Protein Alignment Hacl and ilv1

DIOPT Version :9

• Sequence 1: NP_611460.1
• Gene: Hacl / 37285
• FlyBaseID: FBgn0034488
• Length: 568
• Species: Drosophila melanogaster
• Sequence 2: NP_595382.1
• Gene: ilv1 / 2541345
• PomBaseID: SPBP35G2.07
• Length: 669
• Species: Schizosaccharomyces pombe
• Alignment Length: 623
• Identity: 149/623 - (23%)
• Similarity: 253/623 - (40%)
• Gaps: 149/623 - (23%)

  Fly     8 QIIAESLKQQGVEYVFGIIG---IPVIELSMAFQAAGLKYIGMRNEQAACYAAQAIGYLTGKPGV 69
            :|..:.:.:..|::|||..|   :||.:  ..:::...::|..|:||||.:||||...:|.||||
pombe    91 EIFHDMMLKHNVKHVFGYPGGAILPVFD--AIYRSPHFEFILPRHEQAAGHAAQAYSRVTKKPGV 153

  Fly    70 CLVVSGPGLLHVTGGMANAQVNCWPLIVIGGATNQDHEGIGGFQECPQVELSRPYCKYAARPATA 134
            .||.||||..:|...:|:|..:..||:|..|.......|...|||...|.:||...|:.......
pombe   154 VLVTSGPGATNVITPIADALADGTPLVVFSGQVATSAIGSDAFQEADMVGISRSCTKWNVMVKDV 218

  Fly   135 ALIPLHVEKAVRYATYGRPGVAYLDFPGNILQSKAQEASIYKALAHPAPPLAYPPHDD------- 192
            |.:|..:::|...||.||||...:|.|.::..|         .|..|.|.|:..|..:
pombe   219 ADLPRRIDEAFEIATSGRPGPVLVDLPKDVTAS---------VLKEPIPILSSVPSMNRRMKEVL 274

  Fly   193 ----------VIRAAKLLRQAKRPLVIVGKG-SAYAHAENTLRHFIENTNLPFLPTPMGKGVVSD 246
                      :.|.|.||:.||:|::..|.| .|.......||.|.|...:|...:.:|.|.|.:
pombe   275 EEGSKNVTAKIDRVANLLKLAKKPVIFCGHGVLANPECPTLLRKFSERLQIPVTTSLLGLGAVDE 339

  Fly   247 TAPQCV-------SSARTLALQKADVVLLLGARLN-----------------------WILHFGK 281
            .:...:       |....:|:|:||::|.||.|.:                       .|:||
pombe   340 RSDLSLHMLGMHGSGYANMAMQEADLILALGVRFDDRVTGNVSLFAPQARLAAAEERGGIIHF-- 402

  Fly   282 APRYDKDVKFIQVDINPEELHNSVVASVAIQADIRPFAEQLFEQMNAV-----NFRFGYEQDWWK 341
                         ||:|:.:...|..:.||:.|:       :|.:..:     |.:.....||..
pombe   403 -------------DISPKNIGKVVQPTEAIEGDV-------YESLKLLDSATKNIKIPSRFDWLS 447

  Fly   342 QLAV---------------KCKQNRDTVQKMSLNTETPLNYYAVFHHLRELLPKDTIIVSEGANT 391
            |:..               :..:.::.:|::...|.             ::..|.||....||:.
pombe   448 QIQTWKERFPFTFTRSAPGELVKPQEVIQELDKQTS-------------DIKDKVTITTGVGAHQ 499

  Fly   392 MDIGRSMLLNEQPRHRLDAGTFGTMGVGPGFAVAAALFCRDFAPGKRVLCVEGDSAFGFSGMEIE 456
            | ...:.....:|...:.:|..||||.|...|:.|::    .||...|:.::||::|..:|||:.
pombe   500 M-WAATFYRWTKPSSLVTSGGLGTMGFGLPAAIGASV----AAPKDIVIDIDGDASFSMTGMELA 559

  Fly   457 TMVRYKLPVTIVIVNNNGIYGGFDKDTFEAIRSEGDLTQITPPSALGVQVRYE-------EMMKM 514
            |:.::.:||.|:|:||               ..:|.:||.   ..|..:.||.       ..:|:
pombe   560 TVRQFDIPVKILILNN---------------EEQGMVTQW---QNLFYEKRYSHTHQKNPNFVKL 606

  Fly   515 FGMKGYFCTEIEQLQAAVKAANQL--TDRPTIINVAIS 550
            ....|.....:|:.:...|...:.  |..|.::.|.::
pombe   607 ADAMGIKALRVEKREDLAKKMKEFLSTKGPVLMEVLVA 644

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hacl	NP_611460.1	PRK09259	8..552	CDD:236433	149/623 (24%)
		TPP_PYR_POX_like	8..161	CDD:132918	54/155 (35%)
		TPP_enzyme_M	195..322	CDD:278628	37/157 (24%)
		TPP_BZL_OCoD_HPCL	367..550	CDD:238962	44/191 (23%)
ilv1	NP_595382.1	acolac_lg	88..664	CDD:272915	149/623 (24%)
		TPP_PYR_POX_like	91..246	CDD:132918	54/156 (35%)
		TPP_enzyme_M	285..430	CDD:278628	38/166 (23%)
		TPP_AHAS	469..656	CDD:238973	46/212 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100369
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.710