DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hacl and AT5G17380

DIOPT Version :9

Sequence 1:	NP_611460.1	Gene:	Hacl / 37285	FlyBaseID:	FBgn0034488	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_197240.1	Gene:	AT5G17380 / 831604	AraportID:	AT5G17380	Length:	572	Species:	Arabidopsis thaliana

Alignment Length:	557	Identity:	223/557 - (40%)
Similarity:	337/557 - (60%)	Gaps:	28/557 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IIAESLKQQGVEYVFGIIGIPVIELSMAFQAAGLKYIGMRNEQAACYAAQAIGYLTGKPGVCLVV 73
            ::|:||...||.::||::||||..|:....|.|:::|...|||:|.|||.|.||||||||:.|.|
plant    17 LVAKSLSHLGVTHMFGVVGIPVTSLASRAMALGIRFIAFHNEQSAGYAASAYGYLTGKPGILLTV 81

  Fly    74 SGPGLLHVTGGMANAQVNCWPLIVIGGATNQDHEGIGGFQECPQVELSRPYCKYAARPATAALIP 138
            ||||.:|...|::||.||.||:::|.|:.:|...|.|.|||..|:|..:.:.|.:.:......||
plant    82 SGPGCVHGLAGLSNAWVNTWPMVMISGSCDQRDVGRGDFQELDQIEAVKAFSKLSEKAKDVREIP 146

  Fly   139 LHVEKAVRYATYGRPGVAYLDFPGNILQSKAQEASIYKAL-----AHPAPPLAYPPHDDVIRAAK 198
            ..|.:.:..|..||||..|||.|.::|:.|..|:...|.:     :....|:......::..|..
plant   147 DCVSRVLDRAVSGRPGGCYLDIPTDVLRQKISESEADKLVDEVERSRKEEPIRGSLRSEIESAVS 211

  Fly   199 LLRQAKRPLVIVGKGSAYAHAENTLRHFIENTNLPFLPTPMGKGVVSDTAPQCVSSARTLALQKA 263
            |||:|:|||::.|||:||:.||:.|:..:|.|.:||||||||||::.||.....::||:||:.|.
plant   212 LLRKAERPLIVFGKGAAYSRAEDELKKLVEITGIPFLPTPMGKGLLPDTHEFSATAARSLAIGKC 276

  Fly   264 DVVLLLGARLNWILHFGKAPRYDKDVKFIQVDINPEEL-----HNSVVASVAIQADIRPFAEQLF 323
            ||.|::||||||:||||::|::|||||||.||::.||:     |..:|      .|.:.....|.
plant   277 DVALVVGARLNWLLHFGESPKWDKDVKFILVDVSEEEIELRKPHLGIV------GDAKTVIGLLN 335

  Fly   324 EQMNAVNFRFGYEQDWWKQLAVKCKQNRDTVQKMSLNTETPLNYYAVFHHLRELL----PKDTII 384
            .::....|..|....|.:.::.|.|:|.:.::........|.|:......:|:.:    ....::
plant   336 REIKDDPFCLGKSNSWVESISKKAKENGEKMEIQLAKDVVPFNFLTPMRIIRDAILAVEGPSPVV 400

  Fly   385 VSEGANTMDIGRSMLLNEQPRHRLDAGTFGTMGVGPGFAVAAALFCRDFAPGKRVLCVEGDSAFG 449
            |||||||||:|||:|:.::||.||||||:||||||.|:.:|||:    .:|.:.|:.|||||.||
plant   401 VSEGANTMDVGRSVLVQKEPRTRLDAGTWGTMGVGLGYCIAAAV----ASPDRLVVAVEGDSGFG 461

  Fly   450 FSGMEIETMVRYKLPVTIVIVNNNGIYGGFDKDTFEAIRSEGDLTQITPPSALGVQVRYEEMMKM 514
            ||.||:||:|||.|.|.|::.||.|:||| |:...|.|  .|...:...|::......|.::::.
plant   462 FSAMEVETLVRYNLAVVIIVFNNGGVYGG-DRRGPEEI--SGPHKEDPAPTSFVPNAGYHKLIEA 523

  Fly   515 FGMKGYFCTEIEQLQAAVKAANQLTDRPTIINVAISP 551
            ||.|||.....::|::|: |.:....:|.::||.|.|
plant   524 FGGKGYIVETPDELKSAL-AESFAARKPAVVNVIIDP 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hacl	NP_611460.1	PRK09259	8..552	CDD:236433	223/557 (40%)
		TPP_PYR_POX_like	8..161	CDD:132918	67/151 (44%)
		TPP_enzyme_M	195..322	CDD:278628	63/131 (48%)
		TPP_BZL_OCoD_HPCL	367..550	CDD:238962	76/186 (41%)
AT5G17380	NP_197240.1	PRK09259	1..572	CDD:236433	223/557 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	148	1.000	Domainoid score	I1441
eggNOG	1	0.900	-	-		E1_COG0028
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5794
Inparanoid	1	1.050	414	1.000	Inparanoid score	I448
OMA	1	1.010	-	-		QHG62113
OrthoDB	1	1.010	-	-		D330201at2759
OrthoFinder	1	1.000	-	-		FOG0004290
OrthoInspector	1	1.000	-	-		oto3857
orthoMCL	1	0.900	-	-		OOG6_100369
Panther	1	1.100	-	-	LDO	PTHR43710
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3024
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840