DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Efhc1.2 and efhc2

DIOPT Version :9

Sequence 1:	NP_611459.1	Gene:	Efhc1.2 / 37284	FlyBaseID:	FBgn0034487	Length:	765	Species:	Drosophila melanogaster
Sequence 2:	NP_001136133.1	Gene:	efhc2 / 100126059	XenbaseID:	XB-GENE-960325	Length:	741	Species:	Xenopus tropicalis

Alignment Length:	726	Identity:	263/726 - (36%)
Similarity:	391/726 - (53%)	Gaps:	69/726 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 MPMLPGAQF-YDRGKRRHPRQQTLMHYQGIQMLSDRREPEL---------------VEPNGIVAD 55
            :|.|||..| .:.||.:..:.|...:...|.|.....:|.:               |.|.|:.:|
Frog     3 LPFLPGNSFNRNLGKEKFHKSQHFGYSNDISMWLGEEKPGVGGAPLLGQNLKPKFSVFPKGVGSD 67

  Fly    56 PKCPPVPAQLNSLWAPKATTKLPPWLAYDKQVLCFNAYFKENLTEIYHAPYQVRKVKIFFYLEDG 120
                                 .|.|:|:|||||.|:|||:|.:.:.....|::|:.||:|||||.
Frog    68 ---------------------APSWVAFDKQVLSFDAYFEEEVHQRREETYRIRQCKIYFYLEDD 111

  Fly   121 TMQVTEPKVENSGIPQGCLVHRQRIPKAPPTDREFISIFDLNVDTDVQIFDRVYHISGCDVFTRQ 185
            |:||.||:::|||||||.::.|.|||...|.|.:|.::..||::.|:..:.::|.|..||.|||.
Frog   112 TIQVVEPEIKNSGIPQGTIIRRHRIPLPAPNDDQFYTVDHLNLNKDIVFYSKIYRIVNCDEFTRN 176

  Fly   186 FLNRAGIFVPEAQQEPCDPTTEIRKRSGLKQTGNTATSALPKKHAFAQFLEFDRRVLKFQGYWND 250
            ||.:.|:.:......|.|..:..||:....|    ......:.....||||.||.||:|..:|:|
Frog   177 FLRKLGVRINPPDSVPSDAYSSTRKKMEEMQ----PLRPYERIDTLKQFLEHDRHVLRFFCFWDD 237

  Fly   251 RSEFGDVRKLEVCYYLADDTIDIKEKFPRNSGREGPTTFLKRGKLPKEF-SGLPLPGQQTAMTLL 314
            .:.|||.|:|.:.|||||||::|.|..|.||||:....||.||||||.. ..:|.|||.||.|:|
Frog   238 TTLFGDSRELVLYYYLADDTVEILEIIPANSGRDTTPVFLHRGKLPKSSPQNVPQPGQVTARTVL 302

  Fly   315 NVLGNSMRDVRYVADPLNTGQKEVQHYTDQDLQIGAVLNVFGRSVVLTSCDQFTQSYYREKYGIQ 379
            ||.|......||:.|.|.||....:.|.|.||.|||.|||:||.|:|..||:||::||:.|:||:
Frog   303 NVFGPMGHGGRYILDNLKTGAVHEEFYKDSDLTIGAALNVWGRKVILCDCDEFTKNYYKTKFGIE 367

  Fly   380 EFSPQPIPERSDIRPYTQGGMGSRRLPPYNGWGSHEDSEGNCITVEPKPPQADFKKLFKYD---- 440
            :|:|.........||       .:..|||||:||..|:..:|:.:.|||||.||||..:.|
Frog   368 DFTPVQYKAPQPPRP-------KKEFPPYNGFGSEADTLCSCMALLPKPPQRDFKKFMEKDRNGL 425

  Fly   441 -GCILRFGAKLISAIRDNGERDFVISYFLADDTLQIYETSRRNSGFLGGEFLKRARVPLPGQDMY 504
             ..:|||.|:|.:....:.||.|::||||:|||:.::|...||||.:||:||:|:||..|||.::
Frog   426 ESNVLRFVARLDTDNPIDKERKFIVSYFLSDDTVTVFEPQERNSGMVGGKFLERSRVKKPGQQLF 490

  Fly   505 SSSRPEYYRANDFYIGRTMTLKDHIFHIVSADEFTLMYMEQHPSEFPVADIQKIMQKIR---EAV 566
            .|...||:|..|.::|..:.....:|.:|.|||:...|||::.:|||::||..|..|:|   |..
Frog   491 KSELSEYFRPEDLFVGARVNFNGFLFILVDADEYVFNYMERNANEFPMSDISVITSKLRRIGETK 555

  Fly   567 RPDYKQFVLRCKPDGDLGDYTAVSFETLRSTLLSYLSKDCLLNHEIVTVCRFFSAEQAMPPSCDR 631
            ..:.||......|.|.    :.:.:|..|:.|:...:.. |..|||:|..|::|...  .|..|.
Frog   556 SREIKQHFEANDPTGT----SHMPYEIFRNLLVDIYANQ-LTEHEIMTTGRYYSIRD--KPEIDL 613

  Fly   632 NRVRAAAQLELKRALWNGMDQLNDHLSHINPACKPYISEGQVRSTLRGCRLPFSLELVEDILMV- 695
            ..:.|.||.:||:..:....:|:|...:.:.....::|   .:.||..|: .|.:.|.:|.|.|
Frog   614 GSLTAIAQEQLKKKSFENFSKLSDVFVYNDQEKNGWLS---FQKTLTICK-AFKIPLADDFLRVL 674

  Fly   696 LQRNGQNEIEV 706
            |:::.:|..:|
Frog   675 LEKHTENGDQV 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Efhc1.2	NP_611459.1	DM10	84..191	CDD:128921	50/106 (47%)
		DUF1126	112..144	CDD:284078	20/31 (65%)
		DM10	238..376	CDD:128921	71/138 (51%)
		DUF1126	262..294	CDD:284078	17/31 (55%)
		DM10	440..547	CDD:128921	45/111 (41%)
		DUF1126	463..495	CDD:284078	17/31 (55%)
efhc2	NP_001136133.1	DM10	75..180	CDD:128921	50/104 (48%)
		DUF1126	103..135	CDD:284078	20/31 (65%)
		DM10	225..364	CDD:128921	71/138 (51%)
		DUF1126	248..281	CDD:284078	17/32 (53%)
		DM10	427..533	CDD:128921	44/105 (42%)
		DUF1126	449..481	CDD:284078	17/31 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	141	1.000	Domainoid score	I4677
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H11863
Inparanoid	1	1.050	450	1.000	Inparanoid score	I1576
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D126718at33208
OrthoFinder	1	1.000	-	-		FOG0002682
OrthoInspector	1	1.000	-	-		otm48437
Panther	1	1.100	-	-	LDO	PTHR12086
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4447
SonicParanoid	1	1.000	-	-		X4557
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.190