Protein Alignment Hacl and PDC6

DIOPT Version :9

• Sequence 1: NP_611460.1
• Gene: Hacl / 37285
• FlyBaseID: FBgn0034488
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: NP_011601.3
• Gene: PDC6 / 852978
• SGDID: S000003319
• Length: 563
• Species: Saccharomyces cerevisiae
• Alignment Length: 568
• Identity: 120/568 - (21%)
• Similarity: 216/568 - (38%)
• Gaps: 109/568 - (19%)

  Fly     1 MAEVEAVQIIAESLKQQGVEYVFGIIG-IPVIELSMAFQAAGLKYIGMRNEQAACYAAQAIGYLT 64
            |:|:...:.:.|.|||..|..:||:.| ..:..|...::..||::.|..||..|.|||.....:.
Yeast     1 MSEITLGKYLFERLKQVNVNTIFGLPGDFNLSLLDKIYEVDGLRWAGNANELNAAYAADGYARIK 65

  Fly    65 GKPGVCLVVSGPGLLHVTGGMANAQVNCWPLIVIGGATNQD--------HEGIGGFQECPQVELS 121
            |. .|.:...|.|.|....|:|.:......::.:.|..:..        |..:|.........:|
Yeast    66 GL-SVLVTTFGVGELSALNGIAGSYAEHVGVLHVVGVPSISAQAKQLLLHHTLGNGDFTVFHRMS 129

  Fly   122 RPYCKYAARPATAALIPLHVEKAVRYATYGRPGVAYLDFPGNILQSKAQEASIYKALAHPAPPLA 186
            ....:..:.....|..|..:::.:| .|:.....:||..|.|::..|...:.:.|.:     .|:
Yeast   130 ANISETTSMITDIATAPSEIDRLIR-TTFITQRPSYLGLPANLVDLKVPGSLLEKPI-----DLS 188

  Fly   187 YPPHD-----DVI-RAAKLLRQAKRPLVIVGKGSAYAHAENTLRHFIENTNLPFLPTPMGKGVVS 245
            ..|:|     :|| ...:|::.:|.|:::....::..:.:...:..|:.|..|...||:|||.:.
Yeast   189 LKPNDPEAEKEVIDTVLELIQNSKNPVILSDACASRHNVKKETQKLIDLTQFPAFVTPLGKGSID 253

  Fly   246 DTAP------------QCVSSARTLALQKADVVLLLGARLNWILHFGKAPRYDKDVKFIQVDINP 298
            :..|            |.|..    |::.||::|.:||.|:                    |.|.
Yeast   254 EQHPRYGGVYVGTLSKQDVKQ----AVESADLILSVGALLS--------------------DFNT 294

  Fly   299 EELHNSVVASVAIQADIRPFAEQLFEQMNA----VNFRFGYEQ---------DWWKQLAVKCKQN 350
            .....|......::     |.....:..||    |..:|..:.         ..:|.:.|..|
Yeast   295 GSFSYSYKTKNVVE-----FHSDYVKVKNATFLGVQMKFALQNLLKVIPDVVKGYKSVPVPTK-- 352

  Fly   351 RDTVQKMSLNTETPLNYYAVFHHLRELLPKDTIIVSEGANTMDIGRSMLLNEQPRHRLDAGTFGT 415
              |.....:...|||....:::.|.:.|.:..:|:|| ..|...|.:..:..:..:.:....:|:
Yeast   353 --TPANKGVPASTPLKQEWLWNELSKFLQEGDVIISE-TGTSAFGINQTIFPKDAYGISQVLWGS 414

  Fly   416 MGVGPGFAVAAALFCRDFAPGKRVLCVEGDSAFGFSGMEIETMVRYKLPVTIVIVNNNGIYGGFD 480
            :|...|..:.||....:..|.|||:...||.:...:..||.||:|:.|...:.::||:|.
Yeast   415 IGFTTGATLGAAFAAEEIDPNKRVILFIGDGSLQLTVQEISTMIRWGLKPYLFVLNNDGY----- 474

  Fly   481 KDTFEAIRSEGDLTQITPPSALGVQVRYEE--------MMKMFGMKGY 520
              |.|.:        |..|.|     .|.|        ::..||.|.|
Yeast   475 --TIEKL--------IHGPHA-----EYNEIQTWDHLALLPAFGAKKY 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hacl	NP_611460.1	PRK09259	8..552	CDD:236433	118/561 (21%)
		TPP_PYR_POX_like	8..161	CDD:132918	35/161 (22%)
		TPP_enzyme_M	195..322	CDD:278628	25/138 (18%)
		TPP_BZL_OCoD_HPCL	367..550	CDD:238962	38/162 (23%)
PDC6	NP_011601.3	PDC1	1..563	CDD:226470	120/568 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S956
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.860