DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk6 and asic1c

DIOPT Version :9

Sequence 1:	NP_611461.3	Gene:	ppk6 / 37286	FlyBaseID:	FBgn0034489	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	XP_021325802.1	Gene:	asic1c / 407670	ZFINID:	ZDB-GENE-040513-3	Length:	562	Species:	Danio rerio

Alignment Length:	507	Identity:	115/507 - (22%)
Similarity:	182/507 - (35%)	Gaps:	144/507 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 RTKVSGM---WLMRRNRTYGLSRFIWSSVLLQLLLLSIYLTLLL---W---LKFYSYPILNTI-- 97
            ||||.|:   :...:::|   .|..|      ||.|.:.|.||.   |   |...|||.:..|
Zfish    44 RTKVHGLKHAFSPHKSKT---QRLFW------LLALLVCLGLLFTWSWNRILYLLSYPAVTKIYM 99

  Fly    98 --SNDLSITDVAFPGVTICSP---KVVNSERVDRY-------------------VKTLKIPKEYD 138
              ||:::     ||.:|.|:.   :|.:..|.|.|                   |..||..:..:
Zfish   100 VWSNNMT-----FPAITFCNQNRLRVSSLTRDDLYYSGYWMDILHLNHTLNRQSVSMLKHSRHRE 159

  Fly   139 MAEVIAGFDFLNAFTDQSFEPPGHDSYRATDAVLRLNNVSIWEAAMAVSPGCFDYVKRC-FWGHT 202
              .::...||      ..:.||...|...|:.:.||.:            ...|.:..| |.|.
Zfish   160 --RLLHLLDF------SHYSPPPDQSLNTTEMIDRLGH------------QLQDMLLECRFRGE- 203

  Fly   203 EFQCNQSHEYLSFIPTTAYLGPCCSFNYNPRNASFVPFSANIFGMDGGLTFVGAEGSERNLNTGL 267
              .|.    |.:|.|.....|.|.:||               .|:||.......:|...|   ||
Zfish   204 --NCT----YKNFTPIYTRYGKCYTFN---------------SGLDGNPLLTTLKGGTGN---GL 244

  Fly   268 IVLVHHPMD-YVT----------EAAASVTITAQSE-SFVE-----VSPTVQS----SSVEVLEL 311
            .:::....| |:.          ||...|.|.:|.| .|::     |:|..|:    ....:|.|
Zfish   245 EIMLDIQQDEYLPVWGDTDETSYEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVSCQQQLLLYL 309

  Fly   312 SERKRDCLISGDLQ---LSNYRQAACLLACQTEAIVKKCGCHPYLLP-----IVGNKFKECNLND 368
            .....||. |..:.   .|.|...||.:.|:|..:::.|.|....:|     ....::|:| .:.
Zfish   310 PPPWGDCR-SAPMDSEYFSTYSITACRIDCETRYLLENCNCRMVHMPGTSTVCTPEQYKDC-ADP 372

  Fly   369 TFCYSANYDNFKSVRCDQCLPNCYDVTYSTLSYKTDLN--------QHKYSVSRFYSPE-LLNND 424
            ...:....||      |.|:  | |...:...|..:|:        ..||...:|...| .:.::
Zfish   373 ALDFLVEKDN------DYCV--C-DTPCNMTRYGKELSMVKIPSKASAKYLAKKFNKTEQYITDN 428

  Fly   425 SFVLRVYLAKQVVPVIRKVTVMSWIGLLSDLGGIFNLCLGLSMISVVEFFYY 476
            ..||.::........|.:.......|||.|:||...|.:|.|:::::|.|.|
Zfish   429 ILVLDIFFEALNYEKIEQKKAYEVAGLLGDIGGQMGLFIGASVLTILEIFDY 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk6	NP_611461.3	ASC	85..476	CDD:279230	100/458 (22%)
asic1c	XP_021325802.1	ASC	34..531	CDD:322155	115/507 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586600
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.950