Protein Alignment ppk6 and ASIC1

DIOPT Version :10

• Sequence 1: NP_611461.3
• Gene: ppk6 / 37286
• FlyBaseID: FBgn0034489
• Length: 498
• Species: Drosophila melanogaster
• Sequence 2: NP_064423.2
• Gene: ASIC1 / 41
• HGNCID: 100
• Length: 574
• Species: Homo sapiens
• Alignment Length: 521
• Identity: 101/521 - (19%)
• Similarity: 171/521 - (32%)
• Gaps: 164/521 - (31%)

  Fly    61 LSRFIWSSVLL-QLLLLSIYLTLLLWLKFYSYPILNTISNDLSITDVAFPGVTICSPKVVNSERV 124
            |.|.:|:...| .|.:|....|..:...|:.:.:  |..::::.:.:.||.||:|:   :|..|.
Human    41 LKRALWALCFLGSLAVLLCVCTERVQYYFHYHHV--TKLDEVAASQLTFPAVTLCN---LNEFRF 100

  Fly   125 DRYVKTLKIPKEYDMAEVIAGFDFLNAFTDQSFEPPGHDSYRATDAVLRLNN-VSIWEAAMA--- 185
            .:..|                                :|.|.|.:.:..||| ..|.:..||
Human   101 SQVSK--------------------------------NDLYHAGELLALLNNRYEIPDTQMADEK 133

  Fly   186 -----VSPGCFDYVKRCFWGHTEFQCNQSHEYLSFIPTTAYLGPCCS--------------FNYN 231
                 .....|...|...:...||.....|:....:.:..:.|..||              :.:|
Human   134 QLEILQDKANFRSFKPKPFNMREFYDRAGHDIRDMLLSCHFRGEVCSAEDFKVVFTRYGKCYTFN 198

  Fly   232 PRNASFVPFSANIFGMDGGLTFVGAEGSERNLNTGLIVLVHHPMD-YVT----------EAAASV 285
            .             |.||.......:|...|   ||.:::....| |:.          ||...|
Human   199 S-------------GRDGRPRLKTMKGGTGN---GLEIMLDIQQDEYLPVWGETDETSFEAGIKV 247

  Fly   286 TITAQSE-SFVE-----VSPTVQS----SSVEVLELSERKRDC---LISGDLQ-LSNYRQAACLL 336
            .|.:|.| .|::     |:|..|:    ....::.|......|   .:..||. ..:|...||.:
Human   248 QIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGTCKAVTMDSDLDFFDSYSITACRI 312

  Fly   337 ACQTEAIVKKCGCH--------PYLLPIVGNKFKEC---------NLNDTFCY------------ 372
            .|:|..:|:.|.|.        ||..|   .::|||         ..:..:|.
Human   313 DCETRYLVENCNCRMVHMPGDAPYCTP---EQYKECADPALDFLVEKDQEYCVCEMPCNLTRYGK 374

  Fly   373 -----------SANYDNFKSVRCDQCLPN---CYDVTYSTLSYKTDLNQHKYSVSRFYSPELLNN 423
                       ||.|...|..:.:|.:..   ..|:.:..|:|:|...:..|.::......|:..
Human   375 ELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGELLMTP 439

  Fly   424 DSFVLRVYLAKQVVPVIRKV--TVMSWIG-----------LLSDLGGIFNLCLGLSMISVVEFFY 475
            ..|...   ...|.|...|.  :::|..|           .|.|:||...|.:|.|:::|:|.|.
Human   440 VPFSCH---GHGVAPYHPKAGCSLLSHEGPPPQRPFPKPCCLGDIGGQMGLFIGASILTVLELFD 501

  Fly   476 Y 476
            |
Human   502 Y 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk6	NP_611461.3	ASC	85..476	CDD:459966	93/494 (19%)
ASIC1	NP_064423.2	ENaC	19..556	CDD:273304	101/521 (19%)