DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Efhc1.2 and efhc1

DIOPT Version :9

Sequence 1:	NP_611459.1	Gene:	Efhc1.2 / 37284	FlyBaseID:	FBgn0034487	Length:	765	Species:	Drosophila melanogaster
Sequence 2:	NP_957261.1	Gene:	efhc1 / 393942	ZFINID:	ZDB-GENE-040426-1300	Length:	554	Species:	Danio rerio

Alignment Length:	588	Identity:	201/588 - (34%)
Similarity:	297/588 - (50%)	Gaps:	82/588 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 GMPMLPGAQFYDRGKRRHPRQQTLMHYQGIQMLSDRREPELVEPNGIVADP--KCPPVPAQLNSL 68
            |:|.|||..|.|..|....|.|||....|   .:..|.|.:    ||..||  ......::.|.|
Zfish     8 GLPFLPGNTFRDLTKSAFHRAQTLDFKNG---YAQPRRPVV----GIGQDPLLSVNISHSERNQL 65

  Fly    69 WA--PKAT----------TKLPPWLAYDKQVLCFNAYFKENLTEIYHAPYQVRKVKIFFYLEDGT 121
            ..  |..|          ..:|...||||:||.|..||::.:...:...:::|.|..:::|||.:
Zfish    66 ITDIPNLTYGTDRSHLPLEFIPAHAAYDKKVLRFYGYFRQEVLHSWDEHFRIRPVVFYYHLEDDS 130

  Fly   122 MQVTEPKVENSGIPQGCLVHRQRIPKAPPTDREFISIF---DLNVDTDVQIFDRVYHISGCDVFT 183
            :.||||.|||||||||.|:.|||:.|.|..|     ::   ||||..|:.:|..||.|:.||.||
Zfish   131 ICVTEPPVENSGIPQGKLIKRQRLSKNPRGD-----LYHWKDLNVGMDINLFGEVYRITHCDPFT 190

  Fly   184 RQFLNRAGIFVPEAQQEPCDPTTEIRKRSGLKQTGNTATSALP--KKHAFAQFLEFDRRVLKFQG 246
            :.|:...||.:.|.:..|.||.|       .::..|..|...|  ..|...:||..||:||:|..
Zfish   191 QDFMESQGIVLNEFESIPSDPYT-------ARRAHNQQTHITPYDHNHQLERFLALDRQVLRFFA 248

  Fly   247 YWNDR-SEFGDVRKLEVCYYLADDTIDIKEKFPRNSGREGPTTFLKRGKLPKEFSGL--PLPGQQ 308
            .|:|. |.:|:.|.:.:.|||.||:::|.|....||||:.....|:|.|:||.....  |.|.
Zfish   249 LWDDSDSLYGEKRPVTLHYYLVDDSVEICEHHEANSGRDPFPVLLRRQKIPKHIKPTCEPFPS-- 311

  Fly   309 TAMTLLNVLGNSMRDVRYVADPLNTGQKEVQHYTDQDLQIGAVLNVFGRSVVLTSCDQFTQSYYR 373
                  .||..|..||:             :::..||.::|..:|:.||..:|..||.||..||:
Zfish   312 ------CVLEVSPHDVK-------------EYFCPQDFRVGEEVNLMGRRFLLYDCDDFTHKYYQ 357

  Fly   374 EKYGIQEFSPQPIPERS--DIRPYTQGGMGSRRLPPYNGWGSHEDSEGNCITVEPKPPQADFKKL 436
            ..:......|..:..|:  ||:         |.:|||||:||.|||..||:::.|:||:.:..||
Zfish   358 HHHPDIPIKPFTVDTRTQQDIK---------RVIPPYNGFGSLEDSLQNCLSLIPQPPKKNVIKL 413

  Fly   437 FKYDGCILRFGAKLISA-IRDNGERDFVISYFLADDTLQIYETSRRNSGFLGGEFLKRARVPLPG 500
            .:.|..:||:.|:|.|. ..|.|.| |::|:.||||.:.|:|.|.||||.:||:||::.|:|.||
Zfish   414 LENDHKVLRYAARLDSQNPLDEGRR-FILSFHLADDMISIFEKSTRNSGIIGGKFLEKTRIPKPG 477

  Fly   501 QDMYSSSRPEYYRANDFYIGRTMTLKDHIFHIVSADEFTLMYMEQHPSEFPVADIQKIMQKIREA 565
            .   ::.:||||:..|..:|.|:.:..|.|.:..||.|.|.::|....:.|    :..:..:|.|
Zfish   478 S---TAEKPEYYQPADLCVGATVEVFGHRFVVTDADRFVLSFLESQSHQTP----EHTLSSLRHA 535

  Fly   566 VRP 568
            ..|
Zfish   536 TDP 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Efhc1.2	NP_611459.1	DM10	84..191	CDD:128921	46/109 (42%)
		DUF1126	112..144	CDD:284078	18/31 (58%)
		DM10	238..376	CDD:128921	46/140 (33%)
		DUF1126	262..294	CDD:284078	13/31 (42%)
		DM10	440..547	CDD:128921	44/107 (41%)
		DUF1126	463..495	CDD:284078	16/31 (52%)
efhc1	NP_957261.1	DM10	93..198	CDD:128921	46/109 (42%)
		DUF1126	121..153	CDD:284078	18/31 (58%)
		DM10	240..356	CDD:128921	44/136 (32%)
		DUF1126	264..297	CDD:284078	13/32 (41%)
		DM10	417..521	CDD:128921	44/107 (41%)
		DUF1126	440..472	CDD:284078	16/31 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0043
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56477
OrthoDB	1	1.010	-	-		D126718at33208
OrthoFinder	1	1.000	-	-		FOG0002682
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101134
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4447
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.760