Protein Alignment Hacl and THI3

DIOPT Version :9

• Sequence 1: NP_611460.1
• Gene: Hacl / 37285
• FlyBaseID: FBgn0034488
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: NP_010203.1
• Gene: THI3 / 851479
• SGDID: S000002238
• Length: 609
• Species: Saccharomyces cerevisiae
• Alignment Length: 636
• Identity: 139/636 - (21%)
• Similarity: 227/636 - (35%)
• Gaps: 166/636 - (26%)

  Fly    14 LKQQGVEYVFGIIG---IPVIELSMAFQAAGLKYIGMRNEQAACYAAQAIGYLTGKPGVCLVVS- 74
            |.|..:..:||:.|   :|:  |...:....|::.|..||..|.|||.  ||...|...||:.:
Yeast    25 LNQLNIHTIFGLSGEFSMPL--LDKLYNIPNLRWAGNSNELNAAYAAD--GYSRLKGLGCLITTF 85

  Fly    75 GPGLLHVTGGMANAQVNCWPLIVIGG------ATNQ---DHE-GIGGFQECPQVELSRPYCKYAA 129
            |.|.|....|:|.:......::.|.|      .|.|   .|. |.|.|....:: .|...| |..
Yeast    86 GVGELSAINGVAGSYAEHVGILHIVGMPPTSAQTKQLLLHHTLGNGDFTVFHRI-ASDVAC-YTT 148

  Fly   130 RPATAALIPLHVEKAVRYA-TYGRPGVAYLDFPGNILQSKAQEASIYKAL---AHPAPPLAYPPH 190
            ....:.|....|:|.::.| ...||  .|:..|.|.:....:.|.:...|   .|...|   ...
Yeast   149 LIIDSELCADEVDKCIKKAWIEQRP--VYMGMPVNQVNLPIESARLNTPLDLQLHKNDP---DVE 208

  Fly   191 DDVI-RAAKLLRQAKRPLVIVGKGSAYAHAENTLRHFIENTNLPFLPTPMGKGVVSDTAPQ---- 250
            .:|| |....:.:::.|.:||...::..:.....:........|...||||||.|::|.||
Yeast   209 KEVISRILSFIYKSQNPAIIVDACTSRQNLIEETKELCNRLKFPVFVTPMGKGTVNETDPQFGGV 273

  Fly   251 ---CVSSARTL-ALQKADVVLLLGARLNWI----LHF-----GKAPRYDKDVKFIQVDINPEELH 302
               .:|:.... .:..||.::::|..|:..    .||     ..|..|...||          |.
Yeast   274 FTGSISAPEVREVVDFADFIIVIGCMLSEFSTSTFHFQYKTKNCALLYSTSVK----------LK 328

  Fly   303 NSVVASVAIQADIRPFAEQLFEQMNAVNFRFGYE---------------------QDW-WKQLAV 345
            |:....::|:..::.....|.|.      :..|:                     |:| |.:::
Yeast   329 NATYPDLSIKLLLQKILANLDES------KLSYQPSEQPSMMVPRPYPAGNVLLRQEWVWNEIS- 386

  Fly   346 KCKQNRDTVQKMSLNTETPLNYYAVFHHLRELLPKDTIIVSEGANTMDIGRSMLLNEQPRHRLDA 410
                                      |..:   |.|.||...||:...:.::         |...
Yeast   387 --------------------------HWFQ---PGDIIITETGASAFGVNQT---------RFPV 413

  Fly   411 GTFG-----------TMGVGPGFAVAAALFCRDFAPG--KRVLCVEGDSAFGFSGMEIETMVRYK 462
            .|.|           |||...|...|.....:|..|.  .||:...||.||..:..|:.|:|::.
Yeast   414 NTLGISQALWGSVGYTMGACLGAEFAVQEINKDKFPATKHRVILFMGDGAFQLTVQELSTIVKWG 478

  Fly   463 LPVTIVIVNNNGIYGGFDKDTFEAIRSEGDLTQITPPSALGVQVRYEEMMKMFGMKGYFCTEIE- 526
            |...|.::||.    |:..|.|...||:.....|.|.:.||       ::::||     ||..|
Yeast   479 LTPYIFVMNNQ----GYSVDRFLHHRSDASYYDIQPWNYLG-------LLRVFG-----CTNYET 527

  Fly   527 -------QLQAAVKAANQLT-DRPTIINVAISPSSDRKPQSF--NWLTESK 567
                   :.::.:...|..| |:..:|.:.:.|..  .||:.  .|:.|.:
Yeast   528 KKIITVGEFRSMISDPNFATNDKIRMIEIMLPPRD--VPQALLDRWVVEKE 576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hacl	NP_611460.1	PRK09259	8..552	CDD:236433	134/617 (22%)
		TPP_PYR_POX_like	8..161	CDD:132918	43/161 (27%)
		TPP_enzyme_M	195..322	CDD:278628	29/143 (20%)
		TPP_BZL_OCoD_HPCL	367..550	CDD:238962	48/204 (24%)
THI3	NP_010203.1	PDC1	12..579	CDD:226470	139/636 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S956
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.860