Protein Alignment Hacl and ARO10

DIOPT Version :9

• Sequence 1: NP_611460.1
• Gene: Hacl / 37285
• FlyBaseID: FBgn0034488
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: NP_010668.3
• Gene: ARO10 / 851987
• SGDID: S000002788
• Length: 635
• Species: Saccharomyces cerevisiae
• Alignment Length: 637
• Identity: 136/637 - (21%)
• Similarity: 232/637 - (36%)
• Gaps: 158/637 - (24%)

  Fly    20 EYVF---------GIIGIP------VIE--LSMAFQAAGLKYIGMRNEQAACYAAQAIGYLTGKP 67
            ||:|         .:.|:|      ::|  .|.:.::|||:::|..||..|.|||......:.|.
Yeast    29 EYIFKRLLSIDTKSVFGVPGDFNLSLLEYLYSPSVESAGLRWVGTCNELNAAYAADGYSRYSNKI 93

  Fly    68 GVCLVVSGPGLLHVTGGMANA-QVNCWPLIVIGGATNQDHEGIGGFQE------CPQVELS---- 121
            |..:...|.|.|....|:|.: ..|...|.::|.|.:.|... ..|.:      .||:..|
Yeast    94 GCLITTYGVGELSALNGIAGSFAENVKVLHIVGVAKSIDSRS-SNFSDRNLHHLVPQLHDSNFKG 157

  Fly   122 ------------RPYCK--YAARPATAALIPLHVEKAVR-YATYGRPGVAYL--DFPG------- 162
                        |..|.  |.....||.   ..|:..:| ...|.:||..::  ||..
Yeast   158 PNHKVYHDMVKDRVACSVAYLEDIETAC---DQVDNVIRDIYKYSKPGYIFVPADFADMSVTCDN 219

  Fly   163 --NILQSKAQEASIYKALAHPAPPLAYPPHDDVIRAAKLLRQAKRPLVIVGKGSAYAHAENTLRH 225
              |:.:...|:..:|        |......|.:.:....:..:|.|.::....:......|.|..
Yeast   220 LVNVPRISQQDCIVY--------PSENQLSDIINKITSWIYSSKTPAILGDVLTDRYGVSNFLNK 276

  Fly   226 FIENTNLPFLPTPMGKGVVSDTAPQCVSSARTLA--------LQKADVVLLLGARLNWILHFGKA 282
            .|..|.:....|.|||.|:.::.|..:.......        .:..|:||..|..:|.|.:....
Yeast   277 LICKTGIWNFSTVMGKSVIDESNPTYMGQYNGKEGLKQVYEHFELCDLVLHFGVDINEINNGHYT 341

  Fly   283 PRYDKDVKFIQVDINPEELHNSVVASVAIQADIRPFAEQLFEQMN-AVNFRFGYEQDWWKQLAVK 346
            ..|..:.|.||       .|.:.:..|    |.|...||:|:.:| |...:..|::....:|:::
Yeast   342 FTYKPNAKIIQ-------FHPNYIRLV----DTRQGNEQMFKGINFAPILKELYKRIDVSKLSLQ 395

  Fly   347 CKQNRDTVQKMSLNTETPLNYYAVF---HHLRELLPK-----DTIIVSEGANTMDIGRSMLLNEQ 403
            ...|.......::..|.|.|..:..   .||::.:||     |.::...|:....: |......|
Yeast   396 YDSNVTQYTNETMRLEDPTNGQSSIITQVHLQKTMPKFLNPGDVVVCETGSFQFSV-RDFAFPSQ 459

  Fly   404 PRHRLDAGTFGTMG------VGPGFA--------VAAALFCRDFAPGKRVLCVEGDSAFGFSGME 454
            .:: :..|.|.::|      :|.|.|        :.......|:.|  |::..|||.|...:..|
Yeast   460 LKY-ISQGFFLSIGMALPAALGVGIAMQDHSNAHINGGNVKEDYKP--RLILFEGDGAAQMTIQE 521

  Fly   455 IETMVRYKLPVTIVIVNNNG---------------------------IYGGFD-KDTFEAIRSEG 491
            :.|:::..:|:.::|.||||                           .:|.|| |.|
Yeast   522 LSTILKCNIPLEVIIWNNNGYTIERAIMGPTRSYNDVMSWKWTKLFEAFGDFDGKYT-------- 578

  Fly   492 DLTQITPPSALGVQVRYEEMMKMFGMKGYFCTEI--------EQLQAAVKAA 535
            :.|.|..||.|.:::  ||:.......|....|:        |||:..|:||
Yeast   579 NSTLIQCPSKLALKL--EELKNSNKRSGIELLEVKLGELDFPEQLKCMVEAA 628

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hacl	NP_611460.1	PRK09259	8..552	CDD:236433	136/637 (21%)
		TPP_PYR_POX_like	8..161	CDD:132918	44/185 (24%)
		TPP_enzyme_M	195..322	CDD:278628	27/134 (20%)
		TPP_BZL_OCoD_HPCL	367..550	CDD:238962	49/227 (22%)
ARO10	NP_010668.3	PDC1	22..635	CDD:226470	136/637 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S956
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.860