Protein Alignment ppk6 and SCNN1G

DIOPT Version :9

• Sequence 1: NP_611461.3
• Gene: ppk6 / 37286
• FlyBaseID: FBgn0034489
• Length: 498
• Species: Drosophila melanogaster
• Sequence 2: NP_001030.2
• Gene: SCNN1G / 6340
• HGNCID: 10602
• Length: 649
• Species: Homo sapiens
• Alignment Length: 584
• Identity: 127/584 - (21%)
• Similarity: 198/584 - (33%)
• Gaps: 179/584 - (30%)

  Fly    51 WLMRRNRTYGLSRFIWS-SVLLQLLLLSIYLT---LLLW----LKFYSYPILNTISNDLSITDVA 107
            |......|:|..|.:.| ..|.:||.:...||   |:||    |.|..|.:  ::|..:....:.
Human    31 WYCLNTNTHGCRRIVVSRGRLRRLLWIGFTLTAVALILWQCALLVFSFYTV--SVSIKVHFRKLD 93

  Fly   108 FPGVTICSPKVVNSERVDRYVKTLKIPKEYDMAEVIA---GF----------------------- 146
            ||.||||:   :|..:... |:.|....|.:..|.:.   ||
Human    94 FPAVTICN---INPYKYST-VRHLLADLEQETREALKSLYGFPESRKRREAESWNSVSEGKQPRF 154

  Fly   147 ------------------DFLNAFTDQSFEPPGHDSYRATDAVLRLNNVSI--WEAAMAVSPGCF 191
                              ||   ||.:..:..|...::|:: |:.:.:..:  ::.....:..|.
Human   155 SHRIPLLIFDQDEKGKARDF---FTGRKRKVGGSIIHKASN-VMHIESKQVVGFQLCSNDTSDCA 215

  Fly   192 DY--------VKRCFWGH---------TEFQCNQSHEYLSFIPTTAYLGPCCSFNYNPRNASFV- 238
            .|        ::..:..|         .|.:.|.|:.....:.|..:.|..|    :.||.:..
Human   216 TYTFSSGINAIQEWYKLHYMNIMAQVPLEKKINMSYSAEELLVTCFFDGVSC----DARNFTLFH 276

  Fly   239 -PFSANIFGMDGGLTFVGAE----------GSERNLNTGLIVLVHHPMDY----VTEAAASVTIT 288
             |...|.:      ||...|          |||..|.   ::|..:..:|    |:...|.|.|.
Human   277 HPMHGNCY------TFNNRENETILSTSMGGSEYGLQ---VILYINEEEYNPFLVSSTGAKVIIH 332

  Fly   289 AQSE-SFVE-VSPTVQSSSV--------EVLELSERKRDCLISG-DLQLSNYRQAA-----CLLA 337
            .|.| .||| |...::::.|        |..:|||....|...| |:.:.|...||     ||.:
Human   333 RQDEYPFVEDVGTEIETAMVTSIGMHLTESFKLSEPYSQCTEDGSDVPIRNIYNAAYSLQICLHS 397

  Fly   338 CQTEAIVKKCGCHPYL--LPIVGNKFKECNL----NDTFCYSANYDNFKSVRCDQCLPNCYDVTY 396
            |....:|:||||..|.  ||...|   .||.    |..:||...:..|.....     .|..|..
Human   398 CFQTKMVEKCGCAQYSQPLPPAAN---YCNYQQHPNWMYCYYQLHRAFVQEEL-----GCQSVCK 454

  Fly   397 STLSYK-----TDLNQHKYSVSRFYSPELLNNDSFVLRVYLAKQVVPVIRKVTVMSWI------- 449
            ...|:|     |.|.|....||..:...:|..|.       .:||...:.|..:...:
Human   455 EACSFKEWTLTTSLAQWPSVVSEKWLLPVLTWDQ-------GRQVNKKLNKTDLAKLLIFYKDLN 512

  Fly   450 -------------GLLSDLGGIFNL---CLGLSMISVVEFFYYCTYRLYINYQLQKVQQPRKAW 497
                         .|||:.||...|   |..:.:|.::|.|:...:.:....|.||.    |.|
Human   513 QRSIMESPANSIEMLLSNFGGQLGLWMSCSVVCVIEIIEVFFIDFFSIIARRQWQKA----KEW 572

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk6	NP_611461.3	ASC	85..476	CDD:279230	110/523 (21%)
SCNN1G	NP_001030.2	ENaC	24..630	CDD:273304	127/584 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152122
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.750