DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Efhc1.2 and Efhc1

DIOPT Version :9

Sequence 1:	NP_611459.1	Gene:	Efhc1.2 / 37284	FlyBaseID:	FBgn0034487	Length:	765	Species:	Drosophila melanogaster
Sequence 2:	NP_082250.1	Gene:	Efhc1 / 71877	MGIID:	1919127	Length:	648	Species:	Mus musculus

Alignment Length:	746	Identity:	223/746 - (29%)
Similarity:	349/746 - (46%)	Gaps:	143/746 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 GMPMLPGAQFYDRGKRRHPRQQTLMHYQGIQMLSDRREPELVEPNGIVAD--------------- 55
            |:|.|||:.|.|..|....|.|||.:..|..::   |.|.:    ||..|
Mouse     8 GLPFLPGSSFTDSTKTAFHRSQTLNYRNGYAVV---RRPTM----GIGGDRLHYNQLSQAELDEL 65

  Fly    56 -PKCP-----PVPAQLNSLWAPKATTKLPPWLAYDKQVLCFNAYFKENLTEIYHAPYQVRKVKIF 114
             .|.|     |:..      ||.|.. :|..:|:||:||.|:|||:|::.......|::|.|.|:
Mouse    66 ANKAPILTYGPLKQ------APLAEF-VPAHVAFDKKVLKFSAYFQEDVPISMEEHYRIRHVNIY 123

  Fly   115 FYLEDGTMQVTEPKVENSGIPQGCLVHRQRIPKAPPTDREFISIFDLNVDTDVQIFDRVYHISGC 179
            :||||.:|.|.||.|||||||||.|:.|||..|....|.....  |||...::.::.:.:.|..|
Mouse   124 YYLEDDSMSVIEPVVENSGIPQGKLIKRQRFTKNDMGDHYHWK--DLNRGINLTVYGKTFRIVDC 186

  Fly   180 DVFTRQFLNRAGIFVPEAQQEPCDPTTEIRKRSGLKQTGNTATSALPKKHAFAQFLEFDRRVLKF 244
            |.||:.||...||.:..:::.|.||.|::||....|....:....|      .|||.||::||:|
Mouse   187 DRFTQDFLESQGIELNPSEKIPLDPYTQLRKEPVRKYVTPSDFDQL------KQFLTFDKQVLRF 245

  Fly   245 QGYWNDR-SEFGDVRKLEVCYYLADDTIDIKEKFPRNSGREGPTTFLKRGKLPKEFSGLPLPGQQ 308
            ...|:|. |.||:.|...:.|||.|||::|:|...||:||:.....:.|.::||
Mouse   246 YAIWDDTDSLFGECRHYIIHYYLMDDTVEIREVHERNNGRDPFPLLMNRQRMPK----------- 299

  Fly   309 TAMTLLNVLGNSMRDVRYVADPLNTGQKEVQHYTDQDLQIGAVLNVFGRSVVLTSCDQFTQSYYR 373
               .|:....|..:.|..::|     |:.::.||.:|..:|..|.:.||:..:..||.||:.:|:
Mouse   300 ---VLVENAKNFPKCVLEISD-----QEVLEWYTAKDFIVGKPLTILGRTFFIYDCDPFTRQFYK 356

  Fly   374 EKYGIQEFSPQPIPERSDIRPYTQGGMGSRRLPPYNGWGSHEDSEGNCITVEPKPPQADFKKLFK 438
            :|:|:.:..|..:.:: :..|..|      .||||||:|..|||..||..:.||.|:.|..|:..
Mouse   357 DKFGMPDLPPVDVTKK-EPPPVKQ------ELPPYNGYGLIEDSAQNCFALIPKAPRKDVVKMLM 414

  Fly   439 YDGCILRFGAKLISAIRDNGERDFVISYFLADDTLQIYETSRRNSGFLGGEFLKRARVPLPGQDM 503
            .|..:||:.|.|.|.|.::.:|.||.|||||.|.:.|:|...||||.:||:||.|.:|.   :..
Mouse   415 NDNKVLRYLAALESPIPEDKDRRFVFSYFLATDMISIFEPPVRNSGIIGGKFLGRTKVV---KSF 476

  Fly   504 YSSSRPEYYRANDFYIGRTMTLKDHIFHIVSADEFTLMYMEQHPSEFPVADIQKIMQKIREAVRP 568
            .....|.||..:||:||..:.:..|.|.|:..||:.|.|||.:.|::....:..|..:|::...|
Mouse   477 SPVDNPIYYSPSDFFIGAVIEVFGHRFVILDTDEYVLKYMESNASQYSPEALASIQNRIQKPELP 541

  Fly   569 DYKQFVLRCKPDGDLGDYTAVSFETLRSTLLSYLSKDCLLNHEIVTVCRFFSAEQAMPPSCDRNR 633
                               |...|:.::|                        .:.|....:.::
Mouse   542 -------------------APELESKQAT------------------------GEPMVQGTEESK 563

  Fly   634 VRAAAQLELKRALWNGMDQLNDHLSHINPACKPYISE----------GQV-RST-LRGC---RLP 683
            |:....|         :||::.||.:  .:||..:.|          |.| |.| .:.|   .:|
Mouse   564 VQDLDAL---------IDQIHMHLKY--NSCKENLRETFQMYDKDESGYVDRETFFKICETLNVP 617

  Fly   684 FSLELVEDILMVLQRNGQNEIEVRDFLAFFN 714
            ....|:::::. |..:|:..|...:|:..|:
Mouse   618 VDDSLIKELIR-LCTHGEGRINYYNFVRAFS 647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Efhc1.2	NP_611459.1	DM10	84..191	CDD:128921	46/106 (43%)
		DUF1126	112..144	CDD:284078	20/31 (65%)
		DM10	238..376	CDD:128921	42/138 (30%)
		DUF1126	262..294	CDD:284078	13/31 (42%)
		DM10	440..547	CDD:128921	44/106 (42%)
		DUF1126	463..495	CDD:284078	18/31 (58%)
Efhc1	NP_082250.1	Required for its localization in the mitotic spindle and interaction with alpha-tubulin. /evidence=ECO:0000250\|UniProtKB:Q5JVL4	1..45		15/39 (38%)
		DM10	93..198	CDD:128921	46/106 (43%)
		DUF1126	122..153	CDD:284078	20/30 (67%)
		DM10	239..359	CDD:128921	42/138 (30%)
		DUF1126	263..296	CDD:284078	13/32 (41%)
		DM10	416..520	CDD:128921	44/106 (42%)
		DUF1126	439..471	CDD:284078	18/31 (58%)
		EFh	587..647	CDD:238008	12/60 (20%)
		EF-hand_7	587..646	CDD:290234	12/59 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	84	1.000	Domainoid score	I8231
eggNOG	1	0.900	-	-		E1_KOG0043
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56477
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002682
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101134
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4447
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.750