DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Efhc1.2 and efhc-1

DIOPT Version :9

Sequence 1:	NP_611459.1	Gene:	Efhc1.2 / 37284	FlyBaseID:	FBgn0034487	Length:	765	Species:	Drosophila melanogaster
Sequence 2:	NP_509738.2	Gene:	efhc-1 / 190059	WormBaseID:	WBGene00013028	Length:	447	Species:	Caenorhabditis elegans

Alignment Length:	544	Identity:	135/544 - (24%)
Similarity:	218/544 - (40%)	Gaps:	133/544 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 PRQQTLMHYQGIQMLSDRREPELVEPNGIVADPKC-PPVPAQLNSLWAPKATT-----KLPPWL- 81
            |.:..|.|: |......||..:|...||     :| .||...:::.  ||..:     ...|.|
Worm    14 PTEDILEHF-GSDPTPVRRRQQLKYKNG-----ECFVPVETIVDNY--PKQRSFHHYCNAGPLLH 70

  Fly    82 ---AYDKQVLCFNAYFKEN-LTEIYHAPYQVRKVKIFFYLEDGTMQVTEPKVENSGIPQGCLVHR 142
               |.:..||.|:||.:|: |.|..|   ::|..||.::|.|.|:.|.||.|:|:|...|.:..|
Worm    71 EAEAANSAVLSFDAYAEEDGLDEEIH---RIRIFKINYHLNDDTITVNEPFVDNTGYLHGRIFRR 132

  Fly   143 QRIPKAPPTDREFISIFDLNVDTDVQIFDRVYHISGCDVFTRQFLNRAGIFVPEAQQEPCDPTTE 207
            |::|......:.::...||||.||:.:|..:|.|:.||.|||.||...|..|.|.::.|.||.
Worm   133 QKVPAHNRIGKPYVHWSDLNVGTDINLFQTIYRITSCDTFTRSFLEEHGTKVNEDEELPEDPW-- 195

  Fly   208 IRKRSGLKQTGNTATSALPKKHAFAQFLEFDRR--VLKFQGYWNDR-SEFGDVRK---LEVCYYL 266
            :.:|.|..:|    ...||.:.      ||..|  :|.::..|.|. ::|...|.   .::..|.
Worm   196 LVRRRGAPRT----APKLPDQR------EFINRPPMLVYRCCWLDHMNDFHGCRMKRIFKMYVYC 250

  Fly   267 ADDTIDIKEKFPRNSGREGPTTFLKRGKLPKEFSGLPLPGQQTAMTLLNVLGNSMRDVRYVADPL 331
            :|.|:.:.|:.....|:    .||||       ..||.|.|...:         .||.|:
Worm   251 SDHTVALIEETKEFEGQ----LFLKR-------IALPFPVQPDMV---------KRDYRW----- 290

  Fly   332 NTGQKEVQHYTDQDLQIGAVLNVFGRSVVLTSC-DQFTQSYYREKYGIQEFSPQPIPERSDIRPY 395
                        .|::.|..::||.|.:.:..| :..|:|:.|:::|..:|:
Worm   291 ------------WDIRPGVWVDVFCRPMFVFECANDETKSFTRQQFGETDFA------------- 330

  Fly   396 TQGGMGSRRLPPYNGWGSHEDSEGNCITVEPKPPQADFKKLFKYDGCILRFGAKLISAIRDNGER 460
                          .:.|....||        ||...|..    ...||:|...::.|.......
Worm   331 --------------NYSSQILEEG--------PPTTQFFN----SPSILKFRCTMVDAPSVLYGL 369

  Fly   461 DFVISYFLADDTLQIYETSRRNSGFLGGEFLKRARVPLPGQDMYSSSRPEYYRANDFYIGRTMTL 525
            .|::.|.:....:.|.|..|: :...|..|||         |:.:|:    :..|.|..||.:..
Worm   370 HFLLYYDVNRRIVNINEEGRK-TWTDGRVFLK---------DVDAST----FSENQFAPGRILQF 420

  Fly   526 KDHIFHIVSADEFTLMYM--EQHP 547
            ....|::|.:...|..|:  :|.|
Worm   421 FKWRFNLVQSSGETGKYLRWKQTP 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Efhc1.2	NP_611459.1	DM10	84..191	CDD:128921	41/107 (38%)
		DUF1126	112..144	CDD:284078	13/31 (42%)
		DM10	238..376	CDD:128921	31/144 (22%)
		DUF1126	262..294	CDD:284078	9/31 (29%)
		DM10	440..547	CDD:128921	24/108 (22%)
		DUF1126	463..495	CDD:284078	8/31 (26%)
efhc-1	NP_509738.2	DM10	76..181	CDD:128921	41/107 (38%)
		DUF1126	102..134	CDD:284078	13/31 (42%)
		DM10	222..326	CDD:128921	30/140 (21%)
		PLPDE_III	<309..>370	CDD:294187	16/99 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	71	1.000	Domainoid score	I6151
eggNOG	1	0.900	-	-		E1_KOG0043
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56477
OrthoDB	1	1.010	-	-		D126718at33208
OrthoFinder	1	1.000	-	-		FOG0002682
OrthoInspector	1	1.000	-	-		otm14728
orthoMCL	1	0.900	-	-		OOG6_101134
Panther	1	1.100	-	-	LDO	PTHR12086
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4447
SonicParanoid	1	1.000	-	-		X4557
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.860