DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG11044 and FBXL6

DIOPT Version :9

Sequence 1:NP_611456.1 Gene:CG11044 / 37281 FlyBaseID:FBgn0034484 Length:511 Species:Drosophila melanogaster
Sequence 2:NP_036294.2 Gene:FBXL6 / 26233 HGNCID:13603 Length:539 Species:Homo sapiens


Alignment Length:582 Identity:113/582 - (19%)
Similarity:179/582 - (30%) Gaps:230/582 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 GLRRKSSA----------QLEVMQKAGWKIDGDEKACYIDVDEDEDQDTENMIESNWRYLPDLVL 59
            |||.:::|          ..|....|||   ||.                         :|..:|
Human    84 GLRSEAAAAPAPAPAPTPTPEEGPDAGW---GDR-------------------------IPLEIL 120

  Fly    60 EQIFTYLTPKERYY-----AGLVCRQWYRAFYLPTVWNNFLVDDRTLTKPKFNYYSGWQFCLDHM 119
            .|||..|...:...     |..|||:|..|...|.:|:..     ||:.|               
Human   121 VQIFGLLVAADGPMPFLGRAARVCRRWQEAASQPALWHTV-----TLSSP--------------- 165

  Fly   120 RTQFCLSRIGRYVRG-----------IEFRPWHSFNNIFQFMTMLTWNIDKGREVNPDTQFIGIG 173
                   .:||..:|           :|:...:.|:.: |.:|::.|.    .:|:|..:.:|..
Human   166 -------LVGRPAKGGVKAEKKLLASLEWLMPNRFSQL-QRLTLIHWK----SQVHPVLKLVGEC 218

  Fly   174 SRIRTLVYHFPCNMSQPNDPEGIKLFGTGGQLLRVLKELLLRLTDLHTLKLVDFVLERYEANHLL 238
            ....|.                :||.|..|.....|..|......||:|.|...::|.......|
Human   219 CPRLTF----------------LKLSGCHGVTADALVMLAKACCQLHSLDLQHSMVESTAVVSFL 267

  Fly   239 DE----------------------VVCSCCTKMRVLNL--------------VNVTTMHCPIMHV 267
            :|                      ::.|||.:::||.:              |......||.:.|
Human   268 EEAGSRMRKLWLTYSSQTTAILGALLGSCCPQLQVLEVSTGINRNSIPLQLPVEALQKGCPQLQV 332

  Fly   268 GLFLNLQVLTISPQN-----------------------IDDDVLSLL--ADTKLRHLHLLQNC-- 305
            ...|||..|...|..                       :.::||..|  ....||.|. |:.|  
Human   333 LRLLNLMWLPKPPGRGVAPGPGFPSLEELCLASSTCNFVSNEVLGRLLHGSPNLRLLD-LRGCAR 396

  Fly   306 YTPSHLTISACGVKAWRNVKKTNPRLRVHLRLENLTDGEVVLQPEAPVHSITYCAPQTRIRAELL 370
            .||:.|....|     |.::      ::||.|...:|...:.:..:|..:..:|.         .
Human   397 ITPAGLQDLPC-----RELE------QLHLGLYGTSDRLTLAKEGSPFLTQKWCH---------T 441

  Fly   371 VRMVD---------HYKSTLAVYGHELLPRFSSPKPFHSRIDSLMLLMCRQCFNVDTLIIREKVS 426
            :|.:|         ..:..||.:       .|:|...|..:.||.|...|             |:
Human   442 LRELDLSGQGFSEKDLEQALAAF-------LSTPGGSHPALCSLNLRGTR-------------VT 486

  Fly   427 TSTLLLIAKTAKNLQHLHVRRFAVILRCDWPRHPEWSNEFYAWLKRNSRSYEAVEREISQIL 488
            .||:..:......|.:|::..    .|| .||          .|||..|..|.|:..:.|:|
Human   487 PSTVSSVISGCPGLLYLNLES----CRC-LPR----------GLKRAYRGLEEVQWCLEQLL 533

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG11044NP_611456.1 F-box-like 51..94 CDD:289689 14/47 (30%)
FBXL6NP_036294.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..27
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 49..111 6/26 (23%)
F-box-like 113..163 CDD:289689 16/79 (20%)
LRR 1 177..203 4/26 (15%)
AMN1 185..398 CDD:187754 44/234 (19%)
leucine-rich repeat 196..221 CDD:275381 6/29 (21%)
LRR 2 204..229 7/44 (16%)
leucine-rich repeat 222..247 CDD:275381 7/40 (18%)
LRR 3 230..255 7/24 (29%)
leucine-rich repeat 248..299 CDD:275381 10/50 (20%)
LRR 4 281..307 5/25 (20%)
leucine-rich repeat 300..329 CDD:275381 4/28 (14%)
LRR 5 312..337 4/24 (17%)
leucine-rich repeat 330..357 CDD:275381 6/26 (23%)
LRR 6 341..365 2/23 (9%)
AMN1 <357..508 CDD:187754 35/195 (18%)
leucine-rich repeat 358..385 CDD:275381 3/26 (12%)
LRR 7 368..393 7/25 (28%)
leucine-rich repeat 386..409 CDD:275381 9/28 (32%)
LRR 8 394..419 9/35 (26%)
LRR 9 423..449 4/34 (12%)
leucine-rich repeat 442..474 CDD:275381 7/38 (18%)
LRR 10 453..481 7/34 (21%)
leucine-rich repeat 475..499 CDD:275381 7/36 (19%)
LRR 11 482..507 6/37 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1947
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.