DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11099 and Lrrc28

DIOPT Version :9

Sequence 1:	NP_001286627.1	Gene:	CG11099 / 37282	FlyBaseID:	FBgn0034485	Length:	378	Species:	Drosophila melanogaster
Sequence 2:	XP_036009285.1	Gene:	Lrrc28 / 67867	MGIID:	1915689	Length:	376	Species:	Mus musculus

Alignment Length:	372	Identity:	99/372 - (26%)
Similarity:	160/372 - (43%)	Gaps:	57/372 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LHWSYLNFKDVPMDLFLYE---DLEEVYLKENFISVIPKWLL----NITTLKFI------HLAGN 57
            |..:|.|....|::|...|   .||.:|:|.|.::.:|:.|.    |:..|..:      :|..|
Mouse    20 LFLNYRNLHHFPLELLKDEGLQHLERLYMKRNSLTTLPENLAQKLPNLVELLGLFSSLGWYLHSN 84

  Fly    58 NLSELPVDIYMLENLEFLDVSNNELKELPPTLGLLLNLQQLNVSGNQLTELPVELSGLRNLEHLN 122
            |:..:|..|..|..|:.||:|:|.|:.:.|.:|.|..|:.|.::.|||..||.|:..|:.|:.|:
Mouse    85 NIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGGLRALRHLRLANNQLQFLPPEVGDLKELQTLD 149

  Fly   123 IGKNQFRRLPVQLSECVRLNELNVSDNEALVHIPERISNLPMLQSLAADRCALVYLPAAL--SKF 185
            |..|:...||.:|..|:.|..|.| |...|..:|..:..||.|..|:.....|..||..|  |:.
Mouse   150 ISSNRLLALPERLHLCLSLQYLTV-DRNRLCCVPRHLCQLPSLNELSMAGNHLASLPIDLGRSRE 213

  Fly   186 MNHVRIFHNTAINYIPMVYERFYQNFYDNRQRNTPVAVHRKGLFWVRELETST---RLLLPVGTR 247
            :.:|.:.:|..:..:|   ...|...........|:.:..     ||.|..|:   .:.||...:
Mouse   214 LQYVYVDNNIQLKGLP---SYLYNKVIGCNGCGIPIQLSE-----VRLLTFSSGQLTVFLPAEVK 270

  Fly   248 T-------VFPVPSVENRVSLYDDCLHAL-QTLNRFTPVYENVAMHRLLPEPYISSHINNGPIAR 304
            |       |.|:..:..| ||| ...|.| :.||..:|    :::.|.|.|      :.:.|:..
Mouse   271 TIGTEKDHVLPLQELTMR-SLY-RTYHGLWKDLNFLSP----ISLPRSLLE------LLHCPLGH 323

  Fly   305 CTNSTCSRCLYTSYYFMVVKRRGSTSKQL--------FTCNFCTNRC 343
            |  ..||..::|..|..:...|.:....|        |....|:.:|
Mouse   324 C--HLCSEPMFTFVYPKIFPLRETPMAGLHQRRTSIGFVAYCCSTQC 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11099	NP_001286627.1	leucine-rich repeat	4..25	CDD:275380	6/21 (29%)
		LRR_8	26..82	CDD:290566	20/65 (31%)
		leucine-rich repeat	26..48	CDD:275380	8/25 (32%)
		LRR	<43..>194	CDD:227223	51/162 (31%)
		LRR_4	47..87	CDD:289563	13/45 (29%)
		leucine-rich repeat	49..71	CDD:275380	7/27 (26%)
		leucine-rich repeat	72..95	CDD:275380	9/22 (41%)
		leucine-rich repeat	96..117	CDD:275380	8/20 (40%)
		leucine-rich repeat	118..140	CDD:275380	8/21 (38%)
		leucine-rich repeat	141..164	CDD:275380	7/22 (32%)
Lrrc28	XP_036009285.1	PRK15370	<8..>232	CDD:185268	65/215 (30%)
		leucine-rich repeat	43..66	CDD:275380	7/22 (32%)
		leucine-rich repeat	67..98	CDD:275380	7/30 (23%)
		leucine-rich repeat	99..121	CDD:275380	9/21 (43%)
		leucine-rich repeat	122..144	CDD:275380	9/21 (43%)
		PRK15387	<132..>359	CDD:185285	62/249 (25%)
		leucine-rich repeat	145..167	CDD:275380	8/21 (38%)
		leucine-rich repeat	168..190	CDD:275380	7/22 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004967
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000