DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11044 and FBXO33

DIOPT Version :9

Sequence 1:	NP_611456.1	Gene:	CG11044 / 37281	FlyBaseID:	FBgn0034484	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_976046.1	Gene:	FBXO33 / 254170	HGNCID:	19833	Length:	555	Species:	Homo sapiens

Alignment Length:	510	Identity:	94/510 - (18%)
Similarity:	187/510 - (36%)	Gaps:	116/510 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 LPDLVLEQIFTYLTPKERYYAGLVCRQWYRAFYLPTVWNNFLVDDRTLTKPKFNYYSGWQFCL-- 116
            ||..::..||::|...:|..|...|..|....:.|.:|            |:.      :.||
Human    71 LPSELIVHIFSFLPAPDRLRASASCSHWRECLFYPALW------------PQL------RICLRV 117

  Fly   117 ---DHMRTQFCLSRIGRYVR--GIEFRP--------------------------------W-HSF 143
               :..|.:|.:.:.|.:||  .:||..                                | ...
Human   118 SPAEQPRLEFLMRKCGWFVRELRVEFAAENYLSGGGPGDGGGADTGTGGEEVEALQLSARWLEVL 182

  Fly   144 NNIFQFMTMLTWNIDKGREVNPDTQFIGI------GSRIRTLVYHFPCNMSQPNDPEGIKLFGTG 202
            ....:.:..:..:|...|.:...:.|..|      ||...|.:        ...||:|.|:
Human   183 RTYLELVLCVLVSIRNNRNLQKFSLFGDISVLQQQGSLSNTYL--------SKVDPDGKKI---- 235

  Fly   203 GQLLRVLKELLLRLTDLHTLKLVDFVLERYEANHL--LDEVVCSCCTKMRVL--NLVNVTTMHCP 263
            .|:.::.:|:|.....|..|. ..|:||......|  |...|.:....:.:|  |:...:|:
Human   236 KQIQQLFEEILSNSRQLKWLS-CGFMLEIVTPTSLSSLSNAVANTMEHLSLLDNNIPGNSTL--- 296

  Fly   264 IMHVGL--FLNLQVLTISPQNIDDDVLSLLADTK---LRHLHLLQNCYTPSHLTI-SACGVKAWR 322
            |..|.|  |:||..|.:...:...::..:|.|:.   |:.|.||.:..:..|.:: :....:.|:
Human   297 ITAVELERFVNLHSLALDFCDFTAEMARVLTDSNHVPLQRLSLLVHNVSVMHKSLDNMPNDEHWK 361

  Fly   323 NVKKTNPRLRVHLRLENLTDGEV--VLQPEAP---VHSITYCAPQTRIRAELLVRMVDHYKSTLA 382
            .:.:.:...||::...::...::  :|:|..|   :|..:|....:....:|:.|..|.: .|..
Human   362 ALSRKSTSFRVYIMAFDIKSEDMLKILKPSIPLERIHFDSYITCVSGAIVDLISRQYDKF-LTHF 425

  Fly   383 VYGHELLPRFSSPKPFHSRIDSLMLLMCRQCFNVDTLIIR-EKVSTSTLLLIAK-TAKNLQHLHV 445
            :..::::.....|....:|.:..::|:..:|..:..|.|. ..|....|:.||: ...:|:.|.|
Human   426 ILMNDVIDTSGFPDLSDNRNEDPLVLLAWRCTKLSLLAIHGYTVWAHNLIAIARLRGSDLKVLEV 490

  Fly   446 RRFAVILRCDWPRHPEWSNEFYAWLKRNSRSYEAVEREISQI---LGYKWRLLSD 497
            ...::    |:.:.           :...:..:.|...|.|:   ||..|..:.|
Human   491 TEESI----DFDQG-----------ELADQDVDPVHNLIEQVSLGLGQPWHAVMD 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11044	NP_611456.1	F-box-like	51..94	CDD:289689	11/39 (28%)
FBXO33	NP_976046.1	F-box-like	69..116	CDD:289689	13/62 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	1	0.960