Protein Alignment Efhc1.2 and Efhc2

DIOPT Version :10

• Sequence 1: NP_611459.1
• Gene: Efhc1.2 / 37284
• FlyBaseID: FBgn0034487
• Length: 765
• Species: Drosophila melanogaster
• Sequence 2: NP_001100422.1
• Gene: Efhc2 / 302507
• RGDID: 1563388
• Length: 750
• Species: Rattus norvegicus
• Alignment Length: 784
• Identity: 261/784 - (33%)
• Similarity: 418/784 - (53%)
• Gaps: 67/784 - (8%)

  Fly     7 MPMLPGAQF-YDRGKRRHPRQQTLMHYQGIQMLSDRREPELVEPNGIVADPKCPPVPAQ----LN 66
            :|:|||..| .:.||.:..|.|.......::||....:|      ||..|    .:|.|    .:
  Rat     3 LPLLPGNSFNRNIGKEKFHRSQHWGFCNNVRMLVSEDKP------GIGGD----LLPGQKIKPKH 57

  Fly    67 SLWAPKATTKLPPWLAYDKQVLCFNAYFKENLTEIYHAPYQVRKVKIFFYLEDGTMQVTEPKVEN 131
            |::.....|..|.|:|:|||||.|:||.::.:.:.....:::|..||:|||||.|:||.||:|.|
  Rat    58 SVFPKGDGTDAPSWVAFDKQVLSFDAYLEDEVPDKRQENFRIRYYKIYFYLEDDTIQVNEPEVIN 122

  Fly   132 SGIPQGCLVHRQRIPKAPPTDREFISIFDLNVDTDVQIFDRVYHISGCDVFTRQFLNRAGIFVPE 196
            ||:|||..:.|.|||..||.|.:|.:::|.|::..|..:.|.:.|..||.||:.||.:.||.:..
  Rat   123 SGLPQGTSIRRHRIPFPPPYDDQFYTVYDFNINISVVFYGRTFKIYDCDPFTKNFLRKIGIKLNP 187

  Fly   197 AQQEPCDPTTEIRKRSGLKQTGNTATSALPKK--HAFAQFLEFDRRVLKFQGYWND-RSEFGDVR 258
            ..|.|.||..::|     ::|........|.:  ....:||::|.:||:|...|:| .|.|||.|
  Rat   188 PGQRPFDPYMKMR-----RETLEFVDPFRPYQSFDTLKRFLQYDGKVLRFFCLWDDSASLFGDRR 247

  Fly   259 KLEVCYYLADDTIDIKEKFPRNSGREGPTTFLKRGKLPKEFS--GLPLPGQQTAMTLLNVLG--N 319
            :..:.|:|.||||:|:|..|.||||:..::||:|.|||| |.  |:..|||.|...:|||.|  :
  Rat   248 EFVLHYFLCDDTIEIREILPSNSGRDAMSSFLRRSKLPK-FGPPGIYQPGQITDRAVLNVYGGLS 311

  Fly   320 SMRDVRYVADPLNTGQKEVQHYTDQDLQIGAVLNVFGRSVVLTSCDQFTQSYYREKYGIQEFS-- 382
            ..|...|:.|....|:.|...||||||.|||.:||:||.|:|..||:||::||:.|||:..|:
  Rat   312 EWRADGYLLDKYQLGKIEQDFYTDQDLSIGATINVWGRKVLLCDCDEFTKTYYKTKYGVDNFTPI 376

  Fly   383 ---PQPIPERSDIRPYTQGGMGSRRLPPYNGWGSHEDSEGNCITVEPKPPQADFKKLFKYDGC-- 442
               |.|:|:.            .|:.|||.|:||.|||..:|::::|.|.:.:|:|..:.|..
  Rat   377 SCKPPPLPKI------------KRKYPPYTGFGSEEDSFRSCVSLKPTPHRKNFRKFMELDSFGN 429

  Fly   443 ---ILRFGAKLISAIRDNGERDFVISYFLADDTLQIYETSRRNSGFLGGEFLKRARVPLPGQDMY 504
               |||:.||||:....:.:|.|||:::|:|||:.::|...||||..||.||||:||..|||:::
  Rat   430 VSNILRYFAKLITHKCADVDRMFVIAFYLSDDTISVFEPIERNSGNAGGMFLKRSRVKKPGQEVF 494

  Fly   505 SSSRPEYYRANDFYIGRTMTLKDHIFHIVSADEFTLMYMEQHPSEFPVADIQKIMQKIREAVRPD 569
            .|...||.:|.:.|||.|:.:..::|.:::|||:||.|||.:...||.::.:..:||::.  ...
  Rat   495 KSEFSEYVKAEELYIGATVNINGYLFLLLNADEYTLNYMESNTDRFPYSNFELAIQKLKH--EKS 557

  Fly   570 YKQFVLRCKPDGDLGDYTAVSFETLRSTLLSYLSKDCLLNHEIVTVCRFFSAEQAMPPSCDRNRV 634
            ..:.:.:.....|......|.:...|..|:| ::...|::.|::|:.|.:...:.|.|  |...:
  Rat   558 KSREITQVFAAADYNHTKVVPYNAFRDILMS-ITMGNLIDQELITIARHYRVPEVMDP--DLAYL 619

  Fly   635 RAAAQLELKRALWNGMDQLNDHLSHINPACKPYISEGQVRSTLRGCRLPFSLELVEDILMVLQRN 699
            .|.|..:.|:.::...|....:..:.:...|..:....::...:..|||.|.:.::.:|...:..
  Rat   620 IAQAHEKFKKNMFENFDMFIYNCVYEDRERKGVLPTTDIKRMCKSSRLPLSDDFLDCLLSRFEDK 684

  Fly   700 GQNEIEVRDFLAFFNMRNDQVPDIAPLNIAFELC--------PKLPFLHKGRLVDFTWFLDYLGI 756
            .| :|....|.:..|.|.:..||:.......|.|        ..:|..:. |.:||  .:|..|:
  Rat   685 DQ-QINYEIFFSLLNWRMNPTPDLQAPPYLKEKCEDVWVGMPSPIPVRYV-RYLDF--LMDVYGL 745

  Fly   757 EEEL 760
            ||.:
  Rat   746 EENM 749

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Efhc1.2	NP_611459.1	DM10	84..191	CDD:128921	47/106 (44%)
		DM10_dom	231..368	CDD:461948	65/141 (46%)
		DM10	440..547	CDD:128921	49/111 (44%)
Efhc2	NP_001100422.1	DM10	75..182	CDD:128921	47/106 (44%)
		DM10_dom	219..360	CDD:461948	65/141 (46%)
		DM10_dom	418..529	CDD:461948	46/110 (42%)