DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk6 and Scnn1g

DIOPT Version :9

Sequence 1:	NP_611461.3	Gene:	ppk6 / 37286	FlyBaseID:	FBgn0034489	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	NP_058742.2	Gene:	Scnn1g / 24768	RGDID:	3641	Length:	650	Species:	Rattus norvegicus

Alignment Length:	583	Identity:	120/583 - (20%)
Similarity:	199/583 - (34%)	Gaps:	176/583 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 WLMRRNRTYG----------LSRFIWSSVLLQLLLLSIYLTLLLWLKFYSYPILNTISNDLSITD 105
            |......|:|          |.|.:|.:..|..:.|.|:...||...||:.    ::|..:....
  Rat    31 WYCMNTNTHGCRRIVVSRGRLRRLLWIAFTLTAVALIIWQCALLVFSFYTV----SVSIKVHFQK 91

  Fly   106 VAFPGVTICSPKVVNSER----------VDRYVKTLKI-------------------------PK 135
            :.||.||||:   :|..:          :|...|...:                         |:
  Rat    92 LDFPAVTICN---INPYKYSAVSDLLTDLDSETKQALLSLYGVKESRKRREAGSMPSTLEGTPPR 153

  Fly   136 EYDMAEVIA--------GFDFLNAFTDQSFEPPGHDSYRATDAV--------------------- 171
            .:.:..::.        ..||   ||.:..:..|...::|::.:
  Rat   154 FFKLIPLLVFNENEKGKARDF---FTGRKRKISGKIIHKASNVMHVHESKKLVGFQLCSNDTSDC 215

  Fly   172 ------LRLNNVSIW--------------EAAMAVSPGCFDYVKRCFWGHTEFQCNQSHEYLSFI 216
                  ..:|.:..|              |..:.:|....:.:..||:  ....|:..:..|...
  Rat   216 ATYTFSSGINAIQEWYKLHYMNIMAQVPLEKKINMSYSAKELLVTCFF--DGMSCDARNFTLFHH 278

  Fly   217 PTTAYLGPCCSFNYNPRNASFVPFSANIFGMDGGLTFVGAEGSERNLNTGLIVLVHHPMDY---- 277
            |   ..|.|.:|| |..||:.:..|..              |||..|.   ::|..:..:|
  Rat   279 P---MYGNCYTFN-NKENATILSTSMG--------------GSEYGLQ---VILYINEDEYNPFL 322

  Fly   278 VTEAAASVTITAQSE-SFVE----VSPTVQSSSV-----EVLELSERKRDCLISG-DLQLSNYRQ 331
            |:...|.|.|..|:| .|:|    ...|..|:|:     |..:|||....|...| |:.::|...
  Rat   323 VSSTGAKVLIHQQNEYPFIEDVGMEIETAMSTSIGMHLTESFKLSEPYSQCTEDGSDVPVTNIYN 387

  Fly   332 AA-----CLLACQTEAIVKKCGCHPYL--LPIVGNKFKECNL----NDTFCYSANYDNF--KSVR 383
            ||     ||.:|....:|:||||..|.  ||...|   .||.    |..:||...|..|  :.:.
  Rat   388 AAYSLQICLYSCFQTKMVEKCGCAQYSQPLPPAAN---YCNYQQHPNWMYCYYQLYQAFVREELG 449

  Fly   384 CDQ-CLPNC----YDVTYSTLSYKTD------LNQHKYSVSRFYSPELLNNDSFVLRVYLAKQVV 437
            |.. |..:|    :.:|.|...:.::      ||...:..|:..:.:|...|...|.::......
  Rat   450 CQSVCKQSCSFKEWTLTTSLAQWPSEASEKWLLNVLTWDQSQQINKKLNKTDLAKLLIFYKDLNQ 514

  Fly   438 PVIRKVTVMSWIGLLSDLGGIFNL---CLGLSMISVVEFFYYCTYRLYINYQLQKVQQPRKAW 497
            ..|.:....|...|||:.||...|   |..:.:|.::|.|:...:.:....|..|.    |.|
  Rat   515 RSIMESPANSIEMLLSNFGGQLGLWMSCSVVCVIEIIEVFFIDFFSIIARRQWHKA----KDW 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk6	NP_611461.3	ASC	85..476	CDD:279230	105/516 (20%)
Scnn1g	NP_058742.2	ENaC	24..631	CDD:273304	120/583 (21%)
Scnn1g	NP_058742.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	577..628
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345625
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.750