DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk6 and asic-1

DIOPT Version :9

Sequence 1:	NP_611461.3	Gene:	ppk6 / 37286	FlyBaseID:	FBgn0034489	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	NP_491214.3	Gene:	asic-1 / 191422	WormBaseID:	WBGene00022815	Length:	823	Species:	Caenorhabditis elegans

Alignment Length:	446	Identity:	101/446 - (22%)
Similarity:	167/446 - (37%)	Gaps:	103/446 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 SNDLSITD--VAF----PGVTICSPKVVNSERVDRYVKTLKIPKEYDMAEVIAGFDFLNAFTDQS 156
            :||.|:.|  |.|    |..|: ||.|...|             |.|.|....|.....|...::
Worm   414 TNDTSLDDRVVKFWDIQPSTTM-SPIVKKKE-------------ERDKAYGYTGVKDRIALRAKA 464

  Fly   157 FEPPGHDSYRATDAVLRLNNVSIWEAAMAVSPGCFDYVKRCFWGHTEFQCNQSHEYLSFIPTTAY 221
            .|    :...|.||   |.....|:    :|....|::.:|.:...|  ||..|:::.::..|
Worm   465 ME----NMIFAVDA---LTEEEKWK----ISYNKSDFIMKCSFNGRE--CNVKHDFVEYLDPT-- 514

  Fly   222 LGPCCSFNYNPRNASFVPFSANIFGMDGGLTFVGAEGSERN---LNTGLIVLVHHPMDYVTEAAA 283
            .|.|  |.|..:                    :|...:||:   ....|.|.|:......|..||
Worm   515 YGAC--FTYGQK--------------------LGNNTNERSGPAYGLRLEVFVNVTEYLPTTEAA 557

  Fly   284 SVTITAQS---ESFVEV----SPT--VQSSSVE---VLELSERKRDCLISGDLQLSNYRQAA--- 333
            .|.:|..:   :.|.:.    :||  |.|..::   ::.|.....||:..|..:...|.|.|
Worm   558 GVRLTVHATDEQPFPDTLGFSAPTGFVSSFGIKLKSMVRLPAPYGDCVREGKTEDFIYTQKAYNT 622

  Fly   334 --CLLACQTEAIVKKCGC-----HPYLLPIVGNKFKECNLNDTF---C-----YSANYDNFK-SV 382
              |..:|..:.:.|.|||     .||      .:.|.|.::|.:   |     :.|..|:.| ..
Worm   623 EGCQRSCIQKHLSKTCGCGDPRFPPY------RESKNCPVDDPYKRECIKNEMHVATRDSKKLGC 681

  Fly   383 RCDQ-CLPNCYDVTYSTLSYKT---DLNQHKYSVSRFYSPELLNNDSFVLRVYLAKQVVPVIRKV 443
            .|.| |..:.|.|:||...:..   ||:.....::..:..........::.||..:.....:.:.
Worm   682 SCKQPCNQDVYSVSYSASRWPAIAGDLSGCPLGMAAHHCLNYKREQGSMIEVYFEQLNYESLLES 746

  Fly   444 TVMSWIGLLSDLGGIFNLCLGLSMISV--VEFFYYCTYRLYINYQLQKVQQPRKAW 497
            ....|..||||.||...|.:|:|:|::  |..|::..:...|:....|.:..||::
Worm   747 EAYGWSNLLSDFGGQLGLWMGVSVITIGEVACFFFEVFISLISSNRTKRRPARKSF 802

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk6	NP_611461.3	ASC	85..476	CDD:279230	97/423 (23%)
asic-1	NP_491214.3	deg-1	16..779	CDD:273309	96/421 (23%)
		ASC	17..>104	CDD:279230
		ASC	<469..788	CDD:295594	79/357 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820