Protein Alignment Efhc1.2 and Efhc1

DIOPT Version :10

• Sequence 1: NP_611459.1
• Gene: Efhc1.2 / 37284
• FlyBaseID: FBgn0034487
• Length: 765
• Species: Drosophila melanogaster
• Sequence 2: NP_001116419.2
• Gene: Efhc1 / 301295
• RGDID: 1587365
• Length: 648
• Species: Rattus norvegicus
• Alignment Length: 744
• Identity: 233/744 - (31%)
• Similarity: 352/744 - (47%)
• Gaps: 139/744 - (18%)

  Fly     6 GMPMLPGAQFYDRGKRRHPRQQTLMHYQGIQMLSDRREPELVEPNGIVAD--PKCPPVPAQLNSL 68
            |:|:|||:.|.|..|....|.|||.:..|...:   |.|.:    ||..|  |.....||:|:.|
  Rat     8 GLPLLPGSSFTDSTKTAFHRSQTLGYRNGYAFV---RRPTM----GIGGDRLPYNQLSPAELDEL 65

  Fly    69 WAPKA-------------TTKLPPWLAYDKQVLCFNAYFKENLTEIYHAPYQVRKVKIFFYLEDG 120
             |.||             ...:|..:|:||:||.|:|||:|::.......|::|:|.|::||||.
  Rat    66 -ANKAPILTYGPLKQAAPAEFVPAHVAFDKKVLKFSAYFQEDVPISMEEHYRIRRVNIYYYLEDD 129

  Fly   121 TMQVTEPKVENSGIPQGCLVHRQRIPKAPPTDREFISIFDLNVDTDVQIFDRVYHISGCDVFTRQ 185
            :|.|.||.|||||||||.||.|||:.|....|.....  |||...::.|:.:.:.|..||.||:.
  Rat   130 SMSVIEPVVENSGIPQGKLVKRQRLAKNDVGDHYHWK--DLNRGINLTIYGKTFRIVDCDRFTQD 192

  Fly   186 FLNRAGIFVPEAQQEPCDPTTEIRKRSGLKQTGNTATSALPKKHAFAQFLEFDRRVLKFQGYWND 250
            ||...||.:..:::.|.||.||:||....|....:....|      .|||.||::||:|...|:|
  Rat   193 FLESQGIELNPSEKMPLDPYTELRKEPVRKYVTPSDFDQL------KQFLTFDKQVLRFYAIWDD 251

  Fly   251 R-SEFGDVRKLEVCYYLADDTIDIKEKFPRNSGREGPTTFLKRGKLPKEFSGLPLPGQQTAMTLL 314
            . |.||:.|...:.|||.|||::|:|...||:||:.....:.|.::||              .|:
  Rat   252 TDSLFGECRHYIIHYYLMDDTVEIREVHERNNGRDPFPLLMNRQRMPK--------------VLV 302

  Fly   315 NVLGNSMRDVRYVADPLNTGQKEVQHYTDQDLQIGAVLNVFGRSVVLTSCDQFTQSYYREKYGIQ 379
            :...|..:.|..::|     |:.::.||.:|..:|..|.:.||:..:..||.||:.:|::|:|:.
  Rat   303 DNGKNFPQCVLEISD-----QEVLEWYTAKDFIVGKPLTILGRTFFIYDCDPFTRQFYKDKFGMS 362

  Fly   380 EFSPQPIPERSDIRPYTQGGMGSRRLPPYNGWGSHEDSEGNCITVEPKPPQADFKKLFKYDGCIL 444
            :. |:....:.:..|..|      .||||||:|..|||..||..:.||.|:.|..|:...|..:|
  Rat   363 DL-PRVDVSKKEPPPVKQ------ELPPYNGYGLIEDSAQNCFALVPKAPRKDIVKMLMNDNKVL 420

  Fly   445 RFGAKLISAIRDNGERDFVISYFLADDTLQIYETSRRNSGFLGGEFLKRARVPLPGQDMYSSSRP 509
            |:.|.|.|.|.::.:|.||.|||||.|.:.|:|...||||.:||:||.|.:|.   :.......|
  Rat   421 RYLAALESPIPEDKDRRFVFSYFLATDMISIFEPPVRNSGIIGGKFLGRTKVV---KSFSPVDNP 482

  Fly   510 EYYRANDFYIGRTMTLKDHIFHIVSADEFTLMYMEQHPSEFPVADIQKIMQKIREAVRPDYKQFV 574
            .||..:||:||..:.:..|.|.|:..||:.|.|||.:.|::....:..|..:||:...|..:
  Rat   483 IYYGPSDFFIGAVIEVFGHRFVILDTDEYVLKYMESNASQYSPEALASIQNRIRKQDSPAPE--- 544

  Fly   575 LRCKPDGDLGDYTAVSFETLRSTLLSYLSKDCLLNHEIVTVCRFFSAEQAMPPSCDRNRVRAAAQ 639
            |.||                                            ||      ....:|.|.
  Rat   545 LECK--------------------------------------------QA------TEETKALAT 559

  Fly   640 LELKRALWNGMDQLND----HLSHINPACKPYISE----------GQV--RSTLRGC---RLPFS 685
            .|||.   .|:|:|.:    ||..|  :||..:.|          |.|  .:..:.|   .:|..
  Rat   560 EELKA---QGLDKLIEKIQMHLKDI--SCKDNLRERFQVYDKEESGYVDKETFFKVCETLNVPVD 619

  Fly   686 LELVEDILMVLQRNGQNEIEVRDFLAFFN 714
            ..|:::::. |..:|:..|...:|:..|:
  Rat   620 DSLIKELIR-LCTHGEGRINYYNFVRAFS 647

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Efhc1.2	NP_611459.1	DM10	84..191	CDD:128921	48/106 (45%)
		DM10_dom	231..368	CDD:461948	43/137 (31%)
		DM10	440..547	CDD:128921	44/106 (42%)
Efhc1	NP_001116419.2	DM10	93..198	CDD:128921	48/106 (45%)
		DM10_dom	232..351	CDD:461948	44/143 (31%)
		DM10_dom	411..512	CDD:461948	41/103 (40%)
		EFh	587..647	CDD:238008	10/60 (17%)