DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Efhc1.2 and efhc1

DIOPT Version :9

Sequence 1:	NP_611459.1	Gene:	Efhc1.2 / 37284	FlyBaseID:	FBgn0034487	Length:	765	Species:	Drosophila melanogaster
Sequence 2:	NP_001008106.1	Gene:	efhc1 / 493468	XenbaseID:	XB-GENE-1011237	Length:	544	Species:	Xenopus tropicalis

Alignment Length:	567	Identity:	194/567 - (34%)
Similarity:	289/567 - (50%)	Gaps:	68/567 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 GMPMLPGAQFYDRGKRRHPRQQTLMHYQG-----IQMLSDRREP------------ELVEPNGIV 53
            |:|.|||..:.|..|....|.|||.:..|     :..:...|||            ||......:
Frog     8 GLPFLPGNTYRDPTKSAFHRSQTLTYKNGYSRPILPTVGIGREPITANQLSQAELDELANKRPTL 72

  Fly    54 ADPKCPPVPAQLNSLWAPKATTKLPPWLAYDKQVLCFNAYFKENLTEIYHAPYQVRKVKIFFYLE 118
            ...:..|.|          .:..:|.::|:||:||.|..||:|.:.......|:||:|.:::|||
Frog    73 TYGRAKPAP----------PSDFIPSYVAFDKKVLRFEGYFQETVPLSPEEHYRVRRVTLYYYLE 127

  Fly   119 DGTMQVTEPKVENSGIPQGCLVHRQRIPKAPPTDREFISIFDLNVDTDVQIFDRVYHISGCDVFT 183
            |.|:.|.||.:||||||||..:.|||.||....|.....  ||||..:|.::.|.:.:..||.||
Frog   128 DDTISVIEPPMENSGIPQGTFIKRQRHPKNANGDPYHWK--DLNVGINVTLYGRTFRLISCDSFT 190

  Fly   184 RQFLNRAGIFVPEAQQEPCDPTTEIRKRSGLKQTGNTATSALPKK-HAFAQFLEFDRRVLKFQGY 247
            ::||...||.:...:..|.||.||:|:|.       ..|...|.. ....|:|..||:||:|...
Frog   191 QEFLESEGIELNPPEGIPTDPFTELRRRP-------NRTFVTPSDFDKLKQYLTMDRKVLRFFAV 248

  Fly   248 WND-RSEFGDVRKLEVCYYLADDTIDIKEKFPRNSGREGPTTFLKRGKLPKEFSGLPLPGQQTAM 311
            |:| .|.||:...:.:.|||:|||::|:|...||.||:.....:||..|||
Frog   249 WDDTESMFGEKHPVLIHYYLSDDTVEIREVHERNDGRDPFPVLMKRQHLPK-------------- 299

  Fly   312 TLLNVLGNSMRDVRYVADPLNTGQKEVQH-YTDQDLQIGAVLNVFGRSVVLTSCDQFTQSYYREK 375
                 :.|..:|. :....|....:||:. ::..|.::|..:::.||...:..||.:|:.:||:|
Frog   300 -----VVNDTKDT-FPMCVLEISDQEVKEWFSPGDFKVGKHISILGRKFFIYDCDAYTRDFYRDK 358

  Fly   376 YGIQEFSPQPI-PERSDIRPYTQGGMGSRRLPPYNGWGSHEDSEGNCITVEPKPPQADFKKLFKY 439
            .||.:..|..: .||.|     :.....:.:|||||:|..|||..||:::.||||:.|..|:.:.
Frog   359 MGIGDLQPVEVNKERED-----EEEKVIQEIPPYNGFGLLEDSLQNCLSLVPKPPKKDVLKMLEN 418

  Fly   440 DGCILRFGAKLISAIRDNGERDFVISYFLADDTLQIYETSRRNSGFLGGEFLKRARVPLPGQDMY 504
            |..:||:...|.|...::..|.||:|||||:|.|.|:|...||||.:||:||:::||.:||..:
Frog   419 DHNVLRYVVILDSPNPEDKVRRFVLSYFLANDMLSIFERQVRNSGIIGGKFLEKSRVLVPGSTV- 482

  Fly   505 SSSRPEYYRANDFYIGRTMTLKDHIFHIVSADEFTLMYMEQHPSEFP 551
              ..|.||...||.||..:.:.:|.|.|..|||:.|.||:.|..|||
Frog   483 --DNPIYYGPKDFTIGAAIEVFNHRFIITDADEYVLNYMKAHSKEFP 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Efhc1.2	NP_611459.1	DM10	84..191	CDD:128921	46/106 (43%)
		DUF1126	112..144	CDD:284078	17/31 (55%)
		DM10	238..376	CDD:128921	41/139 (29%)
		DUF1126	262..294	CDD:284078	14/31 (45%)
		DM10	440..547	CDD:128921	45/106 (42%)
		DUF1126	463..495	CDD:284078	18/31 (58%)
efhc1	NP_001008106.1	DUF1126	86..190	CDD:368977	44/105 (42%)
		DUF1126	232..351	CDD:368977	40/138 (29%)
		DUF1126	414..515	CDD:368977	43/103 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	60	1.000	Domainoid score	I10395
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D126718at33208
OrthoFinder	1	1.000	-	-		FOG0002682
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010