DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk6 and Scnn1b

DIOPT Version :9

Sequence 1:	NP_611461.3	Gene:	ppk6 / 37286	FlyBaseID:	FBgn0034489	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	NP_036780.1	Gene:	Scnn1b / 24767	RGDID:	3640	Length:	638	Species:	Rattus norvegicus

Alignment Length:	546	Identity:	111/546 - (20%)
Similarity:	186/546 - (34%)	Gaps:	156/546 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 MWLMRRNRTYGLSRFI---------WSSVLLQLLLLSIYLTLLLW------LKFYSYPILNTISN 99
            :|......|:|..|.|         |      .||..::..|:.|      ..:.|:.:  ::|.
  Rat    27 VWYCNNTNTHGPKRIICEGPKKKAMW------FLLTLLFACLVCWQWGVFIQTYLSWEV--SVSL 83

  Fly   100 DLSITDVAFPGVTICSPKVVNSERVDRYVKTLKIPKEYDMAEVIAGFDFLNAFTDQSFEPPGHDS 164
            .:....:.||.||:|:.......:|...:|.|              :..:.|..|:...|  ..|
  Rat    84 SMGFKTMNFPAVTVCNSSPFQYSKVKHLLKDL--------------YKLMEAVLDKILAP--KSS 132

  Fly   165 YRATDAVLRLNNVSIWEAAMAV--------------------------------SPGCFDYVKRC 197
            :..|.:.|   |.:||.....|                                :.||...::.|
  Rat   133 HTNTTSTL---NFTIWNHTPLVLIDERNPDHPVVLNLFGDSHNSSNPAPGSTCNAQGCKVAMRLC 194

  Fly   198 ---------------FWGHTEFQCNQSHEYLS-----------FIPTTAYLG------PCCSFNY 230
                           ....||:...|:....|           :.|....|.      ||...|:
  Rat   195 SANGTVCTFRNFTSATQAVTEWYILQATNIFSQVLPQDLVGMGYAPDRIILACLFGTEPCSHRNF 259

  Fly   231 NPRNASFVPFSANIFGMDGGLTFVGAEGSERNLNTGL-IVLVHHPMDYV----TEAAASVTITAQ 290
            .|   .|.|...|.:..:.|:|......:......|| ::|.....|||    :.|.|.:.:..|
  Rat   260 TP---IFYPDYGNCYIFNWGMTEKALPSANPGTEFGLKLILDIGQEDYVPFLASTAGARLMLHEQ 321

  Fly   291 -------SESFVEVSPTVQSSSVEVLEL---SERKRDCLISG-DLQLSN--------YRQAACLL 336
                   .|....::.|..|..|.:.:|   .|....|.::| |:.:.|        |...|||.
  Rat   322 RTYPFIREEGIYAMAGTETSIGVLLDKLQGKGEPYSPCTMNGSDVAIQNLYSDYNTTYSIQACLH 386

  Fly   337 ACQTEAIVKKCGCHPYLLPI-VGNKFKECNLND----TFCYSANYDNFKSVRCDQCLPNC----- 391
            :|..:.::..|.|..||.|: .|.|:  ||..|    .:||.:.  ....|:.:.||..|
  Rat   387 SCFQDHMIHNCSCGHYLYPLPAGEKY--CNNRDFPDWAYCYLSL--QMSVVQRETCLSMCKESCN 447

  Fly   392 ---YDVTYSTLSYKTDLNQ----HKYSVSRFYSPEL-LNNDSFV-LRVYLAKQVVPVIRKVTVMS 447
               |.:|.|...:.::.::    |..|..|..|..: |:....| |.:|..:.....|.:....:
  Rat   448 DTQYKMTISMADWPSEASEDWILHVLSQERDQSSNITLSRKGIVKLNIYFQEFNYRTIEESPANN 512

  Fly   448 WIGLLSDLGGIFNLCLGLSMISVVEF 473
            .:.|||:|||.|...:|.|::.::||
  Rat   513 IVWLLSNLGGQFGFWMGGSVLCLIEF 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk6	NP_611461.3	ASC	85..476	CDD:279230	102/502 (20%)
Scnn1b	NP_036780.1	ENaC	21..621	CDD:273304	111/546 (20%)
		deg-1	29..538	CDD:273309	108/542 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	598..620
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345619
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.750