Protein Alignment CG11099 and LRRC18

DIOPT Version :10

• Sequence 1: NP_611457.1
• Gene: CG11099 / 37282
• FlyBaseID: FBgn0034485
• Length: 378
• Species: Drosophila melanogaster
• Sequence 2: NP_001006940.3
• Gene: LRRC18 / 474354
• HGNCID: 23199
• Length: 261
• Species: Homo sapiens
• Alignment Length: 219
• Identity: 67/219 - (30%)
• Similarity: 110/219 - (50%)
• Gaps: 19/219 - (8%)

  Fly    23 YEDLEEVYLKENFISVIPKWLLNITTLKFIHLAGNNLSELPVDIYMLENLEFLDVSNNELKELPP 87
            ::..:.:.|.:..|:..||.:|.::.:..:.|:.|.:.::|..|...:||.:||:.:|.:.:||.
Human    26 FDGKKRLDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPE 90

  Fly    88 TLGLLLNLQQLNVSGNQLTE--LPVELSGLRNLEHLNIGKNQFRRLPVQLSECVRLNELNVSDNE 150
            ::|.:.:|..||||.|:||.  |||||..|:|:..:|:|.|....:|..|.....|:|:.:.||
Human    91 SIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEVGLHDN- 154

  Fly   151 ALVHIPERISNLPMLQSLAADRCALVYLPAALSKFMNHVRIFHNTAINYIPMVYE--------RF 207
            .|.:||..||.||.|:.|...|.... .|.....|::.:|...|     :.:|.|        |.
Human   155 LLNNIPVSISKLPKLKKLNIKRNPFP-KPGESEIFIDSIRRLEN-----LYVVEEKDLCAACLRK 213

  Fly   208 YQNFYD--NRQRNTPVAVHRKGLF 229
            .||..|  ||.:|......||.:|
Human   214 CQNARDNLNRIKNMATTTPRKTIF 237

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11099	NP_611457.1	leucine-rich repeat	4..25	CDD:275380	0/1 (0%)
		LRR	<19..>179	CDD:443914	51/157 (32%)
		leucine-rich repeat	26..48	CDD:275380	5/21 (24%)
		leucine-rich repeat	49..71	CDD:275380	4/21 (19%)
		leucine-rich repeat	72..95	CDD:275380	7/22 (32%)
		leucine-rich repeat	96..117	CDD:275380	13/22 (59%)
		leucine-rich repeat	118..140	CDD:275380	5/21 (24%)
		leucine-rich repeat	141..164	CDD:275380	10/22 (45%)
LRRC18	NP_001006940.3	LRR 1	28..49		5/20 (25%)
		LRR	<30..>179	CDD:443914	51/149 (34%)
		leucine-rich repeat	30..51	CDD:275380	5/20 (25%)
		LRR 2	51..72		4/20 (20%)
		leucine-rich repeat	52..74	CDD:275380	4/21 (19%)
		LRR 3	74..95		8/20 (40%)
		leucine-rich repeat	75..97	CDD:275380	7/21 (33%)
		LRR 4	97..118		12/20 (60%)
		leucine-rich repeat	98..122	CDD:275380	14/23 (61%)
		LRR 5	122..144		6/21 (29%)
		leucine-rich repeat	123..145	CDD:275380	5/21 (24%)
		LRR 6	145..167		9/22 (41%)
		leucine-rich repeat	146..168	CDD:275380	10/22 (45%)
		LRR 7	168..189		4/21 (19%)