Protein Alignment Efhc1.2 and EFHC2

DIOPT Version :10

• Sequence 1: NP_611459.1
• Gene: Efhc1.2 / 37284
• FlyBaseID: FBgn0034487
• Length: 765
• Species: Drosophila melanogaster
• Sequence 2: NP_079460.2
• Gene: EFHC2 / 80258
• HGNCID: 26233
• Length: 749
• Species: Homo sapiens
• Alignment Length: 791
• Identity: 272/791 - (34%)
• Similarity: 421/791 - (53%)
• Gaps: 82/791 - (10%)

  Fly     7 MPMLPGAQF-YDRGKRRHPRQQTLMHYQGIQML-SDRR-----EPELVEPNGIVADPKCPPVPAQ 64
            :|:|||..| .:.||.:..:.|.......:.|| ||.:     ||.|    |....|||
Human     3 LPLLPGNSFNRNVGKEKFHKSQHWGFCNNVMMLVSDEKPGIGGEPLL----GQKIKPKC------ 57

  Fly    65 LNSLWAPKATTKLPPWLAYDKQVLCFNAYFKENLTEIYHAPYQVRKVKIFFYLEDGTMQVTEPKV 129
              |::.....:.:|.|:|:|||||.|:||.:|.:.:.....|::|..||:||.||.|:||.||:|
Human    58 --SIYPKGDGSDVPSWVAFDKQVLSFDAYLEEEVLDKSQTNYRIRYYKIYFYPEDDTIQVNEPEV 120

  Fly   130 ENSGIPQGCLVHRQRIPKAPPTDREFISIFDLNVDTDVQIFDRVYHISGCDVFTRQFLNRAGIFV 194
            :|||:.||..:.|.||...||.:.:|.:::..||.|:|..:.|.:.|..||.|||.||.:.|:.|
Human   121 KNSGLLQGTSIRRHRITLPPPDEDQFYTVYHFNVGTEVVFYGRTFKIYDCDAFTRNFLRKIGVKV 185

  Fly   195 PEAQQEPCDPTTEIRKR-----SGLKQTGNTATSALPKKHAFAQFLEFDRRVLKFQGYWNDR-SE 253
            ....|.|.||..:||:.     ..|:...:..|        ..|||::..::|.|...|:|. |.
Human   186 NPPVQCPEDPYMKIRREVVEHVEPLRPYESLDT--------LKQFLQYHGKILCFFCLWDDSVSM 242

  Fly   254 FGDVRKLEVCYYLADDTIDIKEKFPRNSGREGPTTFLKRGKLPKEFSGLP----LPGQQTAMTLL 314
            |||.|:|.:.|:|.||||:|||..|.:|||:....||:|.||||   ..|    .|||.|...:|
Human   243 FGDRRELILHYFLCDDTIEIKELLPHSSGRDALKMFLRRSKLPK---NCPPRVYQPGQITDRAVL 304

  Fly   315 NVLGNSMRDVR--YVADPLNTGQKEVQHYTDQDLQIGAVLNVFGRSVVLTSCDQFTQSYYREKYG 377
            |..|:.:::..  |:.|....|:.:.:.|.|.||.:|..:||:||.|:|..||:||:|||:.|||
Human   305 NSYGDFIKNQADGYLFDRYKLGKVDQEFYKDSDLSLGVTINVWGRKVLLYDCDEFTKSYYKSKYG 369

  Fly   378 IQEFS------PQPIPERSDIRPYTQGGMGSRRLPPYNGWGSHEDSEGNCITVEPKPPQADFKKL 436
            |:.|:      |.|.|:.            .|:.|||||:||.|||..|||.::|.|.:.:|||.
Human   370 IENFTSVSCKPPSPPPKI------------ERKFPPYNGFGSEEDSLRNCIDLKPTPHRRNFKKF 422

  Fly   437 FKYDGC-----ILRFGAKLISAIRDNGERDFVISYFLADDTLQIYETSRRNSGFLGGEFLKRARV 496
            .:.|..     ||||.|||::....:.:|.|||||:|.|||:.::|...||||..||.||||:||
Human   423 MEKDSYGSKSNILRFFAKLVTDKCVDLDRMFVISYYLGDDTISVFEPIERNSGIAGGMFLKRSRV 487

  Fly   497 PLPGQDMYSSSRPEYYRANDFYIGRTMTLKDHIFHIVSADEFTLMYMEQHPSEFPVADIQKIMQK 561
            ..|||:::.|...||.:|.:.|||.|:.:..::|.:::|||:||.||||:..::|.::::..:||
Human   488 KKPGQEVFKSELSEYIKAEELYIGVTVNVNGYLFRLLNADEYTLNYMEQNTDKYPFSNLKLALQK 552

  Fly   562 IR--EAVRPDYKQFVLRCKPDGDLGDYTAVSFETLRSTLLSYLSKDCLLNHEIVTVCRFFSAEQA 624
            ::  |....:.|| |.:.   .|......|.:.|.|..|:| |:...|...|.||:.|.:...:.
Human   553 LKQEEGKSRELKQ-VFKA---ADSKHTNMVDYNTFRDILMS-LTVGNLAEQEFVTIARHYRVPEG 612

  Fly   625 MPPSC-DRNRVRAAAQLELKRALWNGMDQLNDHLSHINPACKPYISEGQVRSTLRGCRLPFSLEL 688
               :| |.:.:.|.|..:.|:.::...|.......:.:...|..:....::...:..|||.|.:|
Human   613 ---TCSDMDFLIALAHEKFKKNMFENFDTFIYSCVYEDREKKNVLPTKDIKRLCKSSRLPLSDDL 674

  Fly   689 VEDILMVLQRNGQNEIEVRDFLAFFNMRNDQVPDIAPLNIAFELCPK----LPFLHKGRLVDFTW 749
            :|.:|...: :.:.:|:.:.|.:..|.|.:.||::.|.:...|.|..    :|.....:.:|:..
Human   675 LESLLSRFE-DSEKQIDYKSFFSALNWRKNPVPELQPASYLKERCEDVWLGMPSPIPAKYIDYWT 738

  Fly   750 FL-DYLGIEEE 759
            || |..|:|||
Human   739 FLKDAFGLEEE 749

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Efhc1.2	NP_611459.1	DM10	84..191	CDD:128921	47/106 (44%)
		DM10_dom	231..368	CDD:461948	57/143 (40%)
		DM10	440..547	CDD:128921	52/111 (47%)
EFHC2	NP_079460.2	DM10	75..182	CDD:128921	47/106 (44%)
		DM10	226..368	CDD:128921	59/144 (41%)
		DM10_dom	419..530	CDD:461948	49/110 (45%)