DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Efhc1.2 and EFHC1

DIOPT Version :9

Sequence 1:NP_611459.1 Gene:Efhc1.2 / 37284 FlyBaseID:FBgn0034487 Length:765 Species:Drosophila melanogaster
Sequence 2:NP_060570.2 Gene:EFHC1 / 114327 HGNCID:16406 Length:640 Species:Homo sapiens


Alignment Length:743 Identity:225/743 - (30%)
Similarity:348/743 - (46%) Gaps:145/743 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 GMPMLPGAQFYDRGKRRHPRQQTLMHYQGIQMLSDRREPELVEPNGIVAD--------------- 55
            |:|.|||..|.|..|....|.|||.:..|..::   |.|.:    ||..|               
Human     8 GLPFLPGTSFKDSTKTAFHRSQTLSYRNGYAIV---RRPTV----GIGGDRLQFNQLSQAELDEL 65

  Fly    56 -PKCPPV----PAQLNSLWAPKATTKLPPWLAYDKQVLCFNAYFKENLTEIYHAPYQVRKVKIFF 115
             .|.|.:    |.|     ||.|.. :|..:|:||:||.|:|||:|::.......|::|:|.|::
Human    66 ASKAPVLTYGQPKQ-----APPADF-IPAHVAFDKKVLKFDAYFQEDVPMSTEEQYRIRQVNIYY 124

  Fly   116 YLEDGTMQVTEPKVENSGIPQGCLVHRQRIPKAPPTDR-EFISIFDLNVDTDVQIFDRVYHISGC 179
            ||||.:|.|.||.||||||.||.|:.|||:.|   .|| :.....|||...::.|:.:.:.:..|
Human   125 YLEDDSMSVIEPVVENSGILQGKLIKRQRLAK---NDRGDHYHWKDLNRGINITIYGKTFRVVDC 186

  Fly   180 DVFTRQFLNRAGIFVPEAQQEPCDPTTEIRKRSGLKQTGNTATSALPKKHAFAQFLEFDRRVLKF 244
            |.||:.||...||.:...::...||.||:||:...|....:....|      .|||.||::||:|
Human   187 DQFTQVFLESQGIELNPPEKMALDPYTELRKQPLRKYVTPSDFDQL------KQFLTFDKQVLRF 245

  Fly   245 QGYWNDR-SEFGDVRKLEVCYYLADDTIDIKEKFPRNSGREGPTTFLKRGKLPKEFSGLPLPGQQ 308
            ...|:|. |.:|:.|...:.|||.|||::|:|...||.||:.....:.|.::||           
Human   246 YAIWDDTDSMYGECRTYIIHYYLMDDTVEIREVHERNDGRDPFPLLMNRQRVPK----------- 299

  Fly   309 TAMTLLNVLGNSMRDVRYVADPLNTGQKEVQHYTDQDLQIGAVLNVFGRSVVLTSCDQFTQSYYR 373
               .|:....|..:.|..::|     |:.::.||.:|..:|..|.:.||:..:..||.||:.||:
Human   300 ---VLVENAKNFPQCVLEISD-----QEVLEWYTAKDFIVGKSLTILGRTFFIYDCDPFTRRYYK 356

  Fly   374 EKYGIQEF--------SPQPIPERSDIRPYTQGGMGSRRLPPYNGWGSHEDSEGNCITVEPKPPQ 430
            ||:||.:.        .|.|:               .:.||||||:|..|||..||..:.||.|:
Human   357 EKFGITDLPRIDVSKREPPPV---------------KQELPPYNGFGLVEDSAQNCFALIPKAPK 406

  Fly   431 ADFKKLFKYDGCILRFGAKLISAIRDNGERDFVISYFLADDTLQIYETSRRNSGFLGGEFLKRAR 495
            .|..|:...|..:||:.|.|.|.|.::.:|.||.|||||.|.:.|:|...||||.:||::|.|.:
Human   407 KDVIKMLVNDNKVLRYLAVLESPIPEDKDRRFVFSYFLATDMISIFEPPVRNSGIIGGKYLGRTK 471

  Fly   496 VPLPGQDMYSS-SRPEYYRANDFYIGRTMTLKDHIFHIVSADEFTLMYMEQHPSEF---PVADIQ 556
            |..|    ||: ..|.||..:||:||..:.:..|.|.|:..||:.|.|||.:.:::   .:|.||
Human   472 VVKP----YSTVDNPVYYGPSDFFIGAVIEVFGHRFIILDTDEYVLKYMESNAAQYSPEALASIQ 532

  Fly   557 KIMQKIREAVRPDYKQFVLRCKPDGDLGDYTAVSFETLRSTLLSYLSKDCLLNHEIVTVCRFFSA 621
            ..::| |||..|:.:.  .:.:.|..:.:..|: .:|::..|..:..||                
Human   533 NHVRK-REAPAPEAES--KQTEKDPGVQELEAL-IDTIQKQLKDHSCKD---------------- 577

  Fly   622 EQAMPPSCDRNRVRAAAQLELKRALWNGMDQLNDHLSHINPACKPYISEGQVRSTLRGCRLPFSL 686
                       .:|.|.|:..|.|                   ..|:.............:|...
Human   578 -----------NIREAFQIYDKEA-------------------SGYVDRDMFFKICESLNVPVDD 612

  Fly   687 ELVEDILMVLQRNGQNEIEVRDFLAFFN 714
            .||::::.:.. :|:.:|...:|:..|:
Human   613 SLVKELIRMCS-HGEGKINYYNFVRAFS 639

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Efhc1.2NP_611459.1 DM10 84..191 CDD:128921 46/107 (43%)
DUF1126 112..144 CDD:284078 19/31 (61%)
DM10 238..376 CDD:128921 43/138 (31%)
DUF1126 262..294 CDD:284078 13/31 (42%)
DM10 440..547 CDD:128921 46/107 (43%)
DUF1126 463..495 CDD:284078 17/31 (55%)
EFHC1NP_060570.2 Required for its localization in the mitotic spindle and interaction with alpha-tubulin. /evidence=ECO:0000269|PubMed:19734894 1..45 15/39 (38%)
DM10 93..198 CDD:128921 46/107 (43%)
DUF1126 122..153 CDD:284078 19/30 (63%)
DM10 239..359 CDD:128921 43/138 (31%)
DUF1126 263..296 CDD:284078 13/32 (41%)
DM10 416..520 CDD:128921 46/107 (43%)
DUF1126 439..471 CDD:284078 17/31 (55%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 535..554 5/21 (24%)
EFh 579..639 CDD:238008 12/79 (15%)
EF-hand_7 579..638 CDD:290234 12/78 (15%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 82 1.000 Domainoid score I8413
eggNOG 1 0.900 - - E1_KOG0043
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG56477
OrthoDB 1 1.010 - - D126718at33208
OrthoFinder 1 1.000 - - FOG0002682
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_101134
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4447
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
98.760

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