Protein Alignment Efhc1.2 and Efhc2

DIOPT Version :10

• Sequence 1: NP_611459.1
• Gene: Efhc1.2 / 37284
• FlyBaseID: FBgn0034487
• Length: 765
• Species: Drosophila melanogaster
• Sequence 2: NP_083192.2
• Gene: Efhc2 / 74405
• MGIID: 1921655
• Length: 750
• Species: Mus musculus
• Alignment Length: 785
• Identity: 259/785 - (32%)
• Similarity: 416/785 - (52%)
• Gaps: 69/785 - (8%)

  Fly     7 MPMLPGAQF-YDRGKRRHPRQQTLMHYQGIQMLSDRREPELVEPNGIVAD--------PKCPPVP 62
            :|.|||..| .:.||.|..:.|.......::||....:|      |:..|        ||
Mouse     3 LPFLPGNSFNRNIGKERFHKSQHWGFCNNVRMLVSENKP------GVGGDLLYGQKIKPK----- 56

  Fly    63 AQLNSLWAPKATTKLPPWLAYDKQVLCFNAYFKENLTEIYHAPYQVRKVKIFFYLEDGTMQVTEP 127
               :|::.....|..|.|:|:|||||.|:||.::.:::.....:::|..||:|||||.|:||.||
Mouse    57 ---HSVFPKGDGTDAPSWVAFDKQVLSFDAYLEDEISDKRQEIFRIRYYKIYFYLEDDTIQVNEP 118

  Fly   128 KVENSGIPQGCLVHRQRIPKAPPTDREFISIFDLNVDTDVQIFDRVYHISGCDVFTRQFLNRAGI 192
            :|.|||:|||..:.|||||..||.|.:|.:::|.|::..|..:.|.:.|..||.||:.||.:.||
Mouse   119 EVINSGLPQGTSIRRQRIPYPPPNDDQFYTVYDFNINISVVFYGRTFKIYDCDPFTKNFLKKIGI 183

  Fly   193 FVPEAQQEPCDPTTEIRKRSGLKQTGNTATSALPKK--HAFAQFLEFDRRVLKFQGYWND-RSEF 254
            .:....|.|.||..::|     ::|........|.:  ....:|:::|.:||:|...|:| .|.|
Mouse   184 KLNPPGQCPLDPYMKMR-----RETLEFVDPFRPYQSFDTLKRFIQYDGKVLRFFCLWDDSTSLF 243

  Fly   255 GDVRKLEVCYYLADDTIDIKEKFPRNSGREGPTTFLKRGKLPKEF-SGLPLPGQQTAMTLLNVLG 318
            ||.|:..:.|:|.|.|::|:|..|.||||:..::||:||||||.. .|:..|||.|...:|||.|
Mouse   244 GDRREFVLHYFLCDGTVEIREVLPSNSGRDAMSSFLRRGKLPKYGPPGIYQPGQITDRAVLNVYG 308

  Fly   319 --NSMRDVRYVADPLNTGQKEVQHYTDQDLQIGAVLNVFGRSVVLTSCDQFTQSYYREKYGIQEF 381
              :..|...|:.|....|:.|...||||||.|||.:||:||.|:|..||:||::|||.|||:..|
Mouse   309 GLSEWRADGYLLDKYQLGKVEQDFYTDQDLSIGATINVWGRKVLLCDCDEFTKTYYRTKYGVDNF 373

  Fly   382 SP---QPIPERSDIRPYTQGGMGSRRLPPYNGWGSHEDSEGNCITVEPKPPQADFKKLFKYDGC- 442
            :|   :| |....|         .|:.|||.|:||.|||..:|:.::|.|.:.:|||..:.|..
Mouse   374 TPISCKP-PHLPKI---------ERKYPPYTGFGSEEDSFRSCVGLKPTPHRKNFKKFMELDSFG 428

  Fly   443 ----ILRFGAKLISAIRDNGERDFVISYFLADDTLQIYETSRRNSGFLGGEFLKRARVPLPGQDM 503
                |||:..|||:....:.:|.|||:::|:|||:.::|....|||..||.||||:||..|||::
Mouse   429 NISNILRYFGKLITHKCADVDRIFVIAFYLSDDTISVFEPIENNSGNAGGMFLKRSRVKKPGQEV 493

  Fly   504 YSSSRPEYYRANDFYIGRTMTLKDHIFHIVSADEFTLMYMEQHPSEFPVADIQKIMQKIREAVRP 568
            :.|...||.:|.:.|||.|:.:..::|.:::|||:||.|||.:..:||.::.:..:||:::  ..
Mouse   494 FKSEFSEYIKAEELYIGATVNINGYLFILLNADEYTLNYMENNTDKFPYSNFELAIQKLKQ--EK 556

  Fly   569 DYKQFVLRCKPDGDLGDYTAVSFETLRSTLLSYLSKDCLLNHEIVTVCRFFSAEQAMPPSCDRNR 633
            ...:.:.:.....|......|.:.|.|..|:| ::...|::.|::|:.|.:...:.|.|  |...
Mouse   557 SKSREITQVFAAADYNHTKVVPYNTFRDILMS-ITMGKLIDQELITIARHYRVPEIMDP--DLAY 618

  Fly   634 VRAAAQLELKRALWNGMDQLNDHLSHINPACKPYISEGQVRSTLRGCRLPFSLELVEDILMVLQR 698
            :.|.|..:.|:.::...|....:..:.:...|..:....:|...:..|||...:.: |.|:....
Mouse   619 LIARAHEKFKKNIFENFDMFIYNCVYEDREKKGVLPTKDIRRMCKSSRLPLDDDFL-DCLLSRFE 682

  Fly   699 NGQNEIEVRDFLAFFNMRNDQVPDIAPLNIAFELC--------PKLPFLHKGRLVDFTWFLDYLG 755
            :..::|....|.:..|.|.:..||:.......|.|        ..:|..:. |.:||  .:|..|
Mouse   683 DKDHQINYEIFFSVLNWRMNPTPDLQAPPYLKEKCEDVWVGMPSPIPVKYV-RYLDF--LIDVYG 744

  Fly   756 IEEEL 760
            :|:.:
Mouse   745 LEDNM 749

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Efhc1.2	NP_611459.1	DM10	84..191	CDD:128921	48/106 (45%)
		DM10_dom	231..368	CDD:461948	62/140 (44%)
		DM10	440..547	CDD:128921	47/111 (42%)
Efhc2	NP_083192.2	DM10	75..182	CDD:128921	48/106 (45%)
		DM10_dom	219..360	CDD:461948	62/140 (44%)
		DM10_dom	418..529	CDD:461948	45/110 (41%)