DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hacl and hacl1

DIOPT Version :9

Sequence 1:	NP_611460.1	Gene:	Hacl / 37285	FlyBaseID:	FBgn0034488	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_001017332.1	Gene:	hacl1 / 550086	XenbaseID:	XB-GENE-982243	Length:	577	Species:	Xenopus tropicalis

Alignment Length:	566	Identity:	305/566 - (53%)
Similarity:	404/566 - (71%)	Gaps:	2/566 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VEAVQIIAESLKQQGVEYVFGIIGIPVIELSMAFQAAGLKYIGMRNEQAACYAAQAIGYLTGKPG 68
            |...|||||:|..|.|:|:|||:||||||:::|.||||:||:||||||||||||.|:|||||:||
Frog    13 VTGAQIIAEALVAQNVKYMFGIVGIPVIEIAVAAQAAGIKYVGMRNEQAACYAASAVGYLTGRPG 77

  Fly    69 VCLVVSGPGLLHVTGGMANAQVNCWPLIVIGGATNQDHEGIGGFQECPQVELSRPYCKYAARPAT 133
            ||||||||||::...||||:.:|||||||:.|:::.:.|.:|.|||.||||.||.|.|::|||::
Frog    78 VCLVVSGPGLINALSGMANSNMNCWPLIVLAGSSDTNQETMGAFQEFPQVETSRLYSKFSARPSS 142

  Fly   134 AALIPLHVEKAVRYATYGRPGVAYLDFPGNILQSKAQEASI-YKALAHPAPPLAYPPHDDVIRAA 197
            ...||:.:|||||.:.|||||..|:|.||:.:......:.: |.....| ||.:......|.:|.
Frog   143 LEAIPVVIEKAVRSSIYGRPGSCYVDIPGDFVNKMVNRSDVRYTECCLP-PPTSLADPTAVHKAV 206

  Fly   198 KLLRQAKRPLVIVGKGSAYAHAENTLRHFIENTNLPFLPTPMGKGVVSDTAPQCVSSARTLALQK 262
            ..|:.|::||||||||:|::.||.::...:::..|||||||||||||.|..|.||::||:.|||.
Frog   207 LELKNAQQPLVIVGKGAAFSRAERSISKLVQDCGLPFLPTPMGKGVVPDNHPNCVAAARSSALQN 271

  Fly   263 ADVVLLLGARLNWILHFGKAPRYDKDVKFIQVDINPEELHNSVVASVAIQADIRPFAEQLFEQMN 327
            |||:||||||||||||||..||:..|||.||:||..|||.|:|..:.::..||....:||.|.::
Frog   272 ADVILLLGARLNWILHFGLPPRFRPDVKIIQIDICAEELGNNVKPAASLLGDIDAVTQQLLENIS 336

  Fly   328 AVNFRFGYEQDWWKQLAVKCKQNRDTVQKMSLNTETPLNYYAVFHHLRELLPKDTIIVSEGANTM 392
            ..::::....:|||.|..|.:.|.:..:.::..|..|:|||.||.::::.||.:.||||||||||
Frog   337 ETSWKYPASAEWWKILRAKIRSNEENSKVLASQTSLPMNYYTVFKYVKDALPSNCIIVSEGANTM 401

  Fly   393 DIGRSMLLNEQPRHRLDAGTFGTMGVGPGFAVAAALFCRDFAPGKRVLCVEGDSAFGFSGMEIET 457
            ||||::|.|..||||||||||||||||.|||:|||:..:|..|.:||:|:||||||||||||.||
Frog   402 DIGRTVLPNYHPRHRLDAGTFGTMGVGLGFAIAAAMITKDECPEQRVVCIEGDSAFGFSGMEAET 466

  Fly   458 MVRYKLPVTIVIVNNNGIYGGFDKDTFEAIRSEGDLTQITPPSALGVQVRYEEMMKMFGMKGYFC 522
            |.|||||:.|::|||||||.|||:.|:..:...||...:.||.||.....||::||.||.||||.
Frog   467 MCRYKLPIIIIVVNNNGIYNGFDEGTWNEMMESGDPATMAPPVALMPNAHYEQVMKAFGGKGYFA 531

  Fly   523 TEIEQLQAAVKAANQLTDRPTIINVAISPSSDRKPQSFNWLTESKL 568
            ...|:||.|:|::......|::|||.|.|.||||.|.|:|||.|.|
Frog   532 RTPEELQNALKSSFAEKAVPSLINVMIDPVSDRKKQEFHWLTRSNL 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hacl	NP_611460.1	PRK09259	8..552	CDD:236433	292/544 (54%)
		TPP_PYR_POX_like	8..161	CDD:132918	97/152 (64%)
		TPP_enzyme_M	195..322	CDD:278628	69/126 (55%)
		TPP_BZL_OCoD_HPCL	367..550	CDD:238962	106/182 (58%)
hacl1	NP_001017332.1	PRK09259	7..560	CDD:236433	293/547 (54%)
		TPP_PYR_POX_like	17..170	CDD:132918	97/152 (64%)
		TPP_enzyme_M	202..331	CDD:278628	70/128 (55%)
		TPP_BZL_OCoD_HPCL	376..559	CDD:238962	106/182 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	217	1.000	Domainoid score	I2630
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H5794
Inparanoid	1	1.050	613	1.000	Inparanoid score	I893
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D158397at33208
OrthoFinder	1	1.000	-	-		FOG0004290
OrthoInspector	1	1.000	-	-		oto103181
Panther	1	1.100	-	-	LDO	PTHR43710
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1849
SonicParanoid	1	1.000	-	-		X3024
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.190