DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hacl and B0334.3

DIOPT Version :9

Sequence 1:	NP_611460.1	Gene:	Hacl / 37285	FlyBaseID:	FBgn0034488	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_496454.1	Gene:	B0334.3 / 174758	WormBaseID:	WBGene00007143	Length:	634	Species:	Caenorhabditis elegans

Alignment Length:	570	Identity:	290/570 - (50%)
Similarity:	386/570 - (67%)	Gaps:	8/570 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 AEVEAVQIIAESLKQQGVEYVFGIIGIPVIELSMAFQAAGLKYIGMRNEQAACYAAQAIGYLTGK 66
            :.::...|.|.:||.|||||:||::|.||||:.||.||.|:||||.||||||.|||||:||||||
Worm    70 SNMDGASITAAALKSQGVEYMFGVVGFPVIEVGMAAQAHGIKYIGCRNEQAAAYAAQAMGYLTGK 134

  Fly    67 PGVCLVVSGPGLLHVTGGMANAQVNCWPLIVIGGATNQDHEGIGGFQECPQVELSRPYCKYAARP 131
            |...|||||||:||..||:|||.|||||::.|||..:.|.|..|.|||..|.|..|..||:.:||
Worm   135 PVALLVVSGPGILHAIGGLANATVNCWPVVCIGGTADVDLENRGAFQEWSQQESVRNSCKHVSRP 199

  Fly   132 ATAALIPLHVEKAVRYATYGRPGVAYLDFPGN-ILQSKAQEASIYKALAHPAPPLAYPPHDDVIR 195
            .:...||.|:|||||.|.|||||..|:|.||| :|.|..:|.|....:..|| |::.||..::.:
Worm   200 TSLHTIPAHIEKAVRCAMYGRPGAVYVDLPGNLVLTSTEEEISFPPQVPLPA-PVSIPPIAEIEK 263

  Fly   196 AAKLLRQAKRPLVIVGKGSAYAHAENT-LRHFIENTNLPFLPTPMGKGVVSDTAPQCVSSARTLA 259
            |...|:.||:||||||||:|::....| ::.|:..:.||:|.||.||||.||..|:.:..||:||
Worm   264 AIDTLKSAKKPLVIVGKGAAWSERGATQVQQFLTKSKLPWLATPGGKGVASDLHPRFIGQARSLA 328

  Fly   260 LQKADVVLLLGARLNWILHFGKAPRYDKDVKFIQVDINPEELHNSVVASVAIQADIRPFAEQLFE 324
            |::||.|.|:|||.|||||||..||:.||||.:|:||.|||.|.:|...|.:..||.....:|..
Worm   329 LREADTVFLIGARFNWILHFGLPPRFQKDVKVVQIDICPEEFHQNVKTEVPLLGDIGETLAELTP 393

  Fly   325 QMNAVNFRFGYEQDWWKQLAVKCKQNRDTVQKMSLNTETPLNYYAVFHHLRELLP-KDTIIVSEG 388
            ::.  ::.:....:|:|:|....::||..|:|...:..|||||||.:..:||.|. .|.|:::||
Worm   394 RLG--DWTYDESTEWFKKLRENAEKNRAAVEKFVDDHSTPLNYYAAYQPIREFLANNDVIVINEG 456

  Fly   389 ANTMDIGRSMLLNEQPRHRLDAGTFGTMGVGPGFAVAAALFCRDFAPGKRVLCVEGDSAFGFSGM 453
            ||||||||:|:.:..|:.|||||||||||||.||::||||:.||.:|..:||.|:||||||||.|
Worm   457 ANTMDIGRTMMPSRLPKRRLDAGTFGTMGVGHGFSLAAALWARDHSPKTKVLVVQGDSAFGFSAM 521

  Fly   454 EIETMVRYKLPVTIVIVNNNGIYGGFDKDTFEAIRSEGDLTQITPPSALGVQVRYEEMMKMFGMK 518
            |:||:.||.|||..||:||:|||.|...:..:||  |||.|...|..:|..:.|||||.|.||..
Worm   522 ELETIARYNLPVVTVIINNSGIYRGLLPEDDKAI--EGDRTLALPVLSLTAECRYEEMCKAFGGA 584

  Fly   519 GYFCTEIEQLQAAVKAANQLTDRPTIINVAISPSSDRKPQSFNWLTESKL 568
            |.....:.:::||::.|.|.||.||:||..||..|:||||:.:|||.||:
Worm   585 GTVVRTVPEIKAALEKAFQKTDGPTVINALISTDSERKPQADHWLTRSKM 634

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hacl	NP_611460.1	PRK09259	8..552	CDD:236433	280/546 (51%)
		TPP_PYR_POX_like	8..161	CDD:132918	94/152 (62%)
		TPP_enzyme_M	195..322	CDD:278628	63/127 (50%)
		TPP_BZL_OCoD_HPCL	367..550	CDD:238962	97/183 (53%)
B0334.3	NP_496454.1	PRK09259	68..615	CDD:236433	278/549 (51%)
		TPP_enzyme_N	74..240	CDD:280871	99/165 (60%)
		TPP_enzyme_M	261..391	CDD:278628	63/129 (49%)
		TPP_BZL_OCoD_HPCL	434..616	CDD:238962	97/183 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157623
Domainoid	1	1.000	207	1.000	Domainoid score	I1689
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5794
Inparanoid	1	1.050	557	1.000	Inparanoid score	I598
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62113
OrthoDB	1	1.010	-	-		D158397at33208
OrthoFinder	1	1.000	-	-		FOG0004290
OrthoInspector	1	1.000	-	-		oto17274
orthoMCL	1	0.900	-	-		OOG6_100369
Panther	1	1.100	-	-	LDO	PTHR43710
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3024
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910