DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk6 and Scnn1a

DIOPT Version :9

Sequence 1:	NP_611461.3	Gene:	ppk6 / 37286	FlyBaseID:	FBgn0034489	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	NP_113736.1	Gene:	Scnn1a / 25122	RGDID:	3639	Length:	699	Species:	Rattus norvegicus

Alignment Length:	593	Identity:	124/593 - (20%)
Similarity:	219/593 - (36%)	Gaps:	164/593 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 PTPGKKNSKGDGSRKRG--------KDPSLIRTAILATFWEYTE-------RTKVSG---MWLMR 54
            |.|.:...|||...::|        :.|:....|::.....|.|       .|.:.|   :...:
  Rat    40 PQPMQGLGKGDKREEQGLGPEPSAPRQPTEEEEALIEFHRSYRELFQFFCNNTTIHGAIRLVCSK 104

  Fly    55 RNRTYGLSRFIWSSVLLQLLLLSIYLTLLLWLKFYSYPILNTISNDLSITDVAFPGVTICSPKVV 119
            .||   :....|:.:.|....:..:...||:.::.|||:  :::.:|:...:.||.||:|:   :
  Rat   105 HNR---MKTAFWAVLWLCTFGMMYWQFALLFEEYLSYPV--SLNINLNSDKLVFPAVTVCT---L 161

  Fly   120 NS----------ERVDRYV-KTLKIPKEYDMAEVIAGF------------DFLNAFTDQ----SF 157
            |.          |.:||.. :||     :|:.:..:.:            |.|.||...    ..
  Rat   162 NPYRYTEIKEELEELDRITEQTL-----FDLYKYNSSYTRQAGARRRSSRDLLGAFPHPLQRLRT 221

  Fly   158 EPPGHD--SYRATDAVLRLNNVSI----WEAAMAV----SPGCF--------DYVKRCFWGHTEF 204
            .||.:.  :.|:..:.:|.||..:    |:....:    ...||        |.|:..:..|
  Rat   222 PPPPYSGRTARSGSSSVRDNNPQVDRKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFH--- 283

  Fly   205 QCNQSHEYLSFIPTTAYLGPC------------CSFNYNPRN-ASFVPFSANIFGMDGGLTFVGA 256
                   |::.:...:...|.            |.||..|.| |::..|...::|  ...||...
  Rat   284 -------YINILSRLSDTSPALEEEALGNFIFTCRFNQAPCNQANYSKFHHPMYG--NCYTFNDK 339

  Fly   257 EGSE------RNLNTGL-IVLVHHPMDYV----TEAAASVTITAQSE-SFVE-----VSPTVQSS 304
            ..|.      ..:|.|| :.|.....|::    |...|.|.:..|.| :|::     :.|.|::|
  Rat   340 NNSNLWMSSMPGVNNGLSLTLRTEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETS 404

  Fly   305 SVEVLELSERKR----------DCLISG------DLQLSNYRQAACLLACQTEAIVKKCGCHPYL 353
                  :|.||.          ||..:|      :|..|.|.|..|:.:|..|.::|||||....
  Rat   405 ------ISMRKEALDSLGGNYGDCTENGSDVPVKNLYPSKYTQQVCIHSCFQENMIKKCGCAYIF 463

  Fly   354 LP-IVGNKFKECNLNDT--FCYSANYDNFK--SVRC-DQCLPNCYDVTYSTLSYKTDLNQHKY-- 410
            .| ..|.:|.:.....:  :||......|.  |:.| .:|...|     |.::||......::
  Rat   464 YPKPKGVEFCDYRKQSSWGYCYYKLQGAFSLDSLGCFSKCRKPC-----SVINYKLSAGYSRWPS 523

  Fly   411 -----------SVSRFYSPELLNNDSFVLRVYLAKQVVPVIRKVTVMSWIGLLSDLGGIFNLCLG 464
                       |:...|:.....|....|.::..:.......:...::.:.|||:||..::|..|
  Rat   524 VKSQDWIFEMLSLQNNYTINNKRNGVAKLNIFFKELNYKTNSESPSVTMVSLLSNLGSQWSLWFG 588

  Fly   465 LSMISVVE 472
            .|::||||
  Rat   589 SSVLSVVE 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk6	NP_611461.3	ASC	85..476	CDD:279230	106/498 (21%)
Scnn1a	NP_113736.1	ENaC	80..677	CDD:273304	116/553 (21%)
Scnn1a	NP_113736.1	deg-1	88..600	CDD:273309	114/545 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345629
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.750