DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hacl and hacl1

DIOPT Version :9

Sequence 1:	NP_611460.1	Gene:	Hacl / 37285	FlyBaseID:	FBgn0034488	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_998250.1	Gene:	hacl1 / 406358	ZFINID:	ZDB-GENE-040426-2058	Length:	568	Species:	Danio rerio

Alignment Length:	568	Identity:	316/568 - (55%)
Similarity:	416/568 - (73%)	Gaps:	0/568 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAEVEAVQIIAESLKQQGVEYVFGIIGIPVIELSMAFQAAGLKYIGMRNEQAACYAAQAIGYLTG 65
            |.||...|:||.:||.|.|||:|||:|:|:||::||.||||:||:||||||||||||.|||||||
Zfish     1 MDEVTGAQLIAAALKDQNVEYMFGIVGVPIIEVAMAAQAAGIKYVGMRNEQAACYAASAIGYLTG 65

  Fly    66 KPGVCLVVSGPGLLHVTGGMANAQVNCWPLIVIGGATNQDHEGIGGFQECPQVELSRPYCKYAAR 130
            :|.||||||||||:|..||||||.|||||:||:||:::::.|..|.|||.||||..|.|.|::||
Zfish    66 RPAVCLVVSGPGLIHALGGMANANVNCWPVIVLGGSSDRNQETTGAFQEFPQVEACRLYSKFSAR 130

  Fly   131 PATAALIPLHVEKAVRYATYGRPGVAYLDFPGNILQSKAQEASIYKALAHPAPPLAYPPHDDVIR 195
            |::..:||..||||||.:.|||||..|:|..|:::.:|...|::......||||::.....::.:
Zfish   131 PSSLEMIPAVVEKAVRSSIYGRPGACYIDIAGDMVNAKIDRATVRFVSCCPAPPVSQADCREITQ 195

  Fly   196 AAKLLRQAKRPLVIVGKGSAYAHAENTLRHFIENTNLPFLPTPMGKGVVSDTAPQCVSSARTLAL 260
            |.:||:.::.||:|:|||:|||.||..:|..:|.|.:|||||||||||:.|..|.||::||:.||
Zfish   196 AVRLLKTSQSPLIIIGKGAAYARAEKEVRELVEVTGIPFLPTPMGKGVLPDDHPNCVAAARSRAL 260

  Fly   261 QKADVVLLLGARLNWILHFGKAPRYDKDVKFIQVDINPEELHNSVVASVAIQADIRPFAEQLFEQ 325
            .:|||::|||||||||||||..||:..:||.||||:..|||.|:|.|:.|:..||:....||.|.
Zfish   261 LQADVIVLLGARLNWILHFGFPPRFSANVKIIQVDLCAEELSNNVRAASALLGDIKMVTSQLLET 325

  Fly   326 MNAVNFRFGYEQDWWKQLAVKCKQNRDTVQKMSLNTETPLNYYAVFHHLRELLPKDTIIVSEGAN 390
            :.:.::||..:..||..|..|...|....:.:||.|..|:|||..|||:.||||||.||||||||
Zfish   326 VRSESWRFPSDSQWWATLREKITANAQITKALSLQTTLPMNYYTAFHHISELLPKDCIIVSEGAN 390

  Fly   391 TMDIGRSMLLNEQPRHRLDAGTFGTMGVGPGFAVAAALFCRDFAPGKRVLCVEGDSAFGFSGMEI 455
            ||||||:||||..||||||||||||||||||||:|||:..:....|::|:||||||||||||||.
Zfish   391 TMDIGRTMLLNHLPRHRLDAGTFGTMGVGPGFAIAAAVLEQAQRFGQKVVCVEGDSAFGFSGMEA 455

  Fly   456 ETMVRYKLPVTIVIVNNNGIYGGFDKDTFEAIRSEGDLTQITPPSALGVQVRYEEMMKMFGMKGY 520
            |||.|||||:.|:::||||||.|.|.:|::|:...||:|.|.||..|..:.|||::|..||..||
Zfish   456 ETMCRYKLPIIIIVINNNGIYSGVDPETWKAMEKMGDMTTIAPPVTLLPEARYEQVMSAFGGHGY 520

  Fly   521 FCTEIEQLQAAVKAANQLTDRPTIINVAISPSSDRKPQSFNWLTESKL 568
            ....:|:|:.|::.:.:.|..|:::||.|.|:||||.|.|.|||.|.|
Zfish   521 LVRTVEELRTALQDSLKNTQMPSLLNVLIDPTSDRKQQEFPWLTRSNL 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hacl	NP_611460.1	PRK09259	8..552	CDD:236433	301/543 (55%)
		TPP_PYR_POX_like	8..161	CDD:132918	100/152 (66%)
		TPP_enzyme_M	195..322	CDD:278628	69/126 (55%)
		TPP_BZL_OCoD_HPCL	367..550	CDD:238962	109/182 (60%)
hacl1	NP_998250.1	PRK09259	5..552	CDD:236433	301/546 (55%)
		TPP_PYR_POX_like	8..160	CDD:132918	99/151 (66%)
		TPP_enzyme_M	193..322	CDD:278628	69/128 (54%)
		TPP_BZL_OCoD_HPCL	367..550	CDD:238962	109/182 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576412
Domainoid	1	1.000	225	1.000	Domainoid score	I2480
eggNOG	1	0.900	-	-		E1_COG0028
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5794
Inparanoid	1	1.050	661	1.000	Inparanoid score	I744
OMA	1	1.010	-	-		QHG62113
OrthoDB	1	1.010	-	-		D158397at33208
OrthoFinder	1	1.000	-	-		FOG0004290
OrthoInspector	1	1.000	-	-		oto39656
orthoMCL	1	0.900	-	-		OOG6_100369
Panther	1	1.100	-	-	LDO	PTHR43710
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1849
SonicParanoid	1	1.000	-	-		X3024
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800