DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk6 and Asic5

DIOPT Version :9

Sequence 1:	NP_611461.3	Gene:	ppk6 / 37286	FlyBaseID:	FBgn0034489	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	NP_067345.1	Gene:	Asic5 / 58170	MGIID:	1929259	Length:	495	Species:	Mus musculus

Alignment Length:	522	Identity:	114/522 - (21%)
Similarity:	203/522 - (38%)	Gaps:	135/522 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 EYTERTKVSGMWLMRRNRTYGLSRFIWSSVLL---QLLLLSIYLTLLLWLKFYSYPILNTISNDL 101
            ::...|...|:..:.:|:. .:.:.||.:|:|   .||:..||..|   :.::::|...:|....
Mouse    40 DFAMSTSFHGIHNIAQNQN-KVRKVIWLAVVLGSVSLLVWQIYSRL---VNYFTWPTTTSIEVQY 100

  Fly   102 SITDVAFPGVTICSPKVVNSERVDRY----------VKTLKIPKEYDMAEVIAG-------FDFL 149
             :..:.||.||:|:.....:|.|.|:          .|.|:      :.|:.|.       .||:
Mouse   101 -VEKIEFPAVTLCNLNRFQTEAVSRFGIIFFLWDIVSKVLR------LQEISANNTGSPETLDFV 158

  Fly   150 NAFTDQSFEPPGHDSYRATDAV----LRLNNVSIWEAAMAVSPGCFDYVKRC-FWGHTEFQCNQS 209
            .          .|.::..|:.|    ..|||               |.:..| |:|.|....:..
Mouse   159 T----------NHQNFSITEFVKNNGFYLNN---------------DTLVHCEFFGKTCSPKDFK 198

  Fly   210 HEYLSFIPTTAYLGPCCSFNY--NPRNASFVPFSANIFGMDGGLTF---VGAEGSERN-----LN 264
            |.:..:       |.|.:|||  |.:|.:.|..|..      ||..   |..|....|     .:
Mouse   199 HVFTEY-------GNCFTFNYGENIQNKNKVSVSGR------GLKLLLDVHQEEFTDNPVPGFAD 250

  Fly   265 TGLIVLVHHPMDYVTEAAASVTITAQSESFVEVSPTVQSSSVEVLELSERKR-----DCLISGDL 324
            .|:|.::|.|..           ..|.:.....||....:.|.:.:|....:     :|  :.::
Mouse   251 AGVIFVIHSPKK-----------EPQFDGLGLSSPVGMHARVTIRQLKTVHQEYPWGEC--NPNI 302

  Fly   325 QLSN---YRQAACLLACQTEAIVKKCGCHPYLLPIVGNKFKECNLNDTF-CYSANYDNFK----- 380
            :|.|   |....||..|:...|.:.|||.|:|||  ||.. ||:|.:.: |.|...|:.:
Mouse   303 KLRNFITYSTYGCLKECKARHIQRLCGCLPFLLP--GNGV-ECDLLEYYNCVSPILDHIERKGLC 364

  Fly   381 --SVRCDQCLPNCYDVTY-STLSYKTDLNQHKYSVSRFYSPELLNNDSFV------LRVYLAKQV 436
              ......|..:|.:..| :|:||.|..:|.   .:||.:.:|..:..::      :.:..:...
Mouse   365 TMGTHNSSCPVSCEETEYPATVSYSTFPSQR---ATRFLAKKLNQSQEYIRENLVNIEINYSDLN 426

  Fly   437 VPVIRKVTVMSWIGLLSDLGGIFNLCLGLSMISVVEF-------FYYCT--YRLYINYQLQKVQQ 492
            ..:.::...:|...||:|:||...|..|.|:|:::|.       ||:..  :.|.|...:|:...
Mouse   427 YKITQQQKAVSVPELLADVGGQLGLFCGASLITIIEIIEYFFTNFYWVLIFFLLKILETIQRTSP 491

  Fly   493 PR 494
            |:
Mouse   492 PQ 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk6	NP_611461.3	ASC	85..476	CDD:279230	97/452 (21%)
Asic5	NP_067345.1	ASC	41..466	CDD:366339	108/492 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820