Protein Alignment ppk6 and asic4b

DIOPT Version :10

• Sequence 1: NP_611461.3
• Gene: ppk6 / 37286
• FlyBaseID: FBgn0034489
• Length: 498
• Species: Drosophila melanogaster
• Sequence 2: NP_999951.1
• Gene: asic4b / 407667
• ZFINID: ZDB-GENE-040513-6
• Length: 558
• Species: Danio rerio
• Alignment Length: 485
• Identity: 96/485 - (19%)
• Similarity: 173/485 - (35%)
• Gaps: 119/485 - (24%)

  Fly    60 GLSRFIWSSVLLQLLLLSIYLTLLLWLKFYSYPILNTISNDLSITDVAFPGVTICSPKVVNSERV 124
            |..:.:|...||..|.|.:|........:...|.|..:..: :..::.||.:|:|:        |
Zfish    67 GFRQTLWGLALLVSLGLFLYQATWSAATYLERPHLAALREE-TRRELTFPAITLCN--------V 122

  Fly   125 DRY-VKTLKIPKEYDMAEVIAGFDFLNAFTDQS----------FEPPGH-DSYRATDAVLRLNNV 177
            :|: ...|.....|.:|.       |.....:|          :.||.. |.::.|...|.
Zfish   123 NRFRFSALTDADIYHLAN-------LTGLPPKSRKGHRPSELQYPPPNMLDIFQRTGHQLE---- 176

  Fly   178 SIWEAAMAVSPGCFDYVKRC-FWGHTEFQCNQSHEYLSFIPTTAYLGPCCSFNYNPRNASFVPFS 241
                          |.:|.| |.|.     |.|.|..|.:.|.  .|.|.:||.|..:    |..
Zfish   177 --------------DMLKSCNFSGQ-----NCSSEDFSVVYTR--YGKCYTFNGNKTS----PKR 216

  Fly   242 ANIFGMDGGLTF-----------VGAEGSERNLNTGLIVLVHHPMD--YVTEAAASVTITAQSES 293
            ....|...||..           :..|.:|..|..|:.|.:|...:  |:.:....|:...|:
Zfish   217 VRQGGTGNGLEMMLDIQQDEYLPIWRETNETTLEAGIRVQIHSQNEPPYIHQLGFGVSPGFQT-- 279

  Fly   294 FVEVSPTVQSSSVEVLELSERKRDCLISGDLQL---SNYRQAACLLACQTEAIVKKCGCHPYLLP 355
                  .|......:..|.:...:|..|.:..:   ..|..:||.|.|::..:.::|.|....:|
Zfish   280 ------FVSCQEQRLTYLPQPWGNCRASSEPVIPGYDTYSVSACRLHCESTQVQRECNCRMVHMP 338

  Fly   356 IVGNKFKECNLNDTFCYSANYDNFKSVRC-DQCLPNCYDVTYSTLSYKTDLNQHKYS-------- 411
              |:.        ..|..:      .::| |:.|.:....|..:...:|..|..:|.
Zfish   339 --GDA--------DICAPS------KIKCVDKALASLQKSTGDSCPCETPCNLTRYGKELSMVKI 387

  Fly   412 --------VSRFY--SPELLNNDSFVLRVYLAKQVVPVIRKVTVMSWIGLLSDLGGIFNLCLGLS 466
                    :||.|  |.|.:.::..:|.::........|.:.......|||.|:||...|.:|.|
Zfish   388 PSRGSARYLSRKYQKSEEYIRDNFLILDIFFEALNYETIEQKKAYDIAGLLGDIGGQMGLFIGAS 452

  Fly   467 MISVVEFFYYCTYRLYINYQLQKVQQPRKA 496
            :::::|...| .|.:..| :::::.:|:|:
Zfish   453 ILTILEILDY-IYEVAKN-KIKQLLKPKKS 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk6	NP_611461.3	ASC	85..476	CDD:459966	84/438 (19%)
asic4b	NP_999951.1	ENaC	54..497	CDD:273304	96/485 (20%)
		GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:P78348	450..452		1/1 (100%)