Protein Alignment ppk6 and asic1b

DIOPT Version :10

• Sequence 1: NP_611461.3
• Gene: ppk6 / 37286
• FlyBaseID: FBgn0034489
• Length: 498
• Species: Drosophila melanogaster
• Sequence 2: NP_999956.1
• Gene: asic1b / 407672
• ZFINID: ZDB-GENE-040513-1
• Length: 557
• Species: Danio rerio
• Alignment Length: 564
• Identity: 115/564 - (20%)
• Similarity: 195/564 - (34%)
• Gaps: 183/564 - (32%)

  Fly     3 ESGKWPTPGKKNSKGDGSR-KRGKDPSLIRTAILATFWEYTERTKVSGMWLMRRN------RTYG 60
            |.||:...|......||.. :...|.|      ||||:        .|..|...|      :.:.
Zfish    39 EQGKYQEEGDDPDAYDGPEDEEAPDIS------LATFF--------GGCSLHGANHVFVEDKKFS 89

  Fly    61 LSRFIWSSVLL---QLLLLSIYLTLLLWLKFYSYPILNTISNDLSITDVAFPGVTICSPKVVNSE 122
            :.:.:|:.|.|   .:.||.:...::.:|: |.|.   |:.::.:..::.||.:|:|:.......
Zfish    90 IRQGLWALVFLLAISMFLLQVVDRVIYYLQ-YDYV---TLLDERNAKNMTFPAITLCNYNTFRRS 150

  Fly   123 RV---------------DRYVKTLKIPKE-------YDMAEVIAGFDFLNAFTDQSFEPPGHDSY 165
            ::               |.....:.:..|       :.:||      |.|           ...:
Zfish   151 QLSYSDLLFMGPLLGYEDNMAPGIPLAPEPDRQGSRFSLAE------FFN-----------RTRH 198

  Fly   166 RATDAVLRLNNVSIWEAAMAVSPGCFDYVKRCFWGHTEFQCNQSHEYLSFIPTTAYLGPCCSFNY 230
            |..|.:|..|                      |.|.   :|...|....|   |.| |.|.:||
Zfish   199 RMDDMLLECN----------------------FAGK---ECGAEHWREIF---TRY-GKCYTFN- 233

  Fly   231 NPRNASFVPFSANIFGMDGGLTFVGAEGSERNLNTGLIVLVHHPMD-YVT----------EAAAS 284
                          .|.||....:..:|   .:..||.:::....| |:.          ||...
Zfish   234 --------------SGQDGRPLLITTKG---GMGNGLEIMLDIQQDEYLPVWGETDETTFEAGIK 281

  Fly   285 VTITAQSE-SFVE-----VSPTVQSSSVEVLELSERK--------RDCL---ISGDLQLSNYRQA 332
            |.|..|.| .|::     |:|..|:    .:...|::        .||.   |..|. .:.|...
Zfish   282 VQIHTQDEPPFIDQLGFGVAPGFQT----FVSCQEQRLTYLPPPWGDCKATPIDSDF-FNTYSIT 341

  Fly   333 ACLLACQTEAIVKKCGCH--------PYLLPIVGNKFKECNLNDTFCYSANYDNFKSVRCDQCLP 389
            ||.:.|:|..:|:.|.|.        ||..|   .::||| .:....:....||      |.|:
Zfish   342 ACRIDCETRYLVENCNCRMVHMPGDAPYCTP---EQYKEC-ADPALDFLVERDN------DYCV- 395

  Fly   390 NCYDVTYSTLSYKTDLN--------QHKYSVSRFYSPE-LLNNDSFVLRVYLAKQVVPVIRKVTV 445
             | :...:...|..:|:        ..||...::...| .::::..||.::........|.:...
Zfish   396 -C-ETPCNMTRYGKELSFVRIPSKASAKYLAKKYNKTEQYISDNIMVLDIFFEALNYETIEQKKA 458

  Fly   446 MSWIGLLSDLGGIFNLCLGLSMISVVEFFYYCTYRLY--INYQL 487
            ....|||.|:||...|.:|.|:::::|.|.|    ||  |.::|
Zfish   459 YELAGLLGDIGGQMGLFIGASILTILELFDY----LYEVIKFKL 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk6	NP_611461.3	ASC	85..476	CDD:459966	90/457 (20%)
asic1b	NP_999956.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	36..57		6/17 (35%)
		ENaC	66..548	CDD:273304	107/531 (20%)
		GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:Q1XA76	477..479		1/1 (100%)