Protein Alignment Efhc1.2 and EFHC1

DIOPT Version :10

• Sequence 1: NP_611459.1
• Gene: Efhc1.2 / 37284
• FlyBaseID: FBgn0034487
• Length: 765
• Species: Drosophila melanogaster
• Sequence 2: NP_060570.2
• Gene: EFHC1 / 114327
• HGNCID: 16406
• Length: 640
• Species: Homo sapiens
• Alignment Length: 743
• Identity: 225/743 - (30%)
• Similarity: 348/743 - (46%)
• Gaps: 145/743 - (19%)

  Fly     6 GMPMLPGAQFYDRGKRRHPRQQTLMHYQGIQMLSDRREPELVEPNGIVAD--------------- 55
            |:|.|||..|.|..|....|.|||.:..|..::   |.|.:    ||..|
Human     8 GLPFLPGTSFKDSTKTAFHRSQTLSYRNGYAIV---RRPTV----GIGGDRLQFNQLSQAELDEL 65

  Fly    56 -PKCPPV----PAQLNSLWAPKATTKLPPWLAYDKQVLCFNAYFKENLTEIYHAPYQVRKVKIFF 115
             .|.|.:    |.|     ||.|.. :|..:|:||:||.|:|||:|::.......|::|:|.|::
Human    66 ASKAPVLTYGQPKQ-----APPADF-IPAHVAFDKKVLKFDAYFQEDVPMSTEEQYRIRQVNIYY 124

  Fly   116 YLEDGTMQVTEPKVENSGIPQGCLVHRQRIPKAPPTDR-EFISIFDLNVDTDVQIFDRVYHISGC 179
            ||||.:|.|.||.||||||.||.|:.|||:.|   .|| :.....|||...::.|:.:.:.:..|
Human   125 YLEDDSMSVIEPVVENSGILQGKLIKRQRLAK---NDRGDHYHWKDLNRGINITIYGKTFRVVDC 186

  Fly   180 DVFTRQFLNRAGIFVPEAQQEPCDPTTEIRKRSGLKQTGNTATSALPKKHAFAQFLEFDRRVLKF 244
            |.||:.||...||.:...::...||.||:||:...|....:....|      .|||.||::||:|
Human   187 DQFTQVFLESQGIELNPPEKMALDPYTELRKQPLRKYVTPSDFDQL------KQFLTFDKQVLRF 245

  Fly   245 QGYWNDR-SEFGDVRKLEVCYYLADDTIDIKEKFPRNSGREGPTTFLKRGKLPKEFSGLPLPGQQ 308
            ...|:|. |.:|:.|...:.|||.|||::|:|...||.||:.....:.|.::||
Human   246 YAIWDDTDSMYGECRTYIIHYYLMDDTVEIREVHERNDGRDPFPLLMNRQRVPK----------- 299

  Fly   309 TAMTLLNVLGNSMRDVRYVADPLNTGQKEVQHYTDQDLQIGAVLNVFGRSVVLTSCDQFTQSYYR 373
               .|:....|..:.|..::|     |:.::.||.:|..:|..|.:.||:..:..||.||:.||:
Human   300 ---VLVENAKNFPQCVLEISD-----QEVLEWYTAKDFIVGKSLTILGRTFFIYDCDPFTRRYYK 356

  Fly   374 EKYGIQEF--------SPQPIPERSDIRPYTQGGMGSRRLPPYNGWGSHEDSEGNCITVEPKPPQ 430
            ||:||.:.        .|.|:               .:.||||||:|..|||..||..:.||.|:
Human   357 EKFGITDLPRIDVSKREPPPV---------------KQELPPYNGFGLVEDSAQNCFALIPKAPK 406

  Fly   431 ADFKKLFKYDGCILRFGAKLISAIRDNGERDFVISYFLADDTLQIYETSRRNSGFLGGEFLKRAR 495
            .|..|:...|..:||:.|.|.|.|.::.:|.||.|||||.|.:.|:|...||||.:||::|.|.:
Human   407 KDVIKMLVNDNKVLRYLAVLESPIPEDKDRRFVFSYFLATDMISIFEPPVRNSGIIGGKYLGRTK 471

  Fly   496 VPLPGQDMYSS-SRPEYYRANDFYIGRTMTLKDHIFHIVSADEFTLMYMEQHPSEF---PVADIQ 556
            |..|    ||: ..|.||..:||:||..:.:..|.|.|:..||:.|.|||.:.:::   .:|.||
Human   472 VVKP----YSTVDNPVYYGPSDFFIGAVIEVFGHRFIILDTDEYVLKYMESNAAQYSPEALASIQ 532

  Fly   557 KIMQKIREAVRPDYKQFVLRCKPDGDLGDYTAVSFETLRSTLLSYLSKDCLLNHEIVTVCRFFSA 621
            ..::| |||..|:.:.  .:.:.|..:.:..|: .:|::..|..:..||
Human   533 NHVRK-REAPAPEAES--KQTEKDPGVQELEAL-IDTIQKQLKDHSCKD---------------- 577

  Fly   622 EQAMPPSCDRNRVRAAAQLELKRALWNGMDQLNDHLSHINPACKPYISEGQVRSTLRGCRLPFSL 686
                       .:|.|.|:..|.|                   ..|:.............:|...
Human   578 -----------NIREAFQIYDKEA-------------------SGYVDRDMFFKICESLNVPVDD 612

  Fly   687 ELVEDILMVLQRNGQNEIEVRDFLAFFN 714
            .||::::.:.. :|:.:|...:|:..|:
Human   613 SLVKELIRMCS-HGEGKINYYNFVRAFS 639

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Efhc1.2	NP_611459.1	DM10	84..191	CDD:128921	46/107 (43%)
		DM10_dom	231..368	CDD:461948	42/137 (31%)
		DM10	440..547	CDD:128921	46/107 (43%)
EFHC1	NP_060570.2	Required for its localization in the mitotic spindle and interaction with alpha-tubulin. /evidence=ECO:0000269|PubMed:19734894	1..45		15/39 (38%)
		DM10	93..198	CDD:128921	46/107 (43%)
		DM10_dom	232..351	CDD:461948	43/143 (30%)
		DM10_dom	409..512	CDD:461948	43/106 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	535..554		5/21 (24%)
		EFh	579..639	CDD:238008	12/79 (15%)