DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9864 and VGlut

DIOPT Version :9

Sequence 1:	NP_001261100.1	Gene:	CG9864 / 37287	FlyBaseID:	FBgn0034490	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	NP_001245848.1	Gene:	VGlut / 33427	FlyBaseID:	FBgn0031424	Length:	632	Species:	Drosophila melanogaster

Alignment Length:	460	Identity:	134/460 - (29%)
Similarity:	226/460 - (49%)	Gaps:	28/460 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PCFYVPKRINLAIMLFMACLLSYMMRVNLSINIIAMVEDTSSHENGTEVEALPDYGPRYNWTQSD 69
            ||  :|.|..:|.|..:..::::.||.|:|      ........|||..         .|||.:.
  Fly    90 PC--MPARYTIATMACVGFMIAFGMRCNMS------AAKLKGEHNGTVF---------MNWTVAV 137

  Fly    70 QALLLGAYFYGYMITSLPAGTLAEMLGARNVAGYSCLVAGILTALTP-AAAAWDKYAVFAVRFLI 133
            ::.:..::|:||::|.:|.|.:|....|..:.|.|.:.:..|....| |......:.|..||.|.
  Fly   138 ESHVDSSFFWGYLVTQIPGGFIASKFPANKIFGLSIVSSATLHLFVPFAMTLMHGHVVICVRVLQ 202

  Fly   134 GFLNGVVYPCCHSLVSKWSPPDEKGKFVASLMGGTF-GTVITWPISGVIIENLGWDWAFYIVGIF 197
            |...||.||.||.:...|:||.|:.:.......|:: |.|:..|:||::.:.:|:...||..|:|
  Fly   203 GLFEGVTYPACHGIWRFWAPPMERSRLATLAFSGSYAGVVVGLPLSGLLADAVGYQAPFYAYGVF 267

  Fly   198 VLVVVAIWFYLVADTPAQHSTISLKEREYIESSLGD----TLSNKKKWPPYKELVLSLPFWSLMM 258
            .::....|.:|..:.|.:|..||:.|.:|||.|||:    |:.:.|. .|::|::.|:|.:::::
  Fly   268 GIIWYMFWIWLCFENPRKHPAISIPELKYIEKSLGESAHPTMPSLKT-TPWREMMRSMPVYAIIV 331

  Fly   259 LHYGSMWGLFFLITATPKFLSEVLGFNLSSAGFLSSLPH-VARLLCAFGFGAVADWIRRRGWLSV 322
            .::...|..:.|:.....||....||.:..|||:.|||| :...:..|| |.:||.:|:.|.||.
  Fly   332 ANFCRSWNFYLLVLFQSSFLKHKFGFKVEEAGFVGSLPHLIMTTIVPFG-GMLADHLRKNGILST 395

  Fly   323 TRMRKAFCLPSHILPGVMLIILAYFGRDPYVCVAIMTISLGFNGAATASNLANSQDLAPNYAGTL 387
            |.:||.|......:.|:..:.:|:.........| :|..:.|:|.|.:....|..|:||.||..|
  Fly   396 TNVRKLFNCGGFGMEGLFFLFVAHSSTATGAMFA-LTCGVAFSGFAISGYNVNHLDIAPRYASIL 459

  Fly   388 YGIINCVGTTPGIFSPLIVAAFTKNENTIDQWHWVFIIGAAAYILPALFFWVFGSGKIQKWNEVQ 452
            .|:.|.:||..||..|..:....: .|....|..||.:.|..:::...|:.:|.||::|.|.|..
  Fly   460 MGLSNGIGTLAGIIVPYALDGLIQ-ANPTGCWTTVFTLAACVHLVGCTFYGIFASGELQPWAEPP 523

  Fly   453 TTESR 457
            ..|.:
  Fly   524 AEEQK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9864	NP_001261100.1	2A0114euk	4..454	CDD:129972	133/455 (29%)
CG9864	NP_001261100.1	MFS	55..440	CDD:119392	114/391 (29%)
VGlut	NP_001245848.1	MFS	98..512	CDD:119392	123/432 (28%)
VGlut	NP_001245848.1	MFS_1	101..475	CDD:284993	115/391 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	116	1.000	Domainoid score	I288
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	134	1.000	Inparanoid score	I245
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D497052at2759
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	1	1.000	-	-		mtm14983
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	7.070