Protein Alignment ppk6 and SCNN1A

DIOPT Version :9

• Sequence 1: NP_611461.3
• Gene: ppk6 / 37286
• FlyBaseID: FBgn0034489
• Length: 498
• Species: Drosophila melanogaster
• Sequence 2: NP_001153048.1
• Gene: SCNN1A / 6337
• HGNCID: 10599
• Length: 728
• Species: Homo sapiens
• Alignment Length: 583
• Identity: 133/583 - (22%)
• Similarity: 218/583 - (37%)
• Gaps: 150/583 - (25%)

  Fly     9 TPG-----KKNSKGDGSRKRG-KDPSLIRTAILATFWEYTE-------RTKVSG---MWLMRRNR 57
            |||     |:..:|.|..... :.|:....|::.....|.|       .|.:.|   :...:.||
Human    76 TPGLMKGNKREEQGLGPEPAAPQQPTAEEEALIEFHRSYRELFEFFCNNTTIHGAIRLVCSQHNR 140

  Fly    58 TYGLSRFIWSSVLLQLLLLSIYLTLLLWLKFYSYPILNTISNDLSITDVAFPGVTICS------P 116
               :....|:.:.|....:..:...||:.:::|||:  :::.:|:...:.||.||||:      |
Human   141 ---MKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPV--SLNINLNSDKLVFPAVTICTLNPYRYP 200

  Fly   117 KVVNS-ERVDRYV-KTL-KIPKEYDMAEVIAGF----DFLNAFTDQ----SFEPPGHDSYRATDA 170
            ::... |.:||.. :|| .:.|......::||.    |........    ...||.|.:.||...
Human   201 EIKEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRRDLRGTLPHPLQRLRVPPPPHGARRARSV 265

  Fly   171 V--LRLNNVSI----WEAAMAVSPGCFDYVKRCFWGHTEFQCNQSHEY--------LSFIPTTA- 220
            .  ||.||..:    |:....:   |......||:.......:...|:        ||.:|.|.
Human   266 ASSLRDNNPQVDWKDWKIGFQL---CNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLPETLP 327

  Fly   221 -----YLGP---CCSFNYNPRN-ASFVPFSANIFGMDGGLTFVGAEGSE------RNLNTGL-IV 269
                 .||.   .|.||....| |::..|...::|  ...||.....|.      ..:|.|| ::
Human   328 SLEEDTLGNFIFACRFNQVSCNQANYSHFHHPMYG--NCYTFNDKNNSNLWMSSMPGINNGLSLM 390

  Fly   270 LVHHPMDYV----TEAAASVTITAQSE-SFVE-----VSPTVQSSSVEVLELSERKR-------- 316
            |.....|::    |...|.|.:..|.| :|::     :.|.|::|      :|.||.
Human   391 LRAEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETS------ISMRKETLDRLGGD 449

  Fly   317 --DCLISG------DLQLSNYRQAACLLACQTEAIVKKCGCHPYLLPIVGNKFKECNLND----T 369
              ||..:|      :|..|.|.|..|:.:|..|:::|:|||.....|...| .:.|:...    .
Human   450 YGDCTKNGSDVPVENLYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQN-VEYCDYRKHSSWG 513

  Fly   370 FCYSANYDNFKS------VRCDQ-CLPNCY----------DVTYSTLSYKTDLNQHKYSVSRFYS 417
            :||.....:|.|      .:|.: |....|          .||.....::....|:.|:|:
Human   514 YCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVN---- 574

  Fly   418 PELLNNDSFVLRV--------YLAKQVVPVIRKVTVMSWIGLLSDLGGIFNLCLGLSMISVVE 472
                |..:.|.:|        |......|.:..||      |||:||..::|..|.|::||||
Human   575 ----NKRNGVAKVNIFFKELNYKTNSESPSVTMVT------LLSNLGSQWSLWFGSSVLSVVE 627

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk6	NP_611461.3	ASC	85..476	CDD:279230	115/491 (23%)
SCNN1A	NP_001153048.1	ENaC	113..706	CDD:273304	125/546 (23%)
		deg-1	121..631	CDD:273309	123/538 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152126
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.750