DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hacl and SPBC725.04

DIOPT Version :9

Sequence 1:	NP_611460.1	Gene:	Hacl / 37285	FlyBaseID:	FBgn0034488	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_595484.1	Gene:	SPBC725.04 / 2541142	PomBaseID:	SPBC725.04	Length:	568	Species:	Schizosaccharomyces pombe

Alignment Length:	569	Identity:	231/569 - (40%)
Similarity:	348/569 - (61%)	Gaps:	19/569 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 QIIAESLKQQGVEYVFGIIGIPVIELSMAFQAAGLKYIGMRNEQAACYAAQAIGYLTGKPGVCLV 72
            :::|::|....|:.||||:||||||:..|.||:|::::|.||||:|.|||.|.||||.:||||:|
pombe     7 ELVAKTLLDLEVKVVFGIVGIPVIEICEAIQASGIRFVGFRNEQSAAYAATAYGYLTQRPGVCVV 71

  Fly    73 VSGPGLLHVTGGMANAQVNCWPLIVIGGATNQDHEGIGGFQECPQVELSRPYCKYAARPATAALI 137
            |.|||::|...|:.|::.|.|||:::.|::....:..|.|||..||....|:.|.|.||.:..::
pombe    72 VGGPGVVHAMAGVFNSKTNRWPLLLLAGSSETFQQNCGAFQELDQVSYLSPHTKLAVRPPSPKMV 136

  Fly   138 PLHVEKAVRYATYGRPGVAYLDFPGNILQSKAQEASIYKALAHPAPPLAYPPHDDVIRAAKLLRQ 202
            ...:.:|.|.:..|.||..|:|.|.|.::|...:.........|:.|...|....:.:||..|:.
pombe   137 VDSIRRAYRVSMTGTPGTCYVDLPANYIESTVDDFPKDPLPPIPSSPKCAPDPTQLQKAAYYLKN 201

  Fly   203 AKRPLVIVGKGSAYAHAENTLRHFIENTNLPFLPTPMGKGVVSDTAPQCVSSARTLALQKADVVL 267
            ||.||::||||:|||.||..|..|:|:|.:||||:|||||::.::.|..|||||:.||:.|||||
pombe   202 AKAPLLVVGKGAAYACAEKQLLEFVEHTGIPFLPSPMGKGLLPESHPLNVSSARSAALRNADVVL 266

  Fly   268 LLGARLNWILHFGKAPRYDKDVKFIQVDINPEEL-HNSVVASVAIQADIRPFAEQLFEQMNAVNF 331
            |.|||||||..:|..|::..:.||||:|.|.|.| :|:....:||.||:....:.||:.:....:
pombe   267 LAGARLNWIFQYGLPPKWSPNAKFIQIDTNAETLGNNAADLDLAIWADVGLTIDCLFKLVQTWKY 331

  Fly   332 RFGYEQDWWKQL-AVKCKQNRDTVQKMSLNTETPLNY--YAVFHHLRELLPK---DTIIVSEGAN 390
            ..|....:.:.| ..:.|..:..::....:....:||  |.|...|:.|..|   :...||||||
pombe   332 SVGISTPYLRTLNETRSKNEKKALESRKSSIPLQMNYALYVVNEELQSLSLKSKRNITWVSEGAN 396

  Fly   391 TMDIGRSMLLNEQPRHRLDAGTFGTMGVGPGFAVAAALFCRDFA-PGKRVLCVEGDSAFGFSGME 454
            |||.||.:|....||.||||||..|||||.|:|:|:|     || ...:::.||||||||||.||
pombe   397 TMDRGRQLLEVTHPRGRLDAGTMSTMGVGMGYAIASA-----FAHSSDKIVVVEGDSAFGFSAME 456

  Fly   455 IETMVRYKLPVTIVIVNNNGIYGGFDKDTFEAIRSEGDLTQITPPSALGVQVRYEEMMKMFGMKG 519
            :||.:|.:|.:.::::||||:|.|.|.|.:|.:|....|    |.:|||..:||:::.:..|.||
pombe   457 LETAIRNQLDLLVIVINNNGVYHGLDTDAYETLRDNHQL----PTTALGTSIRYDQICEACGGKG 517

  Fly   520 YFCTEIEQLQAAVKAANQLTDRPTIINVAISPSSDRKPQSFNWLTESKL 568
            :|....|.|:::::.|.| |...::|||.:.|.:.|| .:|.|::.:|:
pombe   518 FFVKNEEDLRSSLRKAWQ-TSSVSLINVMVDPEAARK-LTFAWMSSTKV 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hacl	NP_611460.1	PRK09259	8..552	CDD:236433	225/551 (41%)
		TPP_PYR_POX_like	8..161	CDD:132918	66/152 (43%)
		TPP_enzyme_M	195..322	CDD:278628	65/127 (51%)
		TPP_BZL_OCoD_HPCL	367..550	CDD:238962	82/188 (44%)
SPBC725.04	NP_595484.1	TPP_PYR_POX_like	7..161	CDD:132918	66/153 (43%)
		PRK09259	8..550	CDD:236433	226/551 (41%)
		TPP_enzyme_M	192..322	CDD:278628	65/129 (50%)
		TPP_BZL_OCoD_HPCL	367..547	CDD:238962	83/189 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	155	1.000	Domainoid score	I1054
eggNOG	1	0.900	-	-		E1_COG0028
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5794
Inparanoid	1	1.050	425	1.000	Inparanoid score	I334
OMA	1	1.010	-	-		QHG62113
OrthoFinder	1	1.000	-	-		FOG0004290
OrthoInspector	1	1.000	-	-		oto100937
orthoMCL	1	0.900	-	-		OOG6_100369
Panther	1	1.100	-	-	LDO	PTHR43710
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1849
SonicParanoid	1	1.000	-	-		X3024
TreeFam	1	0.960	-	-
	14	13.860