Protein Alignment ppk6 and SCNN1D

DIOPT Version :9

• Sequence 1: NP_611461.3
• Gene: ppk6 / 37286
• FlyBaseID: FBgn0034489
• Length: 498
• Species: Drosophila melanogaster
• Sequence 2: NP_001123885.2
• Gene: SCNN1D / 6339
• HGNCID: 10601
• Length: 802
• Species: Homo sapiens
• Alignment Length: 554
• Identity: 120/554 - (21%)
• Similarity: 203/554 - (36%)
• Gaps: 126/554 - (22%)

  Fly     8 PTPGKKNSKGDGSRKRGKDPSLIRTAILATFWE----YTERTKVSGMWLMRRNRTYGLSRFIWSS 68
            |.||.. |......|.|....|:.  :.|:|.|    :.....:.|...:..:|...|....|..
Human   193 PRPGPP-SAPPPPPKEGHQEGLVE--LPASFRELLTFFCTNATIHGAIRLVCSRGNRLKTTSWGL 254

  Fly    69 VLLQLLLLSIYLTLLLWLKFYSYPILNTISNDLSITDVAFPGVTIC-------SPKVVNSERVDR 126
            :.|..|:...:...||:.:.:..|:|..:|  :.......|.||:|       ||.:.:.|.:|.
Human   255 LSLGALVALCWQLGLLFERHWHRPVLMAVS--VHSERKLLPLVTLCDGNPRRPSPVLRHLELLDE 317

  Fly   127 YVKTLKIPKEYDMAEVIAGFDFLNAFTDQSFEPPGHDSYRATDAVLRLNNVSIWEAAMAVSPG-- 189
            :.:. .|...|:: .:..|...|:| |....|||.|     .|..:||..:|  .:...|..|
Human   318 FARE-NIDSLYNV-NLSKGRAALSA-TVPRHEPPFH-----LDREIRLQRLS--HSGSRVRVGFR 372

  Fly   190 -CFDYVKRCFW-GHTE-FQCNQSHEYLSFIPTTAYLGPCCSFNYNPRNASFV------------- 238
             |......||: |:|. ....|...:..::...|.|......::..::..||
Human   373 LCNSTGGDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWEDSHGSQDGHFVLSCSYDGLDCQAR 437

  Fly   239 -------PFSANIFGMDG-------GLTFVGAEGSERNLNTGLIVLV----HHPMDYVTEAAASV 285
                   |...:.:.:||       |:|.          ..||::.|    |.|: ..|.|...|
Human   438 QFRTFHHPTYGSCYTVDGVWTAQRPGITH----------GVGLVLRVEQQPHLPL-LSTLAGIRV 491

  Fly   286 TITAQS-------ESFVEVSP----TVQSSSVEVLELSERKRDCLISGD------LQLSNYRQAA 333
            .:..::       .|| .|.|    |:.....||..|......|...|:      |..::|.:.|
Human   492 MVHGRNHTPFLGHHSF-SVRPGTEATISIREDEVHRLGSPYGHCTAGGEGVEVELLHNTSYTRQA 555

  Fly   334 CLLACQTEAIVKKCGCHPYLLPI-VGNKFKECNLNDTF--CYSANYDNFKSVR--C-DQCLPNCY 392
            ||::|..:.:|:.|.|..||.|: .|.::.....:..:  |:...|.:.::.|  | .:|...|.
Human   556 CLVSCFQQLMVETCSCGYYLHPLPAGAEYCSSARHPAWGHCFYRLYQDLETHRLPCTSRCPRPCR 620

  Fly   393 DVTYSTLSYKTDLNQHKYSVSRFYSPEL------------LNNDSFVLRVYLAKQVVPV------ 439
            :..:. ||..|         ||:.|.:.            |.:.|...|..|||..:..
Human   621 ESAFK-LSTGT---------SRWPSAKSAGWTLATLGEQGLPHQSHRQRSSLAKINIVYQELNYR 675

  Fly   440 -IRKVTVMSWIGLLSDLGGIFNLCLGLSMISVVE 472
             :.:..|.|...|||.:|.:.:|..|.|::|::|
Human   676 SVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLE 709

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk6	NP_611461.3	ASC	85..476	CDD:279230	102/473 (22%)
SCNN1D	NP_001123885.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	145..211		6/18 (33%)
		ENaC	219..784	CDD:273304	112/525 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	738..777

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152118
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.750