DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11099 and SHOC2

DIOPT Version :9

Sequence 1:	NP_001286627.1	Gene:	CG11099 / 37282	FlyBaseID:	FBgn0034485	Length:	378	Species:	Drosophila melanogaster
Sequence 2:	NP_001311265.1	Gene:	SHOC2 / 8036	HGNCID:	15454	Length:	582	Species:	Homo sapiens

Alignment Length:	334	Identity:	86/334 - (25%)
Similarity:	149/334 - (44%)	Gaps:	61/334 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 KDVPMDLFLYEDLEEVYLKENFISVIPKWLLNITTLKFIHLAGNNLSELPVDIYMLENLEFLDVS 78
            :::|..::..:.|..:||:.|.|:.:.|.:.|::.|..:.:..|.:.:||.:|..|.||..|||:
Human   182 REIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVA 246

  Fly    79 NNELKELPPTLGLLLNLQQLNVSGNQLTELPVELSGLRNLEHLNIGKNQFRRLPVQLSECVRLNE 143
            :|:|:.||..:|....:..|::..|:|.:||..:..|.:|..|.:..|:...:|..|::|..|.|
Human   247 HNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEE 311

  Fly   144 LNVSDNEALVHIPER-ISNLPMLQSLA-ADRCALVYLPAALSKF--MNHVRIFHNTAINYIPM-V 203
            ||:.:|. :..:||. :|:|..|.||. |..|..:|.....|:|  :..:.:.|| .||.||. :
Human   312 LNLENNN-ISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHN-RINKIPFGI 374

  Fly   204 YER----FYQNFYDNRQRNTP-------------VAVHR--------KGLFWVRELETSTRLL-- 241
            :.|    ...|..||:..:.|             :|.::        .||..:..|..|..||
Human   375 FSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKK 439

  Fly   242 LPVGTRTV----------FPVPSVENRVSLYDDCLHALQTLNRFTP---------------VYEN 281
            ||.|...:          ..:.|:.|.::...|....:.|.|:.|.               :.||
Human   440 LPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGEN 504

  Fly   282 VAMHRLLPE 290
            :..|  |||
Human   505 LLTH--LPE 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11099	NP_001286627.1	leucine-rich repeat	4..25	CDD:275380	1/10 (10%)
		LRR_8	26..82	CDD:290566	19/55 (35%)
		leucine-rich repeat	26..48	CDD:275380	7/21 (33%)
		LRR	<43..>194	CDD:227223	46/154 (30%)
		LRR_4	47..87	CDD:289563	14/39 (36%)
		leucine-rich repeat	49..71	CDD:275380	6/21 (29%)
		leucine-rich repeat	72..95	CDD:275380	9/22 (41%)
		leucine-rich repeat	96..117	CDD:275380	6/20 (30%)
		leucine-rich repeat	118..140	CDD:275380	6/21 (29%)
		leucine-rich repeat	141..164	CDD:275380	9/23 (39%)
SHOC2	NP_001311265.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..88
		LRR 1	101..122
		leucine-rich repeat	104..124	CDD:275380
		PLN00113	<115..>483	CDD:215061	79/302 (26%)
		LRR 2	124..145
		leucine-rich repeat	125..147	CDD:275380
		LRR 3	147..169
		leucine-rich repeat	148..170	CDD:275380
		LRR 4	170..191		1/8 (13%)
		leucine-rich repeat	171..193	CDD:275380	1/10 (10%)
		LRR 5	193..214		6/20 (30%)
		leucine-rich repeat	194..216	CDD:275380	7/21 (33%)
		LRR 6	216..237		5/20 (25%)
		leucine-rich repeat	217..239	CDD:275380	6/21 (29%)
		LRR 7	239..260		10/20 (50%)
		leucine-rich repeat	240..262	CDD:275380	9/21 (43%)
		LRR 8	262..283		5/20 (25%)
		leucine-rich repeat	263..285	CDD:275380	6/21 (29%)
		LRR 9	285..307		5/21 (24%)
		leucine-rich repeat	286..332	CDD:275380	15/46 (33%)
		LRR 10	308..329		7/21 (33%)
		LRR 11	332..353		6/20 (30%)
		leucine-rich repeat	333..380	CDD:275380	15/47 (32%)
		LRR 12	356..377		6/21 (29%)
		LRR 13	380..400		4/19 (21%)
		leucine-rich repeat	381..403	CDD:275380	4/21 (19%)
		LRR 14	403..424		1/20 (5%)
		leucine-rich repeat	404..426	CDD:275380	3/21 (14%)
		LRR 15	426..448		7/21 (33%)
		leucine-rich repeat	427..449	CDD:275380	7/21 (33%)
		LRR 16	449..470		2/20 (10%)
		leucine-rich repeat	450..472	CDD:275380	2/21 (10%)
		PLN03150	<453..527	CDD:178695	12/61 (20%)
		LRR 17	472..494		4/21 (19%)
		leucine-rich repeat	473..495	CDD:275380	3/21 (14%)
		LRR 18	495..516		6/19 (32%)
		leucine-rich repeat	496..519	CDD:275380	6/18 (33%)
		LRR 19	518..540
		LRR 20	542..563
		leucine-rich repeat	543..563	CDD:275380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910