458
            ...:
Human   512 SEEK 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9864	NP_001261100.1	2A0114euk	4..454	CDD:129972	148/453 (33%)
CG9864	NP_001261100.1	MFS	55..440	CDD:119392	127/390 (33%)
SLC17A6	NP_065079.1	MFS_SLC17A6_7_8_VGluT	74..498	CDD:340940	139/430 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D497052at2759
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820