DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk6 and ASIC4

DIOPT Version :9

Sequence 1:	NP_611461.3	Gene:	ppk6 / 37286	FlyBaseID:	FBgn0034489	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	NP_061144.4	Gene:	ASIC4 / 55515	HGNCID:	21263	Length:	539	Species:	Homo sapiens

Alignment Length:	506	Identity:	108/506 - (21%)
Similarity:	184/506 - (36%)	Gaps:	112/506 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 RKRGKDPSLIRTAI-------LATFWEYTERTKVSGMWLMRRNRTYGLSRFIWSSVLLQLLLLSI 78
            ::.|.:.||:....       ||||   ...:.:.|:........:||.|.:|:..||..|...:
Human    21 KEAGDEQSLLGAVAPGAAPRDLATF---ASTSTLHGLGRACGPGPHGLRRTLWALALLTSLAAFL 82

  Fly    79 YLTLLLWLKFYSYPILNTISNDLSITDVAFPGVTICSPKVVNSERVDRYVKTLKIPKEYDMAEVI 143
            |....|...:.:.|.|..:..........||.||:|:        ::|:           ....:
Human    83 YQAAGLARGYLTRPHLVAMDPAAPAPVAGFPAVTLCN--------INRF-----------RHSAL 128

  Fly   144 AGFDFLNAFTDQSFEPPGHDSYRATDAVLRLNNVSIWEAAMAVSPGCFDYVKRC-FWGHTEFQCN 207
            :..|..:........|...|.:||  |.||.....:.:..........|.:|.| |.||   .|:
Human   129 SDADIFHLANLTGLPPKDRDGHRA--AGLRYPEPDMVDILNRTGHQLADMLKSCNFSGH---HCS 188

  Fly   208 QSHEYLSFIPTTAYLGPCCSFNYNPRNASFVPFSANIFGMDGGLTF-----------VGAEGSER 261
            .|:..:.:   |.| |.|.:||.:||  |.:|..|.  ||..||..           :..|.:|.
Human   189 ASNFSVVY---TRY-GKCYTFNADPR--SSLPSRAG--GMGSGLEIMLDIQQEEYLPIWRETNET 245

  Fly   262 NLNTGLIVLVHHPMD--YVTEAAASVTITAQSESFVEVSPTVQSSSVEVLELSERKRDCLISGDL 324
            :...|:.|.:|...:  |:.:....|:...|:        .|......:..|.:...:|....:|
Human   246 SFEAGIRVQIHSQEEPPYIHQLGFGVSPGFQT--------FVSCQEQRLTYLPQPWGNCRAESEL 302

  Fly   325 Q------LSNYRQAACLLACQTEAIVKKCGCHPYLLPIVGNKFKECNLNDTFCYSANYDNFKSVR 383
            :      .|.|..:||.|.|:.||::::|.|....:|  |        |:|.|....|     :.
Human   303 REPELQGYSAYSVSACRLRCEKEAVLQRCHCRMVHMP--G--------NETICPPNIY-----IE 352

  Fly   384 C-DQCLPN--------CYDVTYSTLS-YKTDLNQ-------------HKYSVSRFYSPELLNNDS 425
            | |..|.:        |:..|...|: |..:::.             .||:.:..|    :..:.
Human   353 CADHTLDSLGGGPEGPCFCPTPCNLTRYGKEISMVRIPNRGSARYLARKYNRNETY----IRENF 413

  Fly   426 FVLRVYLAKQVVPVIRKVTVMSWIGLLSDLGGIFNLCLGLSMISVVEFFYY 476
            .||.|:........:.:........||.||||...|.:|.|:::::|...|
Human   414 LVLDVFFEALTSEAMEQRAAYGLSALLGDLGGQMGLFIGASILTLLEILDY 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk6	NP_611461.3	ASC	85..476	CDD:279230	90/433 (21%)
ASIC4	NP_061144.4	ASC	40..488	CDD:413546	105/487 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152124
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.850